E-Selectin/CD62E Antibody (96419)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

E-Selectin (Endothelial Leukocyte Adhesion Molecule-1, ELAM-1, CD62E), a member of the Selectin family, is a 107 - 115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha , and demonstrates peak expression at 4 hours, and decay at 24 hours, in response to activation. E-Selectin ligands, expressed on neutrophils, monocytes, and a subset of memory T cells, are sialylated, fucosylated molecules which bind to the lectin domain of E-Selectin. Immunocytochemical techniques have demonstrated the expression of E-Selectin on healthy and diseased tissue. The human and mouse E‑Selectin proteins share 81% amino acid similarity.

E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall during inflammation by binding to E-Selectin ligands on leukocytes. These interactions are labile and permit leukocytes to roll along the vascular endothelium in the direction of blood flow. This initial interaction is followed by a stronger interaction involving ICAM-1 and VCAM-1 that leads eventually to extravasation of the white blood cell through the blood vessel wall into the extracellular matrix tissue.

ELISA techniques have shown that detectable levels of soluble E-Selectin are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: IHC, IHC-Fr, Neutralization, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using MAB5751	Applications	Species
K Kajiwara, Y Sawa, T Fujita, S Tamaoki Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy Bmc Nephrology, 2021-01-06;22(1):3. 2021-01-06 [PMID: 33407253] (IHC, Mouse)	IHC	Mouse
N Mondal, M Silva, AP Castano, MV Maus, R Sackstein Glycoengineering of Chimeric Antigen Receptor (CAR) T-cells to Enforce E-selectin Binding J. Biol. Chem., 2019-10-18;0(0):. 2019-10-18 [PMID: 31628196] (Western Blot, Human)	Western Blot	Human
M De Niz, E Meibalan, P Mejia, S Ma, NMB Brancucci, C Agop-Nerse, R Mandt, P Ngotho, KR Hughes, AP Waters, C Huttenhowe, JR Mitchell, R Martinelli, F Frischknec, KB Seydel, T Taylor, D Milner, VT Heussler, M Marti Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow Sci Adv, 2018-05-23;4(5):eaat3775. 2018-05-23 [PMID: 29806032] (Neutralization, Mouse)	Neutralization	Mouse
Kato N, Yuzawa Y, Kosugi T The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. J. Am. Soc. Nephrol., 2009-05-14;20(7):1565-76. 2009-05-14 [PMID: 19443639] (IHC-Fr, Western Blot, Mouse)	IHC-Fr, Western Blot	Mouse

Array MAB5751

• E-Selectin/CD62E Antibodies
• E-Selectin/CD62E Antibody Pairs
• E-Selectin/CD62E ELISA Kits
• E-Selectin/CD62E Lysate
• E-Selectin/CD62E Proteins and Enzymes
• E-Selectin/CD62E ELISAs