GSK-3 alpha Antibody

Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NB100-81943	Applications	Species
Davulur, G, Giusto M, Chandel R et al. Impaired Ribosomal Biogenesis by Non-Canonical Degradation of beta-catenin during Hyperammonemia Mol. Cell. Biol. 2019-06-17 [PMID: 31138664]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Leeni Koivisto	IP	Human	07/14/2014	View Summary Application Immunoprecipitation Sample Tested HaCaT keratinocyte whole cell lysate Species Human Lot 5117

Array NB100-81943

• GSK-3 alpha Antibodies
• GSK-3 alpha ELISA Kits
• GSK-3 alpha Lysate
• GSK-3 alpha Protein