Species: Hu, Mu, Rt, Bv, Pm
Applications: WB, ELISA, Flow, ICC/IF, IHC, IP, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: WB, Flow, IHC, B/N, CyTOF-ready, ICC/IF
Host: Goat Polyclonal
Species: Hu, Mu, Bv, Pl, Pm
Applications: WB, DB, ICC/IF, NULL
Host: Rabbit Polyclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: Binding Activity
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: AC
Description
CD222 is a 250kDa transmembrane protein with a short cytoplasmic tail containing an internalization signal. CD222 was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via CD222 either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of CD222 molecules (approximately 90-95%) are located intracellularly, only 5-10% is present on the cell membrane. The internalization rate seems to be enhanced by ligand induced dimerization of CD222 as well as by phosphorylation of its cytoplasmic serine. CD222 is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta [PROW].
Bioinformatics
| Entrez |
Mouse
Rat
Bovine
Human
|
| Uniprot |
Human
Bovine
Human
|
| Product By Gene ID |
3482 |
| Alternate Names |
- 300 kDa mannose 6-phosphate receptor
- cation-independent mannose-6 phosphate receptor
- cation-independent mannose-6-phosphate receptor
- CD222 antigen
- CD222
- CI Man-6-P receptor
- CIMPR
- CI-MPR
- IGF-II receptor
- insulin-like growth factor 2 receptorM6P/IGF2R
- Insulin-like growth factor II receptor
- M6P/IGF2 receptor
- M6PR
- M6P-R
- MPR 300
- MPR1
- MPRIM6PR
|
![Flow Cytometry IGF-II R/IGF2R Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IGF-II_R_AF2447_Flow_Cytometry_8177.jpg)
![Immunocytochemistry IGF-II R/IGF2R Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IGFII_R_AF2447_Immunocytochemistry__Immunofluorescence_24176.jpg)
![Immunocytochemistry IGF-II R/IGF2R Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IGFII_R_AF2447_Immunocytochemistry__Immunofluorescence_24177.jpg)
![Immunohistochemistry IGF-II R/IGF2R Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IGF-II_R_AF2447_Immunohistochemistry_6750.jpg)
![N/A IGF-II R/IGF2R [Biotin]](http://images.novusbio.com/fullsize2/DATA_IGFII_R_DY2447_ELISA_1831.jpg)
![Binding Activity IGF-II R/IGF2R [Unconjugated]](http://images.novusbio.com/fullsize2/2447-gr_recombinant-human-igf-ii-r-igf2r-protein-cf-binding-activity-932021133724.jpg)