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CXCL13/BLC/BCA-1 Antibody (53602) [Alexa Fluor® 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
53602
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
IC8012U-100UG
Alexa Fluor 350
FAB8012U
Alexa Fluor 405
FAB8012V
Alexa Fluor 405
IC8012V-100UG
Alexa Fluor 488
FAB8012G
Alexa Fluor 532
FAB8012X
Alexa Fluor 594
FAB8012T
Alexa Fluor 594
IC8012T-100UG
Alexa Fluor 647
IC8012R-100UG
Alexa Fluor 647
FAB8012R
Alexa Fluor 700
IC8012N-100UG
Alexa Fluor 700
FAB8012N
Alexa Fluor 750
IC8012S-100UG
Alexa Fluor 750
FAB8012S
Allophycocyanin
FAB8012A
Biotin
FAB8012B
DyLight 350
FAB8012D
DyLight 405
FAB8012E
DyLight 488
FAB8012K
DyLight 550
FAB8012L
DyLight 594
FAB8012M
DyLight 650
FAB8012W
DyLight 680
FAB8012Y
DyLight 755
FAB8012Z
FITC
FAB8012F
HRP
FAB8012H
Janelia Fluor 549
FAB8012I
Janelia Fluor 646
FAB8012J
PE
FAB8012P
PerCP
FAB8012C
Phycoerythrin
IC8012P-100
Unconjugated
MAB8012-100
mFluor Violet 450 SE
FAB8012MFV450
mFluor Violet 500 SE
FAB8012MFV500
mFluor Violet 610 SE
FAB8012MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB8012-100
Carrier Free
IC8012N-100UG
Carrier Free
IC8012S-100UG
Carrier Free
IC8012T-100UG
Carrier Free
IC8012V-100UG
Carrier Free
IC8012U-100UG
Carrier Free
IC8012R-100UG
Carrier Free
IC8012P-100
Carrier Free
MAB8012-100
Carrier Free
MAB8012-SP
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CXCL13/BLC/BCA-1 Antibody (53602) [Alexa Fluor® 488] Summary

Immunogen
E. coli-derived recombinant human CXCL13/BLC/BCA-1
Val23-Arg94
Accession # O43927
Specificity
Detects human CXCL13/BLC/BCA-1 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCL13/BLC/BCA-1 Antibody (53602) [Alexa Fluor® 488]

  • ANGIE
  • ANGIE2
  • B cell-attracting chemokine 1
  • B lymphocyte chemoattractant
  • BCA1
  • BCA-1
  • BCA1B-cell chemoattractant
  • BCA-1CXC chemokine BLC
  • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
  • BLC
  • BLCSmall-inducible cytokine B13
  • BLR1L
  • B-lymphocyte chemoattractant
  • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
  • chemokine (C-X-C motif) ligand 13
  • C-X-C motif chemokine 13
  • CXCL13
  • SCYB13
  • SCYB13B-cell-attracting chemokine 1
  • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)

Background

CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. BCA-1 cDNA encodes a protein of 109 amino acid residues with a leader sequence of 22 residues. Mature human BCA-1 shares 64% amino acid sequence similarity with the mouse protein and 23-34% amino acid sequence identity with other known CXC chemokines. Recombinant or chemically synthesized BCA-1 is a potent chemoattractant for B lymphocytes but not T lymphocytes, monocytes or neutrophils. BLR1, a G protein-coupled receptor originally isolated from Burkitt’s lymphoma cells, has now been shown to be the specific receptor for BCA-1. Among cells of the hematopoietic lineages, the expression of BLR1, now designated CXCR5, is restricted to B lymphocytes and a subpopulation of T helper memory cells. Mice lacking BLR1 have been shown to lack inguinal lymph nodes. These mice were also found to have impaired development of Peyer’s patches and defective formation of primary follicles and germinal centers in the spleen as a result of the inability of B lymphocytes to migrate into B cell areas.

  1. Gunn, M.D. et al. (1998) Nature, 391:799.
  2. Legler, D.F. et al. (1998) J. Exp. Med. 187:655.
  3. Forster, R. et al. (1996) Cell 87:1037.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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