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CXCR4 Antibody (247506) [Phycoerythrin]

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Mouse thymocytes were stained with (A) Rat Anti-Mouse CXCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB21651P) or (B) Rat IgG2Bisotype control antibody (Catalog # IC013P) and Rat anti-Mouse CD8 alpha APC-conjugated Monoclonal Antibody (Catalog # FAB116A). View our protocol for Staining Membrane-associated Proteins.
Mouse thymocytes were stained with (A) Rat Anti-Mouse CXCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB21651P) or (B) Rat IgG2Bisotype control antibody (Catalog # IC013P) and Rat anti-Mouse CD8 alpha APC-conjugated ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow
Clone
247506
Clonality
Monoclonal
Host
Rat
Conjugate
Phycoerythrin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB21651U-100UG
Alexa Fluor 405
FAB21651V-100UG
Alexa Fluor 488
FAB21651G-100UG
Alexa Fluor 532
FAB21651X
Alexa Fluor 594
FAB21651T-100UG
Alexa Fluor 647
FAB21651R-100UG
Alexa Fluor 700
FAB21651N-100UG
Alexa Fluor 750
FAB21651S-100UG
Allophycocyanin
FAB21651A-100UG
Allophycocyanin
FAB21651A-025UG
Allophycocyanin/Cy7
FAB21651APCCY7
Biotin
FAB21651B
CoraFluor 1
FAB21651CL1
DyLight 350
FAB21651D
DyLight 405
FAB21651E
DyLight 488
FAB21651K
DyLight 550
FAB21651L
DyLight 594
FAB21651M
DyLight 650
FAB21651W
DyLight 680
FAB21651Y
DyLight 755
FAB21651Z
Fluorescein
FAB21651F-025
Fluorescein
FAB21651F-100
HRP
FAB21651H
Janelia Fluor 525
FAB21651JF525
Janelia Fluor 549
FAB21651I
Janelia Fluor 646
FAB21651J
Janelia Fluor 669
FAB21651JF669
PE/Atto594
FAB21651PEATT594
PE/Cy5.5
FAB21651PECY55
PE/Cy7
FAB21651PECY7
Phycoerythrin
FAB21651P-100
Unconjugated
MAB21651-100
mFluor Violet 450 SE
FAB21651MFV450
mFluor Violet 500 SE
FAB21651MFV500
mFluor Violet 610 SE
FAB21651MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB21651-100
Carrier Free
FAB21651T-100UG
Carrier Free
FAB21651A-100UG
Carrier Free
FAB21651V-100UG
Carrier Free
FAB21651G-100UG
Carrier Free
FAB21651N-100UG
Carrier Free
FAB21651R-100UG
Carrier Free
FAB21651S-100UG
Carrier Free
FAB21651U-100UG
Carrier Free
FAB21651F-025
Carrier Free
MAB21651-500
Carrier Free
MAB21651-SP
Carrier Free
MAB21651-100
Carrier Free
FAB21651P-100
Carrier Free
FAB21651F-100
Carrier Free
FAB21651A-025UG
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CXCR4 Antibody (247506) [Phycoerythrin] Summary

Immunogen
Y3 rat myeloid cell line transfected with mouse CXCR4
Met1-Ser359
Accession # P70658
Specificity
Detects mouse CXCR4 transfectants. Does not stain irrelevant transfectants.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
CXCR4
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB21651P in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR4 Antibody (247506) [Phycoerythrin]

  • CD184
  • chemokine (C-X-C motif) receptor 4
  • chemokine (C-X-C motif), receptor 4 (fusin)
  • C-X-C chemokine receptor type 4
  • CXCR4
  • CXC-R4
  • CXCR-4
  • D2S201E
  • D2S201ESDF-1 receptor
  • FB22
  • Fusin
  • HM89
  • HM89NPYRL
  • HSY3RR
  • LAP3
  • LAP-3
  • LCR1
  • LESTR
  • LESTRCD184 antigen
  • Leukocyte-derived seven transmembrane domain receptor
  • leukocyte-derived seven-transmembrane-domain receptor
  • lipopolysaccharide-associated protein 3
  • neuropeptide Y receptor Y3
  • NPY3R
  • NPY3RWHIM
  • NPYR
  • NPYRL
  • NPYY3R
  • pCXCR4
  • seven transmembrane helix receptor
  • seven-transmembrane-segment receptor, spleen
  • Stromal cell-derived factor 1 receptor
  • WHIMS

Background

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells. While primarily a membrane protein, CXCR4 undergoes trafficking and internalization in response to stimulation with phorbol esters and ligand (1). Cytoplasmic and nuclear localization of CXCR4 has been observed in colorectal and renal carcinomas (2,3) and it has been used as the basis of prognosis and metastatic state (3,4,5).
  1. Orsini, M.J. et al. (1999) J. Biol. Chem. 274:31076.
  2. Zagzag, D. et al. (2005) Cancer Res. 65:6178.
  3. Speetjens, F.M. et al. (2009) Cancer Microenvironment 2:1.
  4. Wang, L. et al. (2009) Oncology Reports 22:1333.
  5. Amara, S. et al. (2015) Cancer Biomark. 15:869.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CXCR4 Antibody
(247506) [Phycoerythr
FAB21651P
CXCR4 Antibody (247506) [Phycoerythrin]
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Applications: Flow

Publications for CXCR4 Antibody (FAB21651P)(9)

We have publications tested in 2 confirmed species: Mouse, Transgenic Mouse.

We have publications tested in 1 application: Flow Cytometry.


Filter By Application
Flow Cytometry
(9)
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Mouse
(9)
Transgenic Mouse
(1)
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Showing Publications 1 - 9 of 9.
Publications using FAB21651P Applications Species
D Canjuga, H Steinle, J Mayer, AK Uhde, G Klein, HP Wendel, C Schlensak, M Avci-Adali Homing of mRNA-Modified Endothelial Progenitor Cells to Inflamed Endothelium Pharmaceutics, 2022-06-02;14(6):. 2022-06-02 [PMID: 35745767] (Flow Cytometry, Mouse) Flow Cytometry Mouse
JT Cohen, M Danise, JT Machan, R Zhao, CT Lefort Murine Myeloid Progenitors Attenuate Immune Dysfunction Induced by Hemorrhagic Shock Stem Cell Reports, 2021-01-21;16(2):324-336. 2021-01-21 [PMID: 33482101] (Flow Cytometry, Mouse) Flow Cytometry Mouse
A Filippi, A Constantin, N Alexandru, G Voicu, CA Constantin, D Rebleanu, M Fenyo, D Simionescu, A Simionescu, I Manduteanu, A Georgescu Integrins alpha4beta1 and alphaVbeta3 are Reduced in Endothelial Progenitor Cells from Diabetic Dyslipidemic Mice and May Represent New Targets for Therapy in Aortic Valve Disease Cell Transplant, 2020-01-01;29(0):9636897209462. 2020-01-01 [PMID: 32841051] (Flow Cytometry, Mouse, Transgenic Mouse) Flow Cytometry Mouse, Transgenic Mouse
Badr G, Sayed A, Abdel-Maksoud M, Mohamed A, El-Amir A, Abdel-Ghaffar F, Al-Quraishy S, Mahmoud M Infection of Female BWF1 Lupus Mice with Malaria Parasite Attenuates B Cell Autoreactivity by Modulating the CXCL12/CXCR4 Axis and Its Downstream Signals PI3K/AKT, NFkappaB and ERK. PLoS ONE, 2015-04-24;10(4):e0125340. 2015-04-24 [PMID: 25909640] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Zheng , Jiao, Yang , Min, Shao , Jianghua, Miao , Yanju, Han , Jiahuai, Du , Jie Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis. Mol Cancer, 2013-11-18;12(1):141. 2013-11-18 [PMID: 24245985] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Tarrant , Teresa K, Billard , Matthew, Timoshchenko , Roman G, McGinnis , Marcus W, Serafin , D Stephe, Foreman , Oded, Esserman , Denise A, Chao , Nelson J, Lento , William, Lee , David M, Patel , Dhavalku, Siderovski , David P G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. J Leukoc Biol, 2013-08-09;94(6):1243-51. 2013-08-09 [PMID: 23935208] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Salvucci O, Jiang K, Gasperini P MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1. Haematologica, 2012-01-22;97(6):818-26. 2012-01-22 [PMID: 22271895] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J. Cell Biol., 2008-12-15;183(6):1145-57. 2008-12-15 [PMID: 19075116] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice. Fertil. Steril., 2008-04-02;91(6):2687-96. 2008-04-02 [PMID: 18384776] (Flow Cytometry, Mouse) Flow Cytometry Mouse

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for CXCR4 Antibody (FAB21651P). (Showing 1 - 1 of 1 FAQs).

  1. Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.
    • CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

Secondary Antibodies

 

Isotype Controls

Additional CXCR4 Products

Blogs on CXCR4.

Check out the latest blog posts on CXCR4.
Stemness is responsible for onset and metastasis of colorectal cancer
By Jamshed Arslan, Pharm. D., PhD. Colorectal cancer stem cells are a rare subpopulation of colorectal cancer cells that can self-renew and initiate and sustain tumor growth when transplanted into an animal host.1,2 C...  Read full blog post.
LAMP2: Protector of the lysosome
LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...  Read full blog post.
CXCR4 Studies on Neural and Stem Cells
The CXCR4 (C-X-C chemokine receptor type 4) protein is one member of the G-protein coupled receptor (GPCR1) family. As a multipass membrane protein that is found in several tissues, it is the receptor for the C-X-C chemokine CXCL12/SDF-1. The CXCR4 li...  Read full blog post.
Understanding CXCR4 and SDF1
CXCR4 (C-X-C chemokine receptor type 4) is a member of the G-protein coupled receptor (GPCR1) family. It is expressed as a multipass membrane protein in several tissues where it acts as the receptor for the C-X-C chemokine CXCL12/SDF-1. This ligand in...  Read full blog post.
Read our latest blog and use the new citation tool on bio-techne.com

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Bioinformatics

Gene Symbol CXCR4
Uniprot