IL-23R Antibody

IL-23 is a heterodimeric cytokine that shares biological properties with proinflammatory cytokines. IL-23 is composed of the IL-12p40 soluble receptor subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. IL-23 mediates it cellular function by binding to IL-23R, which pairs with IL-12Rb1 to confer IL-23 responsiveness. However, human IL-12 does not bind to human IL-23R. IL-23 has been shown to possess biological activities on T cells that are similar as well distinct from those of IL-12.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Flow-CS, IF/IHC, WB.

Showing Publications 1 - 8 of 8.

Publications using NB600-1147	Applications	Species
Gupta S, Pungsrinont T, Zenata O et al. Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells Horm Cancer 2020-06-20 [PMID: 32562083]
Tan Q, Ma XY, Liu W et al. Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus Arch. Dermatol. Res. 2019-05-14 [PMID: 31089878] (IF/IHC, Human)	IF/IHC	Human
Xu X, Yang C, Chen J et al. Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway Biochem Biophys Res Commun 2018-03-23 [PMID: 29574157] (IF/IHC, Human)	IF/IHC	Human
Nakayama W, Jinnin M, Tomizawa Y et al. Dysregulated interleukin-23 signalling contributes to the increased collagen production in scleroderma fibroblasts via balancing microRNA expression. Rheumatology (Oxford) 2016-10-15 [PMID: 27744356] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Walker CR, Hautefort I, Dalton JE, et al. Intestinal Intraepithelial Lymphocyte-Enterocyte Crosstalk Regulates Production of Bactericidal Angiogenin 4 by Paneth Cells upon Microbial Challenge. PLoS One 2013-12-17 [PMID: 24358364] (Flow-CS, Mouse)	Flow-CS	Mouse
Wang S, Xu X, Xie A et al. Anti-interleukin-12/23p40 antibody attenuates chronic rejection of cardiac allografts partly via inhibition gamma delta T cells Clin Exp Immunol 2012-09-01 [PMID: 22861372] (IF/IHC, Mouse)	IF/IHC	Mouse
Li Z, Wu F, Brant SR, Kwon JH. IL-23 receptor regulation by Let-7f in human CD4+ memory T cells. J Immunol. 2011-06-01 [PMID: 21508257] (WB, Human) Details: IL-23 Receptor (IMG-5092A). WB: Human primary memory T cells transfected with control or Let-7f, Fig 6.	WB	Human
Kortylewski M, Xin H, Kujawski M et al. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell. 2009-02-03 [PMID: 19185846] (Flow-CS, Mouse) Details: IL-23R (IMG-5092A): Flow (cell surface), mouse spleen and lymph nodes including lymph nodes from tumor models, Fig 5A. Prior to staining, freshly isolated cells were preincubated with an FcgammaIII/IIR-specific antibody to block non-specific binding. The	Flow-CS	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Patricia Prieto	IF	Mouse	04/11/2018	View Summary Application Immunofluorescence Sample Tested Heart tissue Species Mouse Lot 02171694A-08 Comments Comments Previously blocked with BSA 6%+2% normal goat serum. Secondary antibody used: Goat anti-rabbit alexa fluor 546 (Molecular Probes) 1/500. It works pretty well althought there is some non-specific signal mainly associated to the tissue-autofluorescence.

Array NB600-1147

• IL-23R Antibodies
• IL-23R Lysate
• IL-23R Protein
• IL-23R ELISA
• IL-23R Proteins and Enzymes