GluR5/GRIK1 Antibody - BSA Free

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using NBP1-76849	Applications	Species
Sareddy GR, Pratap UP, Venkata PP, et al. Activation of estrogen receptor beta signaling reduces stemness of glioma stem cells Stem cells (Dayton, Ohio) 2021-01-20 [PMID: 33470499]

Array NBP1-76849

• GluR5/GRIK1 Antibodies
• GluR5/GRIK1 Lysate
• GluR5/GRIK1 Proteins