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Human sE-Selectin/CD62E Quantikine ELISA Kit

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Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Human sE-Selectin/CD62E Quantikine ELISA Kit Summary

Background
The Quantikine Human sE-Selectin immunoassay is a 4.5 hour solid phase ELISA designed to measure sE-Selectin in cell culture supernates, serum, and plasma. It contains CHO cell-expressed recombinant human sE-Selectin and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human sE-Selectin showed linear curves that were parallel to the standard curv...es obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human sE-Selectin.
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Specificity
Natural and recombinant human sE-Selectin
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
SELE

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DSLE00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human sE-Selectin/CD62E Quantikine ELISA Kit

  • CD62 antigen-like family member E
  • CD62E antigen
  • CD62E
  • ELAM
  • ELAM1
  • ELAM-1
  • ELAM1E-selectin
  • endothelial adhesion molecule 1
  • Endothelial leukocyte adhesion molecule 1
  • ESEL
  • E-Selectin
  • LECAM2
  • leukocyte endothelial cell adhesion molecule 2
  • Leukocyte-endothelial cell adhesion molecule 2
  • SELE
  • selectin E

Background

The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The human and rat proteins share approximately 67% amino acid sequence identity. The mouse and rat proteins share approximately 78% amino acid sequence identity. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. Human and mouse L-Selectin share 76% amino acid sequence identity. Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is expressed by activated platelets and endothelial cells. The extracellular domains of human and mouse P-Selectin share approximately 73% amino acid sequence identity.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for E-Selectin/CD62E (DSLE00)(51)

We have publications tested in 1 confirmed species: Human.


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Human
(51)
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Showing Publications 1 - 10 of 51. Show All 51 Publications.
Publications using DSLE00 Applications Species
Short, SAP;Wilkinson, K;Long, DL;Crews, DC;Gutierrez, OM;Irvin, MR;Wheeler, M;Cushman, M;Cheung, KL; Endothelial Dysfunction Biomarkers and CKD Incidence in the REGARDS Cohort Kidney international reports 2024-07-01 [PMID: 39081743] (Human) Human
Domingo, JC;Battistini, F;Cordobilla, B;Zaragozá, MC;Sanmartin-Sentañes, R;Alegre-Martin, J;Cambras, T;Castro-Marrero, J; Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study Journal of translational medicine 2024-04-10 [PMID: 38600563] (Human) Human
Krug, J;Bochenek, ML;Gogiraju, R;Laubert-Reh, D;Lackner, KJ;Münzel, T;Wild, PS;Espinola-Klein, C;Schäfer, K; Circulating Soluble EPCR Levels Are Reduced in Patients with Ischemic Peripheral Artery Disease and Associated with Markers of Endothelial and Vascular Function Biomedicines 2023-09-04 [PMID: 37760900] (Human) Human
R Gualtierot, F Tafuri, R Rossio, M Rota, P Bucciarell, B Ferrari, A Giachi, C Suffritti, M Cugno, F Peyvandi, On Behalf Lung Ultrasound Findings and Endothelial Perturbation in a COVID-19 Low-Intensity Care Unit Journal of Clinical Medicine, 2022-09-15;11(18):. 2022-09-15 [PMID: 36143072] (Human) Human
A Orea-Tejad, C Sánchez-Mo, OG Aztatzi-Ag, MP Sierra-Var, D González-I, Y Debray-Gar, MS Ortega-Rom, C Keirns-Dav, L Cornejo-Co, J Aguilar-Me Plasma Endothelial and Oxidative Stress Biomarkers Associated with Late Mortality in Hospitalized COVID-19 Patients Journal of Clinical Medicine, 2022-07-07;11(14):. 2022-07-07 [PMID: 35887714] (Human) Human
L Dion-Alber, A Cadoret, E Doney, FN Kaufmann, KA Dudek, B Daigle, LF Parise, F Cathomas, N Samba, N Hudson, M Lebel, Signature, M Campbell, G Turecki, N Mechawar, C Menard Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue Nature Communications, 2022-01-10;13(1):164. 2022-01-10 [PMID: 35013188] (Human) Human
J Jasiczek, M Trocha, A Derkacz, E Szahidewic, A Doroszko Effect of the Renin-Angiotensin-Aldosterone System Reactivity on Endothelial Function and Modulative Role of Valsartan in Male Subjects with Essential Hypertension Journal of Clinical Medicine, 2021-12-13;10(24):. 2021-12-13 [PMID: 34945112] (Human) Human
S Nawrocka-M, J Biegus, M Hurkacz, M Guzik, M Rosiek-Bie, EA Jankowska, P Ponikowski, R Zymli?ski Differences in the Biomarker Profile of De Novo Acute Heart Failure versus Decompensation of Chronic Heart Failure Biomolecules, 2021-11-16;11(11):. 2021-11-16 [PMID: 34827701] (Human) Human
EI Sakketou, GK Baxevanis, NK Tentolouri, GD Konstanton, VT Karathanos, GA Fragkiadak, PT Kanellos Tahini consumption affects blood pressure and endothelial function in healthy males Journal of human hypertension, 2021-10-27;0(0):. 2021-10-27 [PMID: 34707227] (Human) Human
K Buschmann, Y Gramlich, R Chaban, M Oelze, U Hink, T Münzel, H Treede, A Daiber, GD Duerr Disturbed Lipid Metabolism in Diabetic Patients with Manifest Coronary Artery Disease Is Associated with Enhanced Inflammation International Journal of Environmental Research and Public Health, 2021-10-17;18(20):. 2021-10-17 [PMID: 34682638] (Human) Human
Show All 51 Publications.

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Bioinformatics

Gene Symbol SELE