Human Nesfatin-1/Nucleobindin-2 DuoSet ELISA, 15 Plate

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Nesfatin-1 (NEFA Encoded Satiety and Fat-influencing protein 1) is a secreted, 10 kDa peptide derived from the translation product of the NUCB2 gene. Nesfatin-1 is associated with neurons involved in feeding (ARH and PVH) and fluid intake (SON and PVH), in beta cells of the pancreas, and in adipocytes. Its presence peripherally has an anorexigenic effect. Mature human Nesfatin-1 is 82 amino acids (aa) in length. It is the secreted N-terminus of a larger, intracellular 420 aa precursor termed NEFA/Nucleobindin-2/NUCB2. NUCB2 contains a signal sequence (aa 1- 24), Nesfatin-1 (aa 25-106), a DNA-binding site (aa 171-223), and two EF-hand regions (aa 241-276 and 293-328). Intracellular uncleaved NUCB2 is 45-50 kDa in size. There is a potential for multiple cleavages, generating Nesfatin-2 (aa 109-187) and Nesfatin-3 (aa 190-420). Human Nesfatin-1 shares 85% aa identity with mouse Nesfatin-1.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 5 of 5.

Publications using DY5949	Applications	Species
KD Honoré, S Bruun, LN Jacobsen, M Domellöf, KF Michaelsen, S Husby, G Zachariass Nesfatin-1 in Human Milk and Its Association with Infant Anthropometry Nutrients, 2022-12-30;15(1):. 2022-12-30 [PMID: 36615833] (Human)		Human
BM Giglio, RM Schincagli, AS da Silva, ICS Fazani, PA Monteiro, JF Mota, JP Cunha, C Pichard, GD Pimentel Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study Nutrients, 2019-09-02;11(9):. 2019-09-02 [PMID: 31480676] (Human)		Human
C Robinson, L Tsang, A Solomon, AJ Woodiwiss, S Gunter, M Mer, HC Hsu, M Gomes, GR Norton, AME Millen, PH Dessein Nesfatin-1 and visfatin expression is associated with reduced atherosclerotic disease risk in patients with rheumatoid arthritis Peptides, 2018-02-21;102(0):31-37. 2018-02-21 [PMID: 29475075] (Human)		Human
Nesfatin-1/Nucleobindin-2 enhances cell migration, invasion, and epithelial-mesenchymal transition via LKB1/AMPK/TORC1/ZEB1 pathways in colon cancer Oncotarget, 2016-05-24;7(21):31336-49. 2016-05-24 [PMID: 27150059] (Human)		Human
Dong J, Xu H, Xu H, Wang P, Cai G, Song H, Wang C, Dong Z, Ju Y, Jiang Z Nesfatin-1 stimulates fatty-acid oxidation by activating AMP-activated protein kinase in STZ-induced type 2 diabetic mice. PLoS ONE, 2013-12-31;8(12):e83397. 2013-12-31 [PMID: 24391760] (Mouse)		Mouse

Array DY5949

• Nesfatin-1/Nucleobindin-2 Antibodies
• Nesfatin-1/Nucleobindin-2 ELISA Kits
• Nesfatin-1/Nucleobindin-2 Proteins
• Nesfatin-1/Nucleobindin-2 ELISA