Reactivity | HuSpecies Glossary |
Applications | WB, IHC, ICC/IF, KO |
Clonality | Polyclonal |
Host | Goat |
Conjugate | Unconjugated |
Concentration | LYOPH |
Immunogen | Chinese hamster ovary cell line CHO-derived recombinant human ICAM‑1/CD54 Extracellular domain |
Specificity | Detects human ICAM‑1/CD54 in direct ELISAs and Western blots. ICAM‑1/CD54 has been screened using CHO cells transfected with cDNAs for ICAM-1, VCAM-1, and E-Selectin. ICAM‑1/CD54 was shown to be only reactive with ICAM-1. |
Source | N/A |
Isotype | Serum |
Clonality | Polyclonal |
Host | Goat |
Gene | ICAM1 |
Purity Statement | N/A |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Publications |
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Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Buffer | Lyophilized from a 0.2 μm filtered solution in Serum. |
Preservative | No Preservative |
Concentration | LYOPH |
Reconstitution Instructions | Reconstitute in 0.5 mL of sterile water. |
Intercellular Adhesion Molecule-1 (ICAM-1, CD54) binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma , TNF-alpha , IL-1 beta and LPS.
Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, LAD, cancer and transplantation.
Secondary Antibodies |
Isotype Controls |
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Gene Symbol | ICAM1 |