Human Thrombospondin-2 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Thrombospondins (TSP) are secreted multidomain glycoproteins with many putative functions including modulating cell adhesion, proliferation, migration, and angiogenesis. At least five TSPs exist: TSP-1, -2, -3, -4, and cartilage oligomeric glycoprotein (COMP)/TSP-5. The family can be divided into two subgroups. The first, TSP-1 and -2, are homotrimeric molecules, each monomer containing an N-terminal/heparin-binding domain, a coiled-coil oligomerization domain, a von Willebrand factor-type/procollagen homology domain, three type 1 thrombospondin repeats (TSR), three EGF-like repeats, seven TSP type 3 repeats, and a C-terminal globular domain. TSP-1 and -2 are thought to mediate interactions between cells and the extracellular matrix, and as such are matricellular proteins. In contrast, TSP-3, -4, and COMP/TSP-5 are homopentamers that lack the N-terminal structure of TSP-1 and -2, but have a similar arrangement of EGF and TSP type 3 repeats, and the C-terminal domain characteristic of the TSP family.

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 8 of 8.

Publications using DTSP20	Applications	Species
T Matsumae, T Kodama, Y Tahata, Y Myojin, A Doi, A Nishio, R Yamada, Y Nozaki, M Oshita, N Hiramatsu, N Morishita, K Ohkawa, T Hijioka, M Sakakibara, Y Doi, N Kakita, T Yakushijin, R Sakamori, H Hikita, T Tatsumi, T Takehara Thrombospondin-2 as a Predictive Biomarker for Hepatocellular Carcinoma after Hepatitis C Virus Elimination by Direct-Acting Antiviral Cancers, 2023-01-11;15(2):. 2023-01-11 [PMID: 36672412] (Human)		Human
T Iwadare, T Kimura, N Tanaka, T Yamazaki, SI Wakabayash, T Okumura, H Kobayashi, Y Yamashita, SP Pydi, T Nakajima, M Iwaya, A Sugiura, S Joshita, T Uehara, T Umemura Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients Scientific Reports, 2022-11-07;12(1):18900. 2022-11-07 [PMID: 36344733] (Human)		Human
J Luther, AG Vannier, EA Schaefer, RP Goodman The circulating proteomic signature of alcohol-associated liver disease JCI Insight, 2022-07-22;7(14):. 2022-07-22 [PMID: 35866482] (Human)		Human
R Samain, A Brunel, T Douché, M Fanjul, S Cassant-So, J Rochotte, J Cros, C Neuzillet, J Raffenne, C Duluc, A Perraud, J Nigri, V Gigoux, I Bieche, M Ponzo, G Carpentier, I Cascone, R Tomasini, HA Schmid, M Mathonnet, R Nicolle, MP Bousquet, Y Martineau, S Pyronnet, C Jean, C Bousquet Pharmacological normalization of pancreatic cancer-associated fibroblast secretome impairs pro-metastatic cross-talk with macrophages: Stromal CSF-1 facilitates metastasis Cellular and Molecular Gastroenterology and Hepatology, 2021-01-20;0(0):. 2021-01-20 [PMID: 33482394] (Human)		Human
AW Berger, D Schwerdel, A Reinacher-, W Uhl, H Algül, H Friess, KP Janssen, A König, M Ghadimi, E Gallmeier, DK Bartsch, M Geissler, L Staib, A Tannapfel, A Kleger, A Beutel, LA Schulte, M Kornmann, TJ Ettrich, T Seufferlei A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer Theranostics, 2019-02-12;9(5):1280-1287. 2019-02-12 [PMID: 30867830] (Human)		Human
S Yang, R Song, X Li, T Zhang, J Fu, X Cui Thrombospondin-2 predicts response to treatment with intravenous immunoglobulin in children with Kawasaki disease BMJ Paediatr Open, 2018-01-03;2(1):e000190. 2018-01-03 [PMID: 29637185] (Human)		Human
Hanatani S, Izumiya Y, Takashio S, Kimura Y, Araki S, Rokutanda T, Tsujita K, Yamamoto E, Tanaka T, Yamamuro M, Kojima S, Tayama S, Kaikita K, Hokimoto S, Ogawa H Circulating thrombospondin-2 reflects disease severity and predicts outcome of heart failure with reduced ejection fraction. Circ J, 2014-02-06;78(4):903-10. 2014-02-06 [PMID: 24500070] (Human)		Human
Farrow B, Berger DH, Rowley D Tumor-derived pancreatic stellate cells promote pancreatic cancer cell invasion through release of thrombospondin-2. J. Surg. Res., 2009-05-03;156(1):155-60. 2009-05-03 [PMID: 19592030] (Human)		Human

Array DTSP20

• Thrombospondin-2 Antibodies
• Thrombospondin-2 Lysate
• Thrombospondin-2 Protein
• Thrombospondin-2 Proteins and Enzyme
• Thrombospondin-2 ELISAs