CUGBP1/CELF1 Antibody (3B1)

CUGBP1 (CUG-binding protein 1) is a member of CELF (CUG-BP- and ETR-3-like factors) family of RNA-binding proteins that binds to a variety of mRNA cis-elements including UG-rich elements, GC-rich elements, GU-rich elements and AREs, and has been implicated in the regulation of mRNA alternative splicing as well as the control of mRNA translation and stability. CUGBP1 is ubiquitously expressed with localization in nucleus and cytoplasm as a component of an EIF2 complex which contains CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. CUGBP1 also associates with polysomes and interacts with HNRNPH1 and PARN. CUGBP1 was originally discovered as a protein which interacts with RNA CUG repeats that are expanded in patients with DM1 (myotonic dystrophy), which binds to 3'-untranslated region of the dystrophin myotonia protein kinase (DMPK) gene. However, CUGBP1 was later shown as multifunctional protein regulating many posttranscriptional processes including alternative splicing, deadenylation, mRNA decay, and translation. It has been involved in the processes of development (embryonic and cardiac), differentiation (skeletal muscle and adipose tissue), germ cell formation, tumorigenesis (breast cancer, leukemia etc) and deterioration of certain tumors as well.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Primate.

We have publications tested in 7 applications: EMSA, ICC/IF, IF/IHC, IHC-Fr, IHC-P, IP, WB.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB200-316	Applications	Species
Markmiller S, Sathe S, Server KL et al. Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress Cell reports 2021-09-07 [PMID: 34496257]
de Haro M, Al-Ramahi I, Jones KR et al. Smaug/SAMD4A Restores Translational Activity of CUGBP1 and Suppresses CUG-Induced Myopathy. PLoS Genet 2013-04-01 [PMID: 23637619] (IP, WB, ICC/IF, Primate, Human)	IP, WB, ICC/IF	Primate, Human
Xiao Q, Ford AL, Xu J et al. Bcl-x Pre-mRNA Splicing Regulates Brain Injury after Neonatal Hypoxia-Ischemia J Neurosci 2012-09-26 [PMID: 23015448] (IF/IHC, ICC/IF, WB, EMSA, Mouse, Rat)	IF/IHC, ICC/IF, WB, EMSA	Mouse, Rat
Ward AJ, Rimer M, Killian JM, Dowling JJ, Cooper TA. CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Hum Mol Genet;19(18):3614-22. 2010-09-15 [PMID: 20603324]
Hashem V, Galloway JN, Mori M, Willemsen R, Oostra BA, Paylor R, Nelson DL. Ectopic expression of CGG containing mRNA is neurotoxic in mammals. Hum Mol Genet;18(13):2443-51. 2009-07-01 [PMID: 19377084] (IHC-P, Mouse)	IHC-P	Mouse
Orengo JP, Chambon P, Metzger D, Mosier DR, Snipes GJ, Cooper TA. Expanded CTG repeats within the DMPK 3' UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy. Proc Natl Acad Sci U S A;105(7):2646-51. 2008-02-19 [PMID: 18272483]
Kress, C et al. Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. Mol Cell Biol;27(3):1146-57. 2007-02-01 [PMID: 17130239] (WB, Mouse)	WB	Mouse
Lin X, Miller JW, Mankodi A, Kanadia RN, Yuan Y, Moxley RT, Swanson MS, Thornton CA. Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy. Hum Mol Genet;15(13):2087-97. 2006-07-01 [PMID: 16717059] (WB, ICC/IF, Human, Mouse)	WB, ICC/IF	Human, Mouse
Mankodi A, Lin X, Blaxall BC, Swanson MS, Thornton CA. Nuclear RNA foci in the heart in myotonic dystrophy. Circ Res;97(11):1152-5. 2005-11-25 [PMID: 16254211] (IHC-Fr, Human)	IHC-Fr	Human
Ami Mankodi, MD, Patana Teng-Umnuay, MD, PhD, Matt Krym, BSc, Don Henderson, BSc, Maurice Swanson, PhD, Charles A Thornton, MD. Ribonuclear Inclusions in Skeletal Muscle in Myotonic Dystrophy Types 1 2. Ann Neurol; 54:760. 2003-01-01 [PMID: 14681885] (ICC/IF, Human)	ICC/IF	Human
Savkur RS, Philips AV, Cooper TA. Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Nat Genet;29(1):40-7. 2001-09-01 [PMID: 11528389] (WB, Human)	WB	Human
Good PJ, Chen Q, Warner SJ, Herring DC. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. J Biol Chem;275(37):28583-92. 2000-09-15 [PMID: 10893231]
Show All 12 Publications. Collapse Publications.

Array NB200-316

• CUGBP1/CELF1 Antibodies
• CUGBP1/CELF1 Lysates
• CUGBP1/CELF1 Protein