Which is your best CXCR4 for immunohistochemistry in paraffin tissues? I would like to detect it in paraffin embedded tissues from human breast cancer samples.

Name: CXCR4 Antibody (12G5) [Phycoerythrin]
Brand: Novus Biologicals
SKU: FAB170P
Rating: 5 (2 reviews)

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CXCR4 antibody (NB100-74396) is our best selling product among all the CXCR4 antibodies and it has been validated for IHC-P in human cervical carcinoma tissue sections. NB100-74396 has been cited in at least 7 research publications. Additionally, here is a list of all of our CXCR4 antibodies that has been verified in IHC-P in human samples.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Flow
Clone	12G5
Clonality	Monoclonal
Host	Mouse
Conjugate	Phycoerythrin

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB170U-100UG

Alexa Fluor 405 FAB170V-100UG

Alexa Fluor 488 FAB170G-025

Alexa Fluor 488 FAB170G-100

Alexa Fluor 532 FAB170X

Alexa Fluor 594 FAB170T-100UG

Alexa Fluor 647 FAB170R-100UG

Alexa Fluor 750 FAB170S-100UG

Allophycocyanin FAB170A-025

Allophycocyanin FAB170A-100

Allophycocyanin/Cy7 FAB170APCCY7

Biotin FAB170B

DyLight 350 FAB170D

DyLight 405 FAB170E

DyLight 488 FAB170K

DyLight 550 FAB170L

DyLight 594 FAB170M

DyLight 650 FAB170W

DyLight 680 FAB170Y

DyLight 755 FAB170Z

Fluorescein FAB170F-025

Fluorescein FAB170F-100

HRP FAB170H

Janelia Fluor 549 FAB170I

Janelia Fluor 646 FAB170J

PE/Atto594 FAB170PEATT594

PE/Cy5.5 FAB170PECY55

PE/Cy7 FAB170PECY7

Phycoerythrin FAB170P-100

Unconjugated MAB170

Catalog# & Formulation	Size	Price
Standard Formulation MAB170

Carrier Free FAB170G-025

Carrier Free FAB170S-100UG

Carrier Free FAB170T-100UG

Carrier Free FAB170U-100UG

Carrier Free FAB170V-100UG

Carrier Free MAB170-SP

Carrier Free MAB170

Carrier Free FAB170G-100

Carrier Free FAB170F-025

Carrier Free FAB170B

Carrier Free FAB170A-100

Carrier Free FAB170A-025

Carrier Free FAB170P-100

Carrier Free FAB170F-100

Carrier Free FAB170R-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB170U-100UG
Alexa Fluor 405	FAB170V-100UG
Alexa Fluor 488	FAB170G-025
Alexa Fluor 488	FAB170G-100
Alexa Fluor 532	FAB170X
Alexa Fluor 594	FAB170T-100UG
Alexa Fluor 647	FAB170R-100UG
Alexa Fluor 750	FAB170S-100UG
Allophycocyanin	FAB170A-025
Allophycocyanin	FAB170A-100
Allophycocyanin/Cy7	FAB170APCCY7
Biotin	FAB170B
DyLight 350	FAB170D
DyLight 405	FAB170E
DyLight 488	FAB170K
DyLight 550	FAB170L
DyLight 594	FAB170M
DyLight 650	FAB170W
DyLight 680	FAB170Y
DyLight 755	FAB170Z
Fluorescein	FAB170F-025
Fluorescein	FAB170F-100
HRP	FAB170H
Janelia Fluor 549	FAB170I
Janelia Fluor 646	FAB170J
PE/Atto594	FAB170PEATT594
PE/Cy5.5	FAB170PECY55
PE/Cy7	FAB170PECY7
Phycoerythrin	FAB170P-100
Unconjugated	MAB170

CXCR4 Antibody (12G5) [Phycoerythrin]

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Publications for CXCR4 Antibody (FAB170P)(40)

Reviews for CXCR4 Antibody (FAB170P) (2) 52

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Immunogen	CP-MAC-infected SUP-T1 human T cell lymphoblastic lymphoma line Accession # P61073
Specificity	Detects human CXCR4.
Source	N/A
Isotype	IgG2a
Clonality	Monoclonal
Host	Mouse
Gene	CXCR4
Purity Statement	Protein A or G purified from ascites
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer	Supplied in a saline solution containing BSA and Sodium Azide.
Preservative	Sodium Azide

Publications using FAB170P	Applications	Species
García-Cuesta, EM;Martínez, P;Selvaraju, K;Ulltjärn, G;Gómez Pozo, AM;D'Agostino, G;Gardeta, S;Quijada-Freire, A;Blanco Gabella, P;Roca, C;Hoyo, DD;Jiménez-Saiz, R;García-Rubia, A;Soler Palacios, B;Lucas, P;Ayala-Bueno, R;Santander Acerete, N;Carrasco, Y;Oscar Sorzano, C;Martinez, A;Campillo, NE;Jensen, LD;Rodriguez Frade, JM;Santiago, C;Mellado, M; Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain eLife 2024-09-09 [PMID: 39248648] (Flow Cytometry, Human)	Flow Cytometry	Human
Portella, L;Bertolini, G;Guardascione, G;Di Febbraro, DG;Ieranò, C;D'Alterio, C;Rea, G;Napolitano, M;Santagata, S;Trotta, AM;Camerlingo, R;Scarpa, E;Cecere, SC;Ottaiano, A;Palumbo, G;Morabito, A;Somma, T;De Rosa, G;Mayol, L;Pacelli, R;Pignata, S;Scala, S; CXCL12-loaded-hydrogel (CLG): A new device for metastatic circulating tumor cells (CTCs) capturing and characterization Heliyon 2024-08-15 [PMID: 39170328] (Flow Cytometry, Human)	Flow Cytometry	Human
Trotta, AM;Tomassi, S;Di Maiolo, G;Ieranò, C;Vetrei, C;D'Alterio, C;Merlino, F;Messere, A;D'Aniello, A;Del Bene, A;Mazzarella, V;Roggia, M;Natale, B;Cutolo, R;Campagna, E;Mottola, S;Russo, R;Chambery, A;Benedetti, R;Altucci, L;Cosconati, S;Scala, S;Di Maro, S; Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites European journal of medicinal chemistry 2024-07-14 [PMID: 39053189] (Flow Cytometry, Human)	Flow Cytometry	Human
Garrido-Trigo, A;Corraliza, AM;Veny, M;Dotti, I;Melón-Ardanaz, E;Rill, A;Crowell, HL;Corbí, Á;Gudiño, V;Esteller, M;Álvarez-Teubel, I;Aguilar, D;Masamunt, MC;Killingbeck, E;Kim, Y;Leon, M;Visvanathan, S;Marchese, D;Caratù, G;Martin-Cardona, A;Esteve, M;Panés, J;Ricart, E;Mereu, E;Heyn, H;Salas, A; Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease Nature communications 2023-07-26 [PMID: 37495570] (Flow Cytometry, Human)	Flow Cytometry	Human
V Veschi, A Turdo, C Modica, F Verona, S Di Franco, M Gaggianesi, E Tirrò, S Di Bella, ML Iacono, VD Pantina, G Porcelli, LR Mangiapane, P Bianca, A Rizzo, E Sciacca, I Pillitteri, V Vella, A Belfiore, MR Bongiorno, G Pistone, L Memeo, L Colarossi, D Giuffrida, C Colarossi, P Vigneri, M Todaro, G Stassi Recapitulating thyroid cancer histotypes through engineering embryonic stem cells Nature Communications, 2023-03-11;14(1):1351. 3/11/2023 [PMID: 36906579]
JS Paradis, X Feng, B Murat, RE Jefferson, B Sokrat, M Szpakowska, M Hogue, ND Bergkamp, FM Heydenreic, MJ Smit, A Chevigné, M Bouvier, P Barth Computationally designed GPCR quaternary structures bias signaling pathway activation Nature Communications, 2022-11-11;13(1):6826. 2022-11-11 [PMID: 36369272] (Flow Cytometry, Human)	Flow Cytometry	Human
Alexandra Bona, Michael Seifert, Roland Thünauer, Kyra Zodel, Ian J. Frew, Winfried Römer et al. MARVEL domain containing CMTM4 affects CXCR4 trafficking Molecular Biology of the Cell 11/1/2022 [PMID: 36044337]
M Lee-Theile, JR Hadhoud, G Volante, DD Fadini, J Eichhorn, U Rolle, HC Fiegel Co-Expression of CD34, CD90, OV-6 and Cell-Surface Vimentin Defines Cancer Stem Cells of Hepatoblastoma, Which Are Affected by Hsp90 Inhibitor 17-AAG Cells, 2021-09-29;10(10):. 2021-09-29 [PMID: 34685577] (Flow Cytometry, Human)	Flow Cytometry	Human
Justyna Magdalena Kowal, Sören Möller, Dalia Ali, Florence Figeac, Torben Barington, Hagen Schmal et al. Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells Stem Cell Research & Therapy 12/1/2021 [PMID: 33941262]
Anne-Claire Lagrée, Fabienne Fasani, Clotilde Rouxel, Marine Pivet, Marie Pourcelot, Aurore Fablet et al. Bovine Organospecific Microvascular Endothelial Cell Lines as New and Relevant In Vitro Models to Study Viral Infections International Journal of Molecular Sciences 7/24/2020 [PMID: 32722052]
Sandra L. Leibel, Rachael N. McVicar, Alicia M. Winquist, Walter D. Niles, Evan Y. Snyder Generation of Complete Multi−Cell Type Lung Organoids From Human Embryonic and Patient‐Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation Current Protocols in Stem Cell Biology 9/1/2020 [PMID: 32640120]
S Tan, W Li, Z Li, Y Li, J Luo, L Yu, J Yang, M Qiu, H Cheng, W Xu, S Jiang, L Lu, S Liu, W Ma A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor Viruses, 2019-09-18;11(9):. 2019-09-18 [PMID: 31540474] (Flow Cytometry, Human)	Flow Cytometry	Human
I Del Molino, GC Wilkins, A Meeson, S Ali, JA Kirby Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12 Int J Mol Sci, 2018-11-14;19(11):. 2018-11-14 [PMID: 30441765] (Flow Cytometry, Human)	Flow Cytometry	Human
P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon Precardiac organoids form two heart fields via Bmp/Wnt signaling Nat Commun, 2018-08-07;9(1):3140. 2018-08-07 [PMID: 30087351]
I Aversa, F Zolea, C Ieranò, S Bulotta, AM Trotta, MC Faniello, C De Marco, D Malanga, F Biamonte, G Viglietto, G Cuda, S Scala, F Costanzo Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis J. Exp. Clin. Cancer Res., 2017-08-03;36(1):104. 2017-08-03 [PMID: 28774348] (Flow Cytometry, Human)	Flow Cytometry	Human
Tingting Cheng, Kui Zhai, Yan Chang, Guidong Yao, Jiahuan He, Fang Wang et al. CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells Oncotarget 1/31/2017 [PMID: 27999196]
Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering PLoS ONE, 2016-11-30;11(11):e0167056. 2016-11-30 [PMID: 27902740] (Flow Cytometry, Human)	Flow Cytometry	Human
Marian Vincenzi, Susan Costantini, Stefania Scala, Diego Tesauro, Antonella Accardo, Marilisa Leone et al. Conformational Ensembles Explored Dynamically from Disordered Peptides Targeting Chemokine Receptor CXCR4 International Journal of Molecular Sciences 5/28/2015 [PMID: 26030674]
Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, Cui W PI3K/mTORC2 regulates TGF-beta/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun, 2015-05-22;6(0):7212. 2015-05-22 [PMID: 25998442] (Flow Cytometry, Human)	Flow Cytometry	Human
Panneerselvam J, Jin J, Shanker M, Lauderdale J, Bates J, Wang Q, Zhao Y, Archibald S, Hubin T, Ramesh R IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. PLoS ONE, 2015-03-16;10(3):e0122439. 2015-03-16 [PMID: 25775124] (Flow Cytometry, Human)	Flow Cytometry	Human
Shankar V, Hori H, Kihira K, Lei Q, Toyoda H, Iwamoto S, Komada Y Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines. PLoS ONE, 2015-03-16;10(3):e0120069. 2015-03-16 [PMID: 25774696] (Flow Cytometry, Human)	Flow Cytometry	Human
Patrick M. Perrigue, Michael E. Silva, Charles D. Warden, Nathan L. Feng, Michael A. Reid, Daniel J. Mota et al. The Histone Demethylase Jumonji Coordinates Cellular Senescence Including Secretion of Neural Stem Cell–Attracting Cytokines Molecular Cancer Research 4/1/2015 [PMID: 25652587]
Peled A, Abraham M, Avivi I, Rowe J, Beider K, Wald H, Tiomkin L, Ribakovsky L, Riback Y, Ramati Y, Aviel S, Galun E, Shaw H, Eizenberg O, Hardan I, Shimoni A, Nagler A The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma. Clin Cancer Res, 2013-11-18;20(2):469-79. 2013-11-18 [PMID: 24246358] (Flow Cytometry, Human)	Flow Cytometry	Human
Luigi Portella, Rosamaria Vitale, Stefania De Luca, Crescenzo D’Alterio, Caterina Ieranò, Maria Napolitano et al. Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases PLoS ONE 9/13/2013 [PMID: 24058588]
Goldman O, Han S, Sourisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton D, Bissig K, Kalir T, Jacobs A, Evans T, Evans M, Gouon-Evans V KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell, 2013-06-06;12(6):748-60. 2013-06-06 [PMID: 23746980] (Flow Cytometry, Human)	Flow Cytometry	Human
Cerdeira A, Rajakumar A, Royle C, Lo A, Husain Z, Thadhani R, Sukhatme V, Karumanchi S, Kopcow H Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors. J Immunol, 2013-03-13;190(8):3939-48. 2013-03-13 [PMID: 23487420] (Flow Cytometry, Human)	Flow Cytometry	Human
CXCR4 positive and angiogenic monocytes in myocardial infarction. Thromb Haemost, 2012-12-06;109(2):255-62. 2012-12-06 [PMID: 23223950] (Flow Cytometry, Human)	Flow Cytometry	Human
Bone HK, Nelson AS, Goldring CE, Tosh D, Welham MJ A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J. Cell. Sci., 2011-05-24;124(0):1992-2000. 2011-05-24 [PMID: 21610099] (Flow Cytometry, Human)	Flow Cytometry	Human
Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, Drayson MT, Lip GY Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. J. Thromb. Haemost., 2011-05-01;9(5):1056-66. 2011-05-01 [PMID: 21342432] (Flow Cytometry, Human)	Flow Cytometry	Human
Patricia A Cronin, Jiang H Wang, H Paul Redmond Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4 BMC Cancer 12/1/2010 [PMID: 20492653]
Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J. Immunol., 2010-02-17;184(6):2886-98. 2010-02-17 [PMID: 20164417] (Flow Cytometry, Human)	Flow Cytometry	Human
Levings PP, McGarry SV, Currie TP, Nickerson DM, McClellan S, Ghivizzani SC, Steindler DA, Gibbs CP Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res., 2009-07-07;69(14):5648-55. 2009-07-07 [PMID: 19584295] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Kroeze KL, Jurgens WJ, Doulabi BZ, van Milligen FJ, Scheper RJ, Gibbs S Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES. J. Invest. Dermatol., 2009-01-01;129(6):1569-81. 2009-01-01 [PMID: 19122644] (Flow Cytometry, Human)	Flow Cytometry	Human
Bucay N, Yebra M, Cirulli V, Afrikanova I, Kaido T, Hayek A, Montgomery AM A Novel Approach for the Derivation of Putative Primordial Germ Cells and Sertoli Cells from Human Embryonic Stem Cells. Stem Cells, 2009-01-01;0(0):. 2009-01-01 [PMID: 18845765] (Flow Cytometry, ICC, Human)	Flow Cytometry, ICC	Human
Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation. J. Neuroimmunol., 2008-06-09;199(1):35-45. 2008-06-09 [PMID: 18538864] (Flow Cytometry, Human)	Flow Cytometry	Human
Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. Cardiovasc. Res., 2006-05-09;71(3):455-65. 2006-05-09 [PMID: 16769043] (Flow Cytometry, Rabbit)	Flow Cytometry	Rabbit
Muller A, Sonkoly E, Eulert C, Gerber PA, Kubitza R, Schirlau K, Franken-Kunkel P, Poremba C, Snyderman C, Klotz LO, Ruzicka T, Bier H, Zlotnik A, Whiteside TL, Homey B, Hoffmann TK Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Int. J. Cancer, 2006-05-01;118(9):2147-57. 2006-05-01 [PMID: 16331601] (Flow Cytometry, Human)	Flow Cytometry	Human
Singh S, Singh UP, Grizzle WE, Lillard JW CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab. Invest., 2004-12-01;84(12):1666-76. 2004-12-01 [PMID: 15467730] (Flow Cytometry, Human)	Flow Cytometry	Human
Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood, 2004-09-28;105(3):931-9. 2004-09-28 [PMID: 15454484] (Flow Cytometry, Human)	Flow Cytometry	Human
Liu LY, Jarjour NN, Busse WW, Kelly EA Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge. J. Allergy Clin. Immunol., 2003-09-01;112(3):556-62. 2003-09-01 [PMID: 13679815] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 40 Publications. Collapse Publications.

	Verified Customer 01/21/2015
Application:	Flow
Species:	Human

	Verified Customer 01/21/2015
Application:	Flow
Species:	Human

Gene Symbol	CXCR4
Uniprot	P61073()