Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.

Name: CXCR4 Antibody (247506) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB21651
Rating: 4 (1 reviews)

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Accepted Answer

CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	Flow, IHC, B/N, CyTOF-ready, ICC/IF
Clone	247506
Clonality	Monoclonal
Host	Rat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB21651U-100UG

Alexa Fluor 405 FAB21651V-100UG

Alexa Fluor 488 FAB21651G-100UG

Alexa Fluor 532 FAB21651X

Alexa Fluor 594 FAB21651T-100UG

Alexa Fluor 647 FAB21651R-100UG

Alexa Fluor 700 FAB21651N-100UG

Alexa Fluor 750 FAB21651S-100UG

Allophycocyanin FAB21651A-100UG

Allophycocyanin FAB21651A-025UG

Allophycocyanin/Cy7 FAB21651APCCY7

Biotin FAB21651B

CoraFluor 1 FAB21651CL1

DyLight 350 FAB21651D

DyLight 405 FAB21651E

DyLight 488 FAB21651K

DyLight 550 FAB21651L

DyLight 594 FAB21651M

DyLight 650 FAB21651W

DyLight 680 FAB21651Y

DyLight 755 FAB21651Z

Fluorescein FAB21651F-100

Fluorescein FAB21651F-025

HRP FAB21651H

Janelia Fluor 525 FAB21651JF525

Janelia Fluor 549 FAB21651I

Janelia Fluor 585 FAB21651JF585

Janelia Fluor 635 FAB21651JF635

Janelia Fluor 646 FAB21651J

Janelia Fluor 669 FAB21651JF669

PE/Atto594 FAB21651PEATT594

PE/Cy5.5 FAB21651PECY55

PE/Cy7 FAB21651PECY7

Phycoerythrin FAB21651P-100

Phycoerythrin FAB21651P-025

mFluor Violet 450 SE FAB21651MFV450

mFluor Violet 500 SE FAB21651MFV500

mFluor Violet 610 SE FAB21651MFV610

Catalog# & Formulation	Size	Price
Carrier Free FAB21651T-100UG

Carrier Free FAB21651A-100UG

Carrier Free FAB21651V-100UG

Carrier Free FAB21651G-100UG

Carrier Free FAB21651N-100UG

Carrier Free FAB21651R-100UG

Carrier Free FAB21651S-100UG

Carrier Free FAB21651U-100UG

Carrier Free FAB21651F-025

Carrier Free MAB21651-500

Carrier Free MAB21651-SP

Carrier Free FAB21651P-100

Carrier Free FAB21651P-025

Carrier Free FAB21651F-100

Carrier Free FAB21651A-025UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB21651U-100UG
Alexa Fluor 405	FAB21651V-100UG
Alexa Fluor 488	FAB21651G-100UG
Alexa Fluor 532	FAB21651X
Alexa Fluor 594	FAB21651T-100UG
Alexa Fluor 647	FAB21651R-100UG
Alexa Fluor 700	FAB21651N-100UG
Alexa Fluor 750	FAB21651S-100UG
Allophycocyanin	FAB21651A-025UG
Allophycocyanin	FAB21651A-100UG
Allophycocyanin/Cy7	FAB21651APCCY7
Biotin	FAB21651B
CoraFluor 1	FAB21651CL1
DyLight 350	FAB21651D
DyLight 405	FAB21651E
DyLight 488	FAB21651K
DyLight 550	FAB21651L
DyLight 594	FAB21651M
DyLight 650	FAB21651W
DyLight 680	FAB21651Y
DyLight 755	FAB21651Z
Fluorescein	FAB21651F-100
Fluorescein	FAB21651F-025
HRP	FAB21651H
Janelia Fluor 525	FAB21651JF525
Janelia Fluor 549	FAB21651I
Janelia Fluor 585	FAB21651JF585
Janelia Fluor 635	FAB21651JF635
Janelia Fluor 646	FAB21651J
Janelia Fluor 669	FAB21651JF669
PE/Atto594	FAB21651PEATT594
PE/Cy5.5	FAB21651PECY55
PE/Cy7	FAB21651PECY7
Phycoerythrin	FAB21651P-100
Phycoerythrin	FAB21651P-025
mFluor Violet 450 SE	FAB21651MFV450
mFluor Violet 500 SE	FAB21651MFV500
mFluor Violet 610 SE	FAB21651MFV610

CXCR4 Antibody (247506) [Unconjugated]

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Publications for CXCR4 Antibody (MAB21651)(45)

Review for CXCR4 Antibody (MAB21651) (1) 41

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Immunogen	Y3 rat myeloid cell line transfected with mouse CXCR4 Met1-Ser359 Accession # P70658
Specificity	Detects mouse CXCR4 transfectants. Does not stain irrelevant transfectants.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Rat
Gene	CXCR4
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB21651	Applications	Species
PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas The ocular surface, 2023;28(0):99-107. 2023 [PMID: 36813133] (IHC, Mouse)	IHC	Mouse
PK Suvas, M Setia, M Rana, A Chakrabort, S Suvas Novel characterization of CXCR4 expressing cells in uninfected and herpes simplex virus-1 infected corneas The ocular surface, 2023-02-20;28(0):99-107. 2023-02-20 [PMID: 36813133] (IHC, Mouse)	IHC	Mouse
Prakash Narayan, Andrew T. Bruce, Elias A. Rivera, Timothy A. Bertram, Deepak Jain Selected renal cells harbor nephrogenic potential Frontiers in Medicine 12/22/2022 [PMID: 36619635]
Neele Babst, Lisa K. Isbell, Felix Rommel, Aysegul Tura, Mahdy Ranjbar, Salvatore Grisanti et al. CXCR4, CXCR5 and CD44 May Be Involved in Homing of Lymphoma Cells into the Eye in a Patient Derived Xenograft Homing Mouse Model for Primary Vitreoretinal Lymphoma International Journal of Molecular Sciences 2022-10-04 [PMID: 36233057]
Y Xu, Z Wei, M Feng, D Zhu, S Mei, Z Wu, Q Feng, W Chang, M Ji, C Liu, Y Zhu, L Shen, F Yang, Y Chen, Y Feng, J Xu, D Zhu Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers Cell Reports, 2022-08-30;40(9):111295. 2022-08-30 [PMID: 36044847] (In Vivo, Mouse)	In Vivo	Mouse
Connor P. Dolan, Felisha Imholt, Mingquan Yan, Tae-Jung Yang, Joshua Gregory, Osama Qureshi et al. Digit specific denervation does not inhibit mouse digit tip regeneration Developmental Biology 2022-06-01 [PMID: 35353991]
LA Ridge, D Kewbank, D Schütz, R Stumm, PJ Scambler, S Ivins Dual role for CXCL12 signaling in semilunar valve development Cell Reports, 2021-08-24;36(8):109610. 2021-08-24 [PMID: 34433040] (IHC, Mouse)	IHC	Mouse
J Kim, SW Lee, K Park CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands International Journal of Molecular Sciences, 2021-01-10;22(2):. 2021-01-10 [PMID: 33435128] (ICC, Mouse)	ICC	Mouse
Drew R. Seeger, Svetlana A. Golovko, Bryon D. Grove, Mikhail Y. Golovko Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia Journal of Neurochemistry 2021-07-01 [PMID: 33389746]
Jorge Luis Galeano Niño, Sophie V Pageon, Szun S Tay, Feyza Colakoglu, Daryan Kempe, Jack Hywood et al. Cytotoxic T cells swarm by homotypic chemokine signalling eLife 10/13/2020 [PMID: 33046212]
S Davidson, M Efremova, A Riedel, B Mahata, J Pramanik, J Huuhtanen, G Kar, R Vento-Torm, T Hagai, X Chen, MA Haniffa, JD Shields, SA Teichmann Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth Cell Rep, 2020-05-19;31(7):107628. 5/19/2020 [PMID: 32433953]
Saria Mcheik, Nils Van Eeckhout, Cédric De Poorter, Céline Galés, Marc Parmentier, Jean-Yves Springael Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing Frontiers in Immunology 2019-12-18 [PMID: 31921208]
G Kalpana, C Figy, M Yeung, KC Yeung Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling Sci Rep, 2019-11-08;9(1):16351. 2019-11-08 [PMID: 31705019] (IHC-P, Mouse)	IHC-P	Mouse
ML Capitano, N Mor-Vaknin, AK Saha, S Cooper, M Legendre, H Guo, R Contreras-, F Kappes, MA Sartor, CT Lee, X Huang, DM Markovitz, HE Broxmeyer Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling J. Clin. Invest., 2019-05-20;130(0):2555-2570. 2019-05-20 [PMID: 31107242] (Neutralization, Mouse)	Neutralization	Mouse
Jill A. Macoska, Zunyi Wang, Johanna Virta, Nicholas Zacharias, Dale E. Bjorling Inhibition of the CXCL12/CXCR4 axis prevents peri-urethral collagen accumulation and lower urinary tract dysfunction in vivo The Prostate 2019-05-01 [PMID: 30811623]
MJ Lopez, Y Seyed-Raza, A Jamali, DL Harris, P Hamrah The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c+ Conventional Dendritic Cells Into the Inflamed Murine Cornea Invest. Ophthalmol. Vis. Sci., 2018-11-01;59(13):5671-5681. 2018-11-01 [PMID: 30489627] (Flow Cytometry, IHC, Mouse)	Flow Cytometry, IHC	Mouse
Lindsay A. Dawson, Paula P. Schanes, Patrick Kim, Felisha M. Imholt, Osama Qureshi, Connor P. Dolan et al. Blastema formation and periosteal ossification in the regenerating adult mouse digit Wound Repair and Regeneration 2018-05-08 [PMID: 30120800]
A Benedicto, I Romayor, B Arteta CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver Oncol. Rep., 2018-02-08;0(0):. 2/8/2018 [PMID: 29436696]
H Nagashima, M Shinoda, K Honda, N Kamio, A Hasuike, N Sugano, Y Arai, S Sato, K Iwata CXCR4 signaling contributes to alveolar bone resorption in Porphyromonas gingivalis-induced periodontitis in mice J Oral Sci, 2017-10-31;0(0):. 2017-10-31 [PMID: 29093284] (Neutralization, Mouse)	Neutralization	Mouse
Lindsay A. Dawson, Ling Yu, Mingquan Yan, Luis Marrero, Paula P. Schanes, Connor Dolan et al. The periosteal requirement and temporal dynamics of BMP2‐induced middle phalanx regeneration in the adult mouse Regeneration (Oxf) 2017-08-20 [PMID: 28975034]
M Zhang, L Qiu, Y Zhang, D Xu, JC Zheng, L Jiang CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells Sci Rep, 2017-08-15;7(1):8289. 2017-08-15 [PMID: 28811579] (Bioassay, Human)	Bioassay	Human
A Saha, S Ahn, J Blando, F Su, MG Kolonin, J DiGiovanni Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in obese mice Cancer Res., 2017-07-07;0(0):. 2017-07-07 [PMID: 28687617] (IHC, Mouse)	IHC	Mouse
H Nagashima, M Shinoda, K Honda, N Kamio, M Watanabe, T Suzuki, N Sugano, S Sato, K Iwata CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice Mol Pain, 2017-01-01;13(0):1744806916689. 2017-01-01 [PMID: 28326928] (IHC-Fr, Neutralization, Mouse)	IHC-Fr, Neutralization	Mouse
N Smith, N Pietrancos, S Davidson, J Dutrieux, L Chauveau, P Cutolo, M Dy, D Scott-Alga, B Manoury, O Zirafi, I McCort-Tra, T Durroux, F Bachelerie, O Schwartz, J Münch, A Wack, S Nisole, JP Herbeuval Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement Nat Commun, 2017-02-09;8(0):14253. 2017-02-09 [PMID: 28181493] (ICC, Mouse)	ICC	Mouse
KI Cho, D Yoon, S Qiu, Z Danziger, WM Grill, WC Wetsel, PA Ferreira Loss of Ranbp2 in motor neurons causes the disruption of nucleocytoplasmic and chemokine signaling and proteostasis of hnRNPH3 and Mmp28, and the development of amyotrophic lateral sclerosis (ALS)-like syndromes Dis Model Mech, 2017-01-18;0(0):. 2017-01-18 [PMID: 28100513] (ICC, Mouse)	ICC	Mouse
A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways Sci Rep, 2016-05-09;6(0):25104. 2016-05-09 [PMID: 27157261] (IHC, Mouse)	IHC	Mouse
Uchenna John Unachukwu, Alice Warren, Ze Li, Shawn Mishra, Jing Zhou, Moira Sauane et al. Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina Scientific Reports 2016-03-03 [PMID: 26935401]
Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, Zhu B, Huang Y, Zheng J CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4. Stem Cells, 2015-05-13;33(8):2574-85. 2015-05-13 [PMID: 25833331] (IHC, Mouse)	IHC	Mouse
Spada R, Rojas J, Perez-Yague S, Mulens V, Cannata-Ortiz P, Bragado R, Barber D NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol, 2015-01-12;97(3):583-98. 2015-01-12 [PMID: 25583577] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Butschkau , Antje, Wagner , Nana-Mar, Genz , Berit, Vollmar , Brigitte Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS ONE, 2014-12-04;9(12):e113554. 2014-12-04 [PMID: 25474349] (ICC, Human)	ICC	Human
DeNiro M, Al-Mohanna F Nuclear factor kappa-B signaling is integral to ocular neovascularization in ischemia-independent microenvironment. PLoS ONE, 2014-07-22;9(7):e101602. 2014-07-22 [PMID: 25050547] (IHC-P, Mouse)	IHC-P	Mouse
Zgraggen , Silvana, Huggenberger , Reto, Kerl , Katrin, Detmar , Michael An important role of the SDF-1/CXCR4 axis in chronic skin inflammation. PLoS ONE, 2014-04-02;9(4):e93665. 2014-04-02 [PMID: 24695674] (IHC, Mouse)	IHC	Mouse
Roy , Lopamudr, Sahraei , Mahnaz, Schettini , Jorge L, Gruber , Helen E, Besmer , Dahlia M, Mukherjee , Pinku Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches. BMC Cancer, 2014-03-27;14(0):225. 2014-03-27 [PMID: 24674692] (Neutralization, Mouse)	Neutralization	Mouse
Kavanagh D, Yemm A, Zhao Y, Frampton J, Kalia N Mechanisms of adhesion and subsequent actions of a haematopoietic stem cell line, HPC-7, in the injured murine intestinal microcirculation in vivo. PLoS ONE, 2013-03-12;8(3):e59150. 2013-03-12 [PMID: 23554986] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Yang , Qi-En, Kim , Dongwon, Kaucher , Amy, Oatley , Melissa, Oatley , Jon M CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells. J Cell Sci, 2012-12-13;126(0):1009-20. 2012-12-13 [PMID: 23239029] (Flow Cytometry, ICC, Mouse)	Flow Cytometry, ICC	Mouse
Kohler T, Reizis B, Johnson RS, Weighardt H, Forster I Influence of hypoxia-inducible factor 1-alpha on dendritic cell differentiation and migration. Eur. J. Immunol., 2012-05-01;42(5):1226-36. 2012-05-01 [PMID: 22539295] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Liu H, Liu S, Li Y, Wang X, Xue W, Ge G, Luo X The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS ONE, 2012-04-12;7(4):e34608. 2012-04-12 [PMID: 22511954] (Neutralization, Mouse)	Neutralization	Mouse
Salvucci O, Jiang K, Gasperini P MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1. Haematologica, 2012-01-22;97(6):818-26. 2012-01-22 [PMID: 22271895] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation. J. Immunol., 2011-09-19;187(9):4835-43. 2011-09-19 [PMID: 21930960] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Liu H, Xue W, Ge G, Luo X, Li Y, Xiang H, Ding X, Tian P, Tian X Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1alpha in MSCs. Biochem. Biophys. Res. Commun., 2010-09-24;401(4):509-15. 2010-09-24 [PMID: 20869949] (Neutralization, Mouse)	Neutralization	Mouse
Strasser GA, Kaminker JS, Tessier-Lavigne M Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood, 2010-02-12;115(24):5102-10. 2010-02-12 [PMID: 20154215] (Neutralization, Mouse)	Neutralization	Mouse
Sengupta N, Afzal A, Caballero S, Chang KH, Shaw LC, Pang JJ, Bond VC, Bhutto I, Baba T, Lutty GA, Grant MB Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest. Ophthalmol. Vis. Sci., 2009-12-10;51(5):2697-704. 2009-12-10 [PMID: 20007826] (Neutralization, Mouse)	Neutralization	Mouse
Schroeter MR, Humboldt T, Schafer K, Konstantinides S Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice. Atherosclerosis, 2008-11-25;205(1):63-73. 2008-11-25 [PMID: 19111832] (IHC, Mouse)	IHC	Mouse
Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J. Cell Biol., 2008-12-15;183(6):1145-57. 2008-12-15 [PMID: 19075116] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Williams CK, Segarra M, Sierra Mde L, Sainson RC, Tosato G, Harris AL Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res., 2008-03-15;68(6):1889-95. 2008-03-15 [PMID: 18339870] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Show All 45 Publications. Collapse Publications.

	Verified Customer 02/19/2015
Application:	IF
Species:	Mouse

Gene Symbol	CXCR4
Uniprot	P70658()