IL-3R alpha/CD123 Antibody (32703) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-3 is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors (1, 2). IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123) and a 120-140 kDa IL-3 R beta subunit (CD131) (3, 4). IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta , however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL‑3 R beta chain has a very large cytoplasmic domain. The IL‑3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 4 applications: Flow Cytometry, IHC-Fr, Neutralization, Western Blot.

Showing Publications 1 - 10 of 10.

Publications using MAB301	Applications	Species
M Koni, I Castellano, E Venturelli, A Sarcinella, T Lopatina, C Grange, M Cedrino, S Femminò, P Cossu-Rocc, S Orrù, F D'Ascenzo, I Cotellessa, C Tampieri, C Debernardi, G Cugliari, G Matullo, G Camussi, MR De Miglio, MF Brizzi Interleukin-3-Receptor-alpha in Triple-Negative Breast Cancer (TNBC): An Additional Novel Biomarker of TNBC Aggressiveness and a Therapeutic Target Cancers, 2022-08-13;14(16):. 2022-08-13 [PMID: 36010912] (Western Blot, Human)	Western Blot	Human
T Lopatina, C Grange, C Cavallari, V Navarro-Ta, G Lombardo, A Rosso, M Cedrino, MAC Pomatto, M Koni, F Veneziano, I Castellano, G Camussi, MF Brizzi Targeting IL-3R&alpha on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming Oncogenesis, 2020-10-10;9(10):90. 2020-10-10 [PMID: 33040091] (Neutralization, Human)	Neutralization	Human
J Chen, YR Kao, D Sun, TI Todorova, D Reynolds, SR Narayanaga, C Montagna, B Will, A Verma, AU Steidl Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level Nat. Med., 2018-12-03;0(0):. 2018-12-03 [PMID: 30510255] (Flow Cytometry, Human)	Flow Cytometry	Human
SE Broughton, TR Hercus, TL Nero, WL Kan, EF Barry, M Dottore, KS Cheung Tun, CJ Morton, U Dhagat, MP Hardy, NJ Wilson, MT Downton, C Schieber, TP Hughes, AF Lopez, MW Parker A dual role for the N-terminal domain of the IL-3 receptor in cell signalling Nat Commun, 2018-01-26;9(1):386. 2018-01-26 [PMID: 29374162] (Flow Cytometry)	Flow Cytometry
A Barhanpurk, ST Mhaske, ST Pote, K Singh, MR Wani Interleukin-3 enhances the migration of human mesenchymal stem cells by regulating expression of CXCR4 Stem Cell Res Ther, 2017-07-14;8(1):168. 2017-07-14 [PMID: 28705238] (Flow Cytometry, Human)	Flow Cytometry	Human
Almut Meyer-Bahl Human Basophils Modulate Plasma Cell Differentiation and Maturation J. Immunol., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852746] (Neutralization, Human)	Neutralization	Human
Activated Stat5 trafficking Via Endothelial Cell-derived Extracellular Vesicles Controls IL-3 Pro-angiogenic Paracrine Action Sci Rep, 2016-05-09;6(0):25689. 5/9/2016 [PMID: 27157262]
M Gschweitl, A Ulbricht, CA Barnes, RI Enchev, I Stoffel-St, N Meyer-Scha, J Huotari, Y Yamauchi, UF Greber, A Helenius, M Peter A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes Elife, 2016-03-23;5(0):. 3/23/2016 [PMID: 27008177]
Leskela S, Serrano A, de la Fuente H, Rodriguez-Munoz A, Ramos-Levi A, Sampedro-Nunez M, Sanchez-Madrid F, Gonzalez-Amaro R, Marazuela M Graves' disease is associated with a defective expression of the immune regulatory molecule galectin-9 in antigen-presenting dendritic cells. PLoS ONE, 2015-04-16;10(4):e0123938. 2015-04-16 [PMID: 25880730] (IHC-Fr, Human)	IHC-Fr	Human
Bovolenta C, Pilotti E, Mauri M, Turci M, Ciancianaini P, Fisicaro P, Bertazzoni U, Poli G, Casoli C Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor. Blood, 2002-01-01;99(1):224-31. 2002-01-01 [PMID: 11756175] (Neutralization, Human)	Neutralization	Human

Array MAB301

• IL-3R alpha/CD123 Antibodies
• IL-3R alpha/CD123 Antibody Pair
• IL-3R alpha/CD123 Lysate
• IL-3R alpha/CD123 Proteins
• IL-3R alpha/CD123 Proteins and Enzymes