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CXCR4 Antibody [DyLight 650]

 
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Simple Western
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 650

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77560AF350
Alexa Fluor 405
NBP1-77560AF405
Alexa Fluor 488
NBP1-77560AF488
Alexa Fluor 532
NBP1-77560AF532
Alexa Fluor 594
NBP1-77560AF594
Alexa Fluor 647
NBP1-77560AF647
Alexa Fluor 700
NBP1-77560AF700
Alexa Fluor 750
NBP1-77560AF750
Allophycocyanin
NBP1-77560APC
Biotin
NBP1-77560B
DyLight 350
NBP1-77560UV
DyLight 405
NBP1-77560V
DyLight 488
NBP1-77560G
DyLight 550
NBP1-77560R
DyLight 594
NBP1-77560DL594
DyLight 680
NBP1-77560FR
DyLight 755
NBP1-77560IR
HRP
NBP1-77560H
Janelia Fluor 549
NBP1-77560JF549
Janelia Fluor 646
NBP1-77560JF646
PE
NBP1-77560PE
PerCP
NBP1-77560PCP
Unconjugated
NBP1-77560
mFluor Violet 450 SE
NBP1-77560MFV450
mFluor Violet 500 SE
NBP1-77560MFV500
mFluor Violet 610 SE
NBP1-77560MFV610
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CXCR4 Antibody [DyLight 650] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human CXCR4 protein (between residues 300-352) [UniProt# P61073]
Localization
Cell membrane.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CXCR4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for CXCR4 Antibody [DyLight 650]

  • CD184
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • C-X-C chemokine receptor type 4
  • CXCR4
  • CXC-R4
  • CXCR-4
  • D2S201E
  • D2S201ESDF-1 receptor
  • FB22
  • Fusin
  • HM89
  • HM89NPYRL
  • HSY3RR
  • LAP3
  • LAP-3
  • LCR1
  • LESTR
  • LESTRCD184 antigen
  • Leukocyte-derived seven transmembrane domain receptor
  • leukocyte-derived seven-transmembrane-domain receptor
  • lipopolysaccharide-associated protein 3
  • neuropeptide Y receptor Y3
  • NPY3R
  • NPY3RWHIM
  • NPYR
  • NPYRL
  • NPYY3R
  • pCXCR4
  • seven transmembrane helix receptor
  • seven-transmembrane-segment receptor, spleen
  • Stromal cell-derived factor 1 receptor
  • WHIMS

Background

CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T cell tropic strains of HIV1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV1 and mediates CD4 independent infection by HIV2. The a chemokine SDF1 is the ligand for CXCR4 and prevents infection by T tropic HIV1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV1 and HIV2 fusion and infection of human target cells. The amino terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites. CXCR4 is highly expressed in brain and heart, and in white blood cells, vascular endothelial cells, and umbilical cord endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CXCR4 Antibody
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NBP1-77560C
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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for CXCR4 Antibody (NBP1-77560C). (Showing 1 - 1 of 1 FAQ).

  1. Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
    • CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

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Bioinformatics

Gene Symbol CXCR4