I want to stain some T cell subsets (Th17 and Th1), do you have antibodies for that? I need for flow cytometer in sheep or goat.

Name: IL-17/IL-17A Antibody (41809) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB317
Price: 519 USD

Question

Accepted Answer

Unfortunately, we have neither a CD4 antibody nor an IL-17 antibody that has been validated in sheep or goat, although if you would like to try one you would again be eligible for our Innovators Reward Program. Please contact us at innovators@novusbio.com with any questions regarding this program.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, PmSpecies Glossary
Applications	IHC, IP, B/N, Dual ISH-IHC, ELISA(Cap)
Clone	41809
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB317U

Alexa Fluor 405 FAB317V

Alexa Fluor 488 IC317G-100UG

Alexa Fluor 532 FAB317X

Alexa Fluor 594 FAB317T

Alexa Fluor 647 FAB317R

Alexa Fluor 700 FAB317N

Alexa Fluor 750 FAB317S

Allophycocyanin IC317A

Biotin FAB317B

CoraFluor 1 FAB317CL1

DyLight 350 FAB317D

DyLight 405 FAB317E

DyLight 488 FAB317K

DyLight 550 FAB317L

DyLight 594 FAB317M

DyLight 650 FAB317W

DyLight 680 FAB317Y

DyLight 755 FAB317Z

FITC FAB317F

HRP FAB317H

Janelia Fluor 525 FAB317JF525

Janelia Fluor 549 FAB317I

Janelia Fluor 646 FAB317J

Janelia Fluor 669 FAB317JF669

PerCP FAB317C

Phycoerythrin IC317P

mFluor Violet 450 SE FAB317MFV450

mFluor Violet 500 SE FAB317MFV500

mFluor Violet 610 SE FAB317MFV610

Catalog# & Formulation	Size	Price
Carrier Free IC317G-100UG

Carrier Free IC317P

Carrier Free IC317A

Carrier Free MAB317-SP

Carrier Free MAB317-500

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB317U
Alexa Fluor 405	FAB317V
Alexa Fluor 488	IC317G-100UG
Alexa Fluor 532	FAB317X
Alexa Fluor 594	FAB317T
Alexa Fluor 647	FAB317R
Alexa Fluor 700	FAB317N
Alexa Fluor 750	FAB317S
Allophycocyanin	IC317A
Biotin	FAB317B
CoraFluor 1	FAB317CL1
DyLight 350	FAB317D
DyLight 405	FAB317E
DyLight 488	FAB317K
DyLight 550	FAB317L
DyLight 594	FAB317M
DyLight 650	FAB317W
DyLight 680	FAB317Y
DyLight 755	FAB317Z
FITC	FAB317F
HRP	FAB317H
Janelia Fluor 525	FAB317JF525
Janelia Fluor 549	FAB317I
Janelia Fluor 646	FAB317J
Janelia Fluor 669	FAB317JF669
PerCP	FAB317C
Phycoerythrin	IC317P
mFluor Violet 450 SE	FAB317MFV450
mFluor Violet 500 SE	FAB317MFV500
mFluor Violet 610 SE	FAB317MFV610

IL-17/IL-17A Antibody (41809) [Unconjugated]

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Publications for IL-17/IL-17A Antibody (MAB317)(28)

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Immunogen	E. coli-derived recombinant human IL-17 Ile20-Ala155 Accession # Q16552
Specificity	Detects human and primate IL-17 in direct ELISAs. In direct ELISAs, approximately 12% cross-reactivity with recombinant canine IL-17 is observed and 25%-50% reactivity with recombinant human (rh) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant mouse IL-17, rhIL-17B, rhIL-17C, rhIL-17D, rhIL-17E, or rhIL-17F is observed.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	IL17A
Purity Statement	Protein A or G purified from ascites
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Publications using MAB317	Applications	Species
MJ Park, Y Park, JW Choi, JA Baek, HY Jeong, HS Na, YM Moon, ML Cho, SH Park Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skin Experimental & Molecular Medicine, 2022-09-29;54(9):1577-1585. 2022-09-29 [PMID: 36175484] (IHC, Human)	IHC	Human
L Gorchs, S Ahmed, C Mayer, A Knauf, C Fernández, M Svensson, R Heuchel, E Rangelova, P Bergman, H Kaipe The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity Sci Rep, 2020-10-15;10(1):17444. 2020-10-15 [PMID: 33060625] (ELISA Capture, Human)	ELISA Capture	Human
Nikki P. L. Toledo, Hongzhao Li, Robert W. Omange, Tamara G. Dacoba, Jose Crecente-Campo, Dane Schalk et al. Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens Frontiers in Immunology 8/25/2020 [PMID: 32983121]
Wen‑Bin Zheng, Lu‑Jiao Li, Di‑Chen Zhao, Ou Wang, Yan Jiang, Wei‑Bo Xia et al. A novel variant in AIRE causing a rare, non‑classical autoimmune polyendocrine syndrome type 1 Molecular Medicine Reports 6/12/2020 [PMID: 32627016]
J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (ELISA Capture, Human)	ELISA Capture	Human
Valentin Haug, Branislav Kollar, Sotirios Tasigiorgos, Yori Endo, Martin Kauke, Ali-Farid Safi et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours Transplantation 2020-09-01 [PMID: 32168040]
Y Liao, J Zhao, K Bulek, F Tang, X Chen, G Cai, S Jia, PL Fox, E Huang, TT Pizarro, MF Kalady, MW Jackson, S Bao, GC Sen, GR Stark, CJ Chang, X Li Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis Nat Commun, 2020-02-14;11(1):900. 2020-02-14 [PMID: 32060280] (IHC, Mouse)	IHC	Mouse
Y Liao, J Zhao, K Bulek, F Tang, X Chen, G Cai, S Jia, PL Fox, E Huang, TT Pizarro, MF Kalady, MW Jackson, S Bao, GC Sen, GR Stark, CJ Chang, X Li Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis Nat Commun, 2020;11(1):900. 2020 [PMID: 32060280] (IHC, Mouse)	IHC	Mouse
JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models Cells, 2019-09-15;8(9):. 2019-09-15 [PMID: 31540162] (ELISA Capture, Human)	ELISA Capture	Human
J Jhun, SH Lee, SK Lee, HY Kim, ES Jung, DG Kim, J Choi, SH Bae, SK Yoon, BH Chung, CW Yang, ML Cho, JY Choi Serial Monitoring of Immune Markers Being Represented Regulatory T Cell/T Helper 17 Cell Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation Front Immunol, 2018-03-01;9(0):352. 2018-03-01 [PMID: 29545795] (ELISA Capture, Human)	ELISA Capture	Human
R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3 Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972. 2017-08-09 [PMID: 28793286] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
E Brencicova, AL Jagger, HG Evans, M Georgouli, A Laios, S Attard Mon, G Mehra, J Spencer, AA Ahmed, S Raju-Kanki, LS Taams, SS Diebold Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma PLoS ONE, 2017-04-14;12(4):e0175712. 2017-04-14 [PMID: 28410380] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Dobrina N Hull Increase in circulating Th17 cells during anti-TNF therapy is associated with ultrasonographic improvement of synovitis in rheumatoid arthritis Arthritis Res. Ther, 2016-12-23;18(1):303. 2016-12-23 [PMID: 28010726] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Barbara Metzler, Patrick Gfeller, Elisabeth Guinet Restricting Glutamine or Glutamine-Dependent Purine and Pyrimidine Syntheses Promotes Human T Cells with High FOXP3 Expression and Regulatory Properties The Journal of Immunology 2016-05-01 [PMID: 27022197]
Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage. Eur J Immunol, 2015-12-14;46(2):440-5. 2015-12-14 [PMID: 26558442] (Neutralization, Human)	Neutralization	Human
Todd J, Simpson P, Estis J, Torres V, Wub A Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays. Cytokine, 2013-10-12;64(3):660-5. 2013-10-12 [PMID: 24128872] (ELISA Development, Human)	ELISA Development	Human
Yoshikazu Nakamura, Akira Ishiguro, Shin Miyakawa RNA plasticity and selectivity applicable to therapeutics and novel biosensor development Genes to Cells 2012-05-01 [PMID: 22487172]
Chang Y, Al-Alwan L, Risse PA, Roussel L, Rousseau S, Halayko AJ, Martin JG, Hamid Q, Eidelman DH TH17 cytokines induce human airway smooth muscle cell migration. J. Allergy Clin. Immunol., 2011-02-22;127(4):1046-53.e1-2. 2011-02-22 [PMID: 21345484] (Neutralization, Human)	Neutralization	Human
Robert Mabry, Katherine E. Lewis, Margaret Moore, Patricia A. McKernan, Thomas R. Bukowski, Kristen Bontadelli et al. Engineering of stable bispecific antibodies targeting IL-17A and IL-23 Protein Engineering, Design and Selection 2010-03-01 [PMID: 20022918]
Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients. Immunol. Lett., 2009-11-04;127(2):150-6. 2009-11-04 [PMID: 19895848] (ELISA Development, IHC-P, Human)	ELISA Development, IHC-P	Human
Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis MA, Miossec P Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes. J. Immunol., 2009-03-01;182(0):3112-20. 2009-03-01 [PMID: 19234208] (IHC-P, Human)	IHC-P	Human
Rahmoun M, Moles JP, Pedretti N, Mathieu M, Fremaux I, Raison-Peyron N, Lecron JC, Yssel H, Pene J Cytokine-induced CEACAM1 expression on keratinocytes is characteristic for psoriatic skin and contributes to a prolonged lifespan of neutrophils. J. Invest. Dermatol., 2008-10-09;129(3):671-81. 2008-10-09 [PMID: 18843289] (Neutralization, Human)	Neutralization	Human
Rickel EA, Siegel LA, Yoon BR, Rottman JB, Kugler DG, Swart DA, Anders PM, Tocker JE, Comeau MR, Budelsky AL Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol., 2008-09-15;181(6):4299-310. 2008-09-15 [PMID: 18768888] (Neutralization, Human)	Neutralization	Human
Zrioual S, Toh ML, Tournadre A, Zhou Y, Cazalis MA, Pachot A, Miossec V, Miossec P IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J. Immunol., 2008-01-01;180(1):655-63. 2008-01-01 [PMID: 18097068] (IHC-P, Human)	IHC-P	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (Luminex Development, Human)	Luminex Development	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA Development, Human)	ELISA Development	Human
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol., 2005-11-01;175(9):6177-89. 2005-11-01 [PMID: 16237115] (Neutralization, Human)	Neutralization	Human
Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J. Immunol., 2004-07-15;173(2):1463-76. 2004-07-15 [PMID: 15240743] (Flow Cytometry, Neutralization, Human)	Flow Cytometry, Neutralization	Human
Show All 28 Publications. Collapse Publications.

Gene Symbol	IL17A
Uniprot	Q16552()