Tau Antibody (2E9)

Tau is a relatively low molecular weight member of the microtubule associated protein or MAP family. Most of these proteins were discovered since microtubules can be polymerized in cell homogenates and pelleted out by centrifugation, typically taking MAP proteins with them. This early work showed that the Tau protein facilitated the polymerization of microtubules, and was therefore named after the Greek letter tau, since it promoted tubule formation. Tau is heavily concentrated in axons of neurons, but may also be found in dendrites and in some non-neuronal cells. Much interest has focused on Tau as it is a major component of the neurofibrillary tangles of Alzheimer's disease. Tau in neurofibrillary tangles is typically heavily and aberrantly phosphorylated, and it is believed that phosphorylation may be involved in tangle formation. In addition, numerous different point mutations in the Tau gene are causative of Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). There is one mammalian Tau gene which produces at least 9 different proteins by alternate transcription. In the central nervous system 6 isoforms predominant which either include or do not include three short exon coded inserts. These proteins range in size from 352-441 amino acids and run on SDS-PAGE gels as multiple bands ranging from 48-67 kDa. In peripheral nervous system a form called "big tau" predominates, another alternate transcript which includes a 254 amino acid insert. This form of Tau is found in small amounts in the brain also, in cranial nerve motor nuclei and sensory processes of most sensory ganglia, and runs on SDS-PAGE with an apparent molecular weight of 100 kDa. Each Tau protein contains 3 or 4 copies of an 18 amino acid peptide which are responsible for binding to the microtubules and are similar to those found in MAP2 and other members of the MAP family. Tau is a highly charged acidic protein with few hydrophobic residues which belongs to the family of "intrinsically unstructured proteins". As with GAP43, MARCKS and several other similar proteins, Tau isoforms run on SDS-PAGE much more slowly than expected from their actual molecular weight. This antibody was made against a recombinant construct expressed in and purified from E. coli and which corresponded to the shortest version of the various Tau proteins, so this antibody is expected to bind to all Tau isoforms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IHC, PLA.

Showing Publications 1 - 5 of 5.

Publications using NBP2-25162	Applications	Species
Mody PH, Marvin KN, Hynds DL, Hanson LK Cytomegalovirus infection induces Alzheimer's disease-associated alterations in tau Journal of neurovirology 2023-07-12 [PMID: 37436577]
Huang CN, Lin CL, Li HH et al. Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function Journal of medicinal food 2023-06-26 [PMID: 37358589]
Matchett BJ, Lincoln SJ, Baker M et al. The SERPINA5 coding variant E228Q does not contribute to clinicopathologic characteristics in Alzheimer's disease: A cross-sectional study Medicine 2023-06-16 [PMID: 37327267] (IHC, Human)	IHC	Human
El-Nashar HAS, Abbas H, Zewail M et al. Neuroprotective Effect of Artichoke-Based Nanoformulation in Sporadic Alzheimer's Disease Mouse Model: Focus on Antioxidant, Anti-Inflammatory, and Amyloidogenic Pathways Pharmaceuticals (Basel, Switzerland) 2022-09-28 [PMID: 36297313]
Pandya NJ, Meier S, Tyanova S Et al. A cross-species spatiotemporal proteomic analysis identifies UBE3A-dependent signaling pathways and targets Mol Psychiatry 2022-03-10 [PMID: 35264729] (PLA, Human) Details: Citation using the Alexa Fluor 647 version of this antibody.	PLA	Human

Array NBP2-25162

• Tau Antibodies
• Tau ELISA Kits
• Tau Lysates
• Tau Proteins
• Tau Proteins and Enzymes