Endostatin Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Porcine.

We have publications tested in 3 applications: IHC-Fr, IHC-P, Western Blot.

Showing Publications 1 - 7 of 7.

Publications using AF1098	Applications	Species
S Sharma, T Watanabe, T Nishimoto, T Takihara, L Mlakar, XX Nguyen, M Sanderson, Y Su, RA Chambers, C Feghali-Bo E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects JCI Insight, 2021-12-22;6(24):. 2021-12-22 [PMID: 34935642] (Western Blot, Human)	Western Blot	Human
Rickelt S, Neyaz A, Condon C et al. Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker Clinical Cancer Research 2022-03-15 [PMID: 34785582]
M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue Eur J Vasc Endovasc Surg, 2018-04-12;0(0):. 2018-04-12 [PMID: 29656960] (IHC-Fr, Human)	IHC-Fr	Human
Baruah P, Lee M, Wilson P, Odutoye T, Williamson P, Hyde N, Kaski J, Dumitriu I Impact of p16 status on pro- and anti-angiogenesis factors in head and neck cancers. Br J Cancer, 2015-07-14;113(4):653-9. 2015-07-14 [PMID: 26171937] (IHC-P, Human)	IHC-P	Human
Ahmet Okay Caglayan, Jacob F. Baranoski, Fesih Aktar, Wengi Han, Beyhan Tuysuz, Aslan Guzel et al. Brain malformations associated with Knobloch syndrome--review of literature, expanding clinical spectrum, and identification of novel mutations Pediatric Neurology 2014-12-01 [PMID: 25456301]
Ohlund D, Ardnor B, Oman M, Naredi P, Sund M Expression pattern and circulating levels of endostatin in patients with pancreas cancer. Int. J. Cancer, 2008-06-15;122(12):2805-10. 2008-06-15 [PMID: 18360823] (IHC-Fr, Human)	IHC-Fr	Human
Bartsch G, Eggert K, Soker S, Bokemeyer C, Hautmann R, Schuch G Combined antiangiogenic therapy is superior to single inhibitors in a model of renal cell carcinoma. J. Urol., 2007-11-19;179(1):326-32. 2007-11-19 [PMID: 18006013] (Western Blot, Porcine)	Western Blot	Porcine

Array AF1098

• Endostatin Antibodies
• Endostatin ELISA Kits
• Endostatin Proteins
• Endostatin Proteins and Enzymes
• Endostatin ELISAs