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IL-12 R beta 2 Antibody (622509)

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Western blot shows lysates of human CD4+in vitrodifferentiated Th1 cells. PVDF Membrane was probed with 2 µg/mL of Mouse Anti-Human IL-12 R beta 2 Monoclonal Antibody (Catalog # MAB19591) followed by HRP-conjugated ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
622509
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price
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IL-12 R beta 2 Antibody (622509) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human IL-12 R beta 2
Lys24-Cys622
Accession # Q99665
Specificity
Detects human IL-12 R beta 2 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human IL‑12 R beta 1 or recombinant mouse IL-12 R beta 1 is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
IL12RB2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-12 R beta 2 Antibody (622509)

  • IL-12 R beta 2
  • IL-12 receptor beta 2
  • IL-12 receptor subunit beta-2
  • IL12R beta 2
  • IL-12R subunit beta-2
  • IL12RB2
  • IL-12Rb2
  • IL-12R-beta-2
  • interleukin 12 receptor, beta 2
  • interleukin-12 receptor beta-2 chain
  • interleukin-12 receptor subunit beta-2

Background

IL-12 R beta 2 is a type I cytokine receptor family protein that associates with IL 12 R beta 1 to form a functional high affinity receptor complex for IL-12. The extracellular region of IL 12 R beta 2 contains five fibronectin type 3 domains. The cytoplasmic region is alternatively spliced, giving rise to two isoforms. IL-12 R beta 2 is up‑regulated in Th1 cells during inflammatory responses. The extracellular regions of human and mouse IL‑12 R beta 2 share 69% amino acid sequence identity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IL12RB2
Uniprot