Name: IL-10 Antibody (23738) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB217
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, B/N
Clone	23738
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Formulation	Size	Price
Carrier Free MAB217-SP

Carrier Free MAB217-500

Immunogen	E. coli-derived recombinant human IL‑10 Ser19-Asn178 Accession # P22301
Specificity	Detects human IL-10 in Western blots. In Western blots, this antibody shows approximately 5% cross-reactivity with recombinant mouse IL-10.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	IL10
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

IL-10 Antibody (23738) [Unconjugated]

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IL-10 Antibody (23738) [Unconjugated] Summary

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Publications for IL-10 Antibody (MAB217)(30)

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Bioinformatics

Publications using MAB217	Applications	Species
Giraud, J;Chalopin, D;Ramel, E;Boyer, T;Zouine, A;Derieppe, MA;Larmonier, N;Adotevi, O;Le Bail, B;Blanc, JF;Laurent, C;Chiche, L;Derive, M;Nikolski, M;Saleh, M; THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1 Cell reports 2024-02-12 [PMID: 38350444] (Neutralization, Human)	Neutralization	Human
A Dumigan, O Cappa, B Morris, J Sá Pessoa, R Calderon-G, G Mills, R Lancaster, D Simpson, A Kissenpfen, JA Bengoechea In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection Embo Molecular Medicine, 2022-11-07;0(0):e16888. 2022-11-07 [PMID: 36337046] (Neutralization, Human)	Neutralization	Human
S Shankar, J Stolp, SC Juvet, J Beckett, PS Macklin, F Issa, J Hester, KJ Wood Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis Nature Communications, 2022-06-03;13(1):3121. 2022-06-03 [PMID: 35660734] (Neutralization, Human)	Neutralization	Human
T Fukasawa, A Yoshizaki, S Ebata, A Yoshizaki-, Y Asano, A Enomoto, K Miyagawa, Y Kazoe, K Mawatari, T Kitamori, S Sato Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model Elife, 2021-12-02;10(0):. 2021-12-02 [PMID: 34854378] (Neutralization, Human)	Neutralization	Human
Arpita Saha, Hamdi Ben Halima, Abhishek Saini, Juan Gallardo-Gonzalez, Nadia Zine, Clara Viñas et al. Magnetic Nanoparticles Fishing for Biomarkers in Artificial Saliva Molecules 8/31/2020 [PMID: 32878151]
Amaro Nunes Duarte-Neto, Julio Croda, Carla Pagliari, Francisco Garcia Soriano, Antonio Carlos Nicodemo, Maria Irma Seixas Duarte Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock Frontiers in Immunology 2019-04-30 [PMID: 31114579]
K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study BMC Infect. Dis, 2017-03-24;17(1):228. 2017-03-24 [PMID: 28340570] (Neutralization, Human)	Neutralization	Human
BD Hock, SA MacPherson, JL McKenzie Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells PLoS ONE, 2017-03-03;12(3):e0172858. 2017-03-03 [PMID: 28257435] (Neutralization, Human)	Neutralization	Human
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages Sci Rep, 2016-08-25;6(0):31959. 2016-08-25 [PMID: 27558590] (Blocking, Human)	Blocking	Human
Lucio Roberto Castellano, Laurent Argiro, Helia Dessein, Alain Dessein, Marcos Vinícius da Silva, Dalmo Correia et al. Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis Journal of Immunology Research 2015-10-01 [PMID: 26495321]
Heine G, Drozdenko G, Grun J, Chang H, Radbruch A, Worm M Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol, 2014-03-11;44(6):1615-21. 2014-03-11 [PMID: 24643722] (Neutralization, Human)	Neutralization	Human
Herath S, Benlahrech A, Papagatsias T, Athanasopoulos T, Bouzeboudjen Z, Hervouet C, Klavinskis L, Meiser A, Kelleher P, Dickson G, Patterson S Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses. PLoS ONE, 2014-02-05;9(2):e88327. 2014-02-05 [PMID: 24505475] (ELISA Development (Capture), Human)	ELISA Development (Capture)	Human
Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L TNF-alpha blockade induces IL-10 expression in human CD4+ T cells. Nat Commun, 2014-01-01;5(0):3199. 2014-01-01 [PMID: 24492460] (Neutralization, Human)	Neutralization	Human
Jacqueline K Flynn, Gregory J Dore, Margaret Hellard, Barbara Yeung, William D Rawlinson, Peter A White et al. Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment Journal of Gastroenterology and Hepatology 2013-11-01 [PMID: 23663030]
A T R-Viso, M I S Duarte, C Pagliari, E R Fernandes, R A Brasil, G Benard et al. Tissue and serum immune response in chronic hepatitis C with mild histological lesions Memórias do Instituto Oswaldo Cruz 2010-02-01 [PMID: 20209325]
Aurelija Dubicke, Emma Fransson, Gabriele Centini, Eva Andersson, Birgitta Byström, Anders Malmström et al. Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening Journal of Reproductive Immunology 2010-03-01 [PMID: 20096464]
Gruber SG, Gloria Luciani M, Grundtner P, Zdanov A, Gasche C Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1. Eur. J. Immunol., 2008-12-01;38(12):3365-75. 2008-12-01 [PMID: 19016528] (Western Blot, Human)	Western Blot	Human
Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J. Virol., 2007-03-21;81(11):5882-92. 2007-03-21 [PMID: 17376924] (Neutralization, Human)	Neutralization	Human
Bayry J, Triebel F, Kaveri SV, Tough DF Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J. Immunol., 2007-04-01;178(7):4184-93. 2007-04-01 [PMID: 17371975] (Neutralization, Human)	Neutralization	Human
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (Luminex Development, Human)	Luminex Development	Human
Fischer J, West J, Agochukwu N, Suire C, Hale-Donze H Induction of host chemotactic response by Encephalitozoon spp. Infect. Immun., 2006-12-18;75(4):1619-25. 2006-12-18 [PMID: 17178789] (Neutralization, Human)	Neutralization	Human
Iliopoulou EG, Karamouzis MV, Missitzis I, Ardavanis A, Sotiriadou NN, Baxevanis CN, Rigatos G, Papamichail M, Perez SA Increased frequency of CD4+ cells expressing CD161 in cancer patients. Clin. Cancer Res., 2006-12-01;12(23):6901-9. 2006-12-01 [PMID: 17145807] (Neutralization, Human)	Neutralization	Human
Ebert EC, Mehta V Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 2006-08-17;241(1):7-13. 2006-08-17 [PMID: 16914126] (Neutralization, Human)	Neutralization	Human
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2004-09-16;105(2):750-8. 2004-09-16 [PMID: 15374887] (Neutralization, Human)	Neutralization	Human
Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254] (Affinity Chromatography, Human)	Affinity Chromatography	Human
Perrier P, Martinez FO, Locati M, Bianchi G, Nebuloni M, Vago G, Bazzoni F, Sozzani S, Allavena P, Mantovani A Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. J. Immunol., 2004-06-01;172(11):7031-42. 2004-06-01 [PMID: 15153525] (Neutralization, Human)	Neutralization	Human
Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology, 2004-06-01;112(2):274-89. 2004-06-01 [PMID: 15147571] (Flow Cytometry, Human)	Flow Cytometry	Human
Godfrey WR, Ge YG, Spoden DJ, Levine BL, June CH, Blazar BR, Porter SB In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood, 2004-03-18;104(2):453-61. 2004-03-18 [PMID: 15031211] (Flow Cytometry, Human)	Flow Cytometry	Human
Koenen HJ, Fasse E, Joosten I IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression. J. Immunol., 2003-12-15;171(12):6431-41. 2003-12-15 [PMID: 14662842] (Neutralization, Human)	Neutralization	Human
Corinti S, la Sala A, Pastore S Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol., 2001-04-01;166(7):4312-8. 2001-04-01 [PMID: 11254683] (Neutralization, Human)	Neutralization	Human
Show All 30 Publications. Collapse Publications.

Gene Symbol	IL10
Uniprot	P22301()