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DLEC/CLEC4C/BDCA-2 Antibody (BIIB059) - Humanized

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Immobilized Ma CLEC4C His at 2 ug/mL can bind DLEC/CLEC4C/BDCA-2 Antibody (BIIB059) - Humanized, EC50=0.04315 ug/mL.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, Func
Clone
BIIB059
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated
Concentration
LYOPH

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DLEC/CLEC4C/BDCA-2 Antibody (BIIB059) - Humanized Summary

Description
Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 146.62 kDa.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Additional Information
Recombinant Monoclonal Antibody
Immunogen
CLEC4C
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Gene
CLEC4C
Purity
Protein A purified
Endotoxin Note
< 0.001EU/ug,determined by LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A purified
Reconstitution Instructions
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for DLEC/CLEC4C/BDCA-2 Antibody (BIIB059) - Humanized

  • BDCA2
  • BDCA-2
  • BDCA2MGC125791
  • blood dendritic cell antigen 2 protein
  • Blood dendritic cell antigen 2
  • CD303 antigen
  • CD303
  • CLEC4C
  • CLECSF11
  • CLECSF11PRO34150
  • CLECSF7
  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 11
  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 7
  • C-type lectin domain family 4 member C
  • C-type lectin superfamily member 7
  • dendritic cell lectin b
  • Dendritic lectin
  • DLEC
  • DLECMGC125792
  • HECL
  • HECLMGC125793
  • MGC125789
  • PRO34150

Background

Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CLEC4C
Uniprot