IGF-II R/IGF2R Antibody

CD222 is a 250kDa transmembrane protein with a short cytoplasmic tail containing an internalization signal. CD222 was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via CD222 either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of CD222 molecules (approximately 90-95%) are located intracellularly, only 5-10% is present on the cell membrane. The internalization rate seems to be enhanced by ligand induced dimerization of CD222 as well as by phosphorylation of its cytoplasmic serine. CD222 is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta [PROW].

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-84598	Applications	Species
Prabakaran T, Nielsen R, Satchell SC et al. Mannose 6-Phosphate Receptor and Sortilin Mediated Endocytosis of alpha-Galactosidase A in Kidney Endothelial Cells. PLoS One 2012-01-01 [PMID: 22768187]
Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Identification of beta-secretase (BACE1) substrates using quantitative proteomics. PLoS One 2009-12-29 [PMID: 20041192] (WB, Human)	WB	Human

Array NBP1-84598

• IGF-II R/IGF2R Antibodies
• IGF-II R/IGF2R Protein
• IGF-II R/IGF2R Proteins and Enzymes
• IGF-II R/IGF2R ELISA