CXCL1/GRO alpha/KC/CINC-1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

KC, a member of the alpha (CXC) chemokine subfamily, was initially identified as an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor. KC cDNA encodes a 96 amino acid (aa) residue precursor protein with a predicted secretory signal peptide that is removed to yield the mature protein. The protein sequence of mouse KC shows approximately 63% identity to that of mouse MIP-2. KC is also approximately 60% identical to the human GROs. It has been suggested that mouse KC and MIP-2 are the orthologs of the human GROs and rat CINCs. In addition to mouse fibroblasts, KC is expressed in macrophages and endothelial cells. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease. Many chemokines are substrates for selective proteolysis at the amino-terminus by various proteases including dipeptidyl peptidase IV or matrix metalloproteases, resulting in truncated chemokine isoforms with different (both enhanced or reduced) bioactivities. The naturally occurring 68 aa N-terminal truncated isoform of mouse KC is reported to be a more potent synergistic growth stimulants for CFU-GM.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 8 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, In Vivo, Neutralization, Western Blot.

Showing Publications 1 - 10 of 32. Show All 32 Publications. Collapse Publications.

Publications using AF-453-NA	Applications	Species
YS Hwang, HJ Cho, ES Park, J Lim, HR Yoon, JT Kim, SR Yoon, H Jung, YK Choe, YH Kim, CH Lee, YT Kwon, BY Kim, HG Lee KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages Cells, 2022-12-16;11(24):. 2022-12-16 [PMID: 36552865] (Neutralization, Mouse)	Neutralization	Mouse
R Joulia, IM Guerrero-F, T Girbl, JA Coates, M Stein, L Vázquez-Ma, E Lynam, J Whiteford, M Schnoor, D Voehringer, A Roers, S Nourshargh, MB Voisin Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A Nature Communications, 2022-11-17;13(1):7029. 2022-11-17 [PMID: 36396641] (Flow Cytometry, IHC, Mouse)	Flow Cytometry, IHC	Mouse
T Komori, Y Morikawa Essential roles of the cytokine oncostatin M in crosstalk between muscle fibers and immune cells in skeletal muscle after aerobic exercise The Journal of Biological Chemistry, 2022-11-09;0(0):102686. 2022-11-09 [PMID: 36370846] (Western Blot, Mouse)	Western Blot	Mouse
X Dong, Q Zhang, X Yu, D Wang, J Ma, J Ma, SH Shi Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex Nature Neuroscience, 2022-06-20;0(0):. 2022-06-20 [PMID: 35726058] (IHC, Mouse)	IHC	Mouse
Hinami Asano, Sanae Hasegawa-Ishii, Ken Arae, Aki Obara, Geoffroy Laumet, Robert Dantzer et al. Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation Journal of Neuroimmunology 2022-07-01 [PMID: 35661951]
Anna Barkaway, Loïc Rolas, Régis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods et al. Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage Immunity 2021-07-13 [PMID: 34033752]
A Shimada, S Hasegawa-I Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice Toxicology reports, 2021-03-10;8(0):520-528. 2021-03-10 [PMID: 33747797] (IHC, Mouse)	IHC	Mouse
Y Makino, K Fujikawa, M Matsuki-Fu, S Inoue, M Nakamura Role of Innate Inflammation in the Regulation of Tissue Remodeling during Tooth Eruption Dentistry journal, 2021-01-12;9(1):. 2021-01-12 [PMID: 33445432] (IHC, Mouse)	IHC	Mouse
YY Wang, HD Chen, S Lo, YK Chen, YC Huang, SC Hu, YC Hsieh, AC Hung, MF Hou, SF Yuan Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages Cancers, 2020-11-26;12(12):. 2020-11-26 [PMID: 33256011] (In Vivo, Mouse)	In Vivo	Mouse
WL Hwang, HY Lan, WC Cheng, SC Huang, MH Yang Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer J Hematol Oncol, 2019-01-25;12(1):10. 1/25/2019 [PMID: 30683126]
Tamara Girbl, Tchern Lenn, Lorena Perez, Loïc Rolas, Anna Barkaway, Aude Thiriot et al. Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis Immunity 2018-12-18 [PMID: 30446388]
JS Stoolman, PC Duncker, AK Huber, DA Giles, JM Washnock-S, AM Soulika, BM Segal An IFN?/CXCL2 regulatory pathway determines lesion localization during EAE J Neuroinflammation, 2018-07-16;15(1):208. 2018-07-16 [PMID: 30012158] (IHC, Mouse)	IHC	Mouse
Monoranjan Boro, Kithiganahalli Narayanaswamy Balaji CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein–Coupled Receptor CXCR2 The Journal of Immunology 2017-09-01 [PMID: 28739876]
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses Sci Rep, 2016-11-24;6(0):37695. 2016-11-24 [PMID: 27883091] (Neutralization, Mouse)	Neutralization	Mouse
Marro B, Grist J, Lane T Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination. J Immunol, 2016-01-15;196(4):1855-64. 2016-01-15 [PMID: 26773148] (IHC, Mouse)	IHC	Mouse
Edel Hennessy, Éadaoin W. Griffin, Colm Cunningham Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1 beta and TNF-alpha The Journal of Neuroscience 2015-06-03 [PMID: 26041910]
Wang H, Hong L, Huang J, Jiang Q, Tao R, Tan C, Lu N, Wang C, Ahmed M, Lu Y, Liu Z, Shi W, Lai E, Wilcox C, Han F P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res, 2015-05-22;25(6):674-90. 2015-05-22 [PMID: 25998681] (IHC, Neutralization, Mouse)	IHC, Neutralization	Mouse
Mizugishi K, Inoue T, Hatayama H, Bielawski J, Pierce J, Sato Y, Takaori-Kondo A, Konishi I, Yamashita K Sphingolipid pathway regulates innate immune responses at the fetomaternal interface during pregnancy. J Biol Chem, 2014-12-11;290(4):2053-68. 2014-12-11 [PMID: 25505239] (IHC, Mouse)	IHC	Mouse
Jablonska J, Wu C, Andzinski L, Leschner S, Weiss S CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-beta. Int J Cancer, 2013-10-31;134(6):1346-58. 2013-10-31 [PMID: 24154944] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Habibzay , M, Saldana , J I, Goulding , J, Lloyd , C M, Hussell , T Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung. Mucosal Immunol, 2012-05-02;5(5):524-34. 2012-05-02 [PMID: 22549744] (IHC-P, Mouse)	IHC-P	Mouse
Li Z, Burns AR, Miller SB, Smith CW CCL20, gammadelta T cells, and IL-22 in corneal epithelial healing. FASEB J., 2011-04-25;25(8):2659-68. 2011-04-25 [PMID: 21518851] (Neutralization, Mouse)	Neutralization	Mouse
Summers SA, van der Veen BS, O'Sullivan KM Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int., 2010-09-15;78(12):1263-74. 2010-09-15 [PMID: 20844472] (IHC-P, Mouse)	IHC-P	Mouse
Tilahun AY, Theuer JE, Patel R Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation. Mol. Ther., 2010-04-06;18(6):1143-54. 2010-04-06 [PMID: 20372109] (Neutralization, Mouse)	Neutralization	Mouse
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D Comprehensive assessment of chemokine expression profiles by flow cytometry. J. Clin. Invest., 2010-02-08;120(3):907-23. 2010-02-08 [PMID: 20197626] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Zarbock A, Distasi MR, Smith E, Sanders JM, Kronke G, Harry BL, von Vietinghoff S, Buscher K, Nadler JL, Ley K Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI). J. Immunol., 2009-09-14;183(7):4715-22. 2009-09-14 [PMID: 19752233] (Neutralization, Mouse)	Neutralization	Mouse
Lemos HP, Grespan R, Vieira SM, Cunha TM, Verri WA, Fernandes KS, Souto FO, McInnes IB, Ferreira SH, Liew FY, Cunha FQ Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc. Natl. Acad. Sci. U.S.A., 2009-03-16;106(14):5954-9. 2009-03-16 [PMID: 19289819] (Neutralization, Mouse)	Neutralization	Mouse
Omari KM, Lutz SE, Santambrogio L, Lira SA, Raine CS Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. Am. J. Pathol., 2008-12-18;174(1):164-76. 2008-12-18 [PMID: 19095949] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Wu K, Katiyar S, Li A, Liu M, Ju X, Popov VM, Jiao X, Lisanti MP, Casola A, Pestell RG Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8. Proc. Natl. Acad. Sci. U.S.A., 2008-05-08;105(19):6924-9. 2008-05-08 [PMID: 18467491] (Neutralization, Mouse)	Neutralization	Mouse
Riou S, Mees B, Esposito B, Merval R, Vilar J, Stengel D, Ninio E, van Haperen R, de Crom R, Tedgui A, Lehoux S High pressure promotes monocyte adhesion to the vascular wall. Circ. Res., 2007-03-29;100(8):1226-33. 2007-03-29 [PMID: 17395876] (IHC, Mouse)	IHC	Mouse
Wislez M, Fujimoto N, Izzo JG, Hanna AE, Cody DD, Langley RR, Tang H, Burdick MD, Sato M, Minna JD, Mao L, Wistuba I, Strieter RM, Kurie JM High expression of ligands for chemokine receptor CXCR2 in alveolar epithelial neoplasia induced by oncogenic kras. Cancer Res., 2006-04-15;66(8):4198-207. 2006-04-15 [PMID: 16618742] (Western Blot, Mouse)	Western Blot	Mouse
Barksby HE, Hui W, Wappler I, Peters HH, Milner JM, Richards CD, Cawston TE, Rowan AD Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair. Arthritis Rheum., 2006-02-01;54(2):540-50. 2006-02-01 [PMID: 16447230] (IHC-P, Mouse)	IHC-P	Mouse
Huo Y, Weber C, Forlow SB, Sperandio M, Thatte J, Mack M, Jung S, Littman DR, Ley K The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium. J. Clin. Invest., 2001-11-01;108(9):1307-14. 2001-11-01 [PMID: 11696575] (ICC, IHC-P, Mouse)	ICC, IHC-P	Mouse
Show All 32 Publications. Collapse Publications.

Array AF-453-NA

• CXCL1/GRO alpha/KC/CINC-1 Antibodies
• CXCL1/GRO alpha/KC/CINC-1 ELISA Kit
• CXCL1/GRO alpha/KC/CINC-1 Proteins
• CXCL1/GRO alpha/KC/CINC-1 Proteins and Enzymes
• CXCL1/GRO alpha/KC/CINC-1 ELISAs