CDK4 Antibody

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Bovine, Feline.

We have publications tested in 3 applications: FLOW, IHC-P, WB.

Showing Publications 1 - 7 of 7.

Publications using NBP1-31308	Applications	Species
Liu B, Fu C, Cao J Et al. Proliferation of bovine endometrial epithelial cells is promoted by prostaglandin E2-PTGER2 signaling through cell cycle regulation Prostaglandins, Leukotrienes and Essential Fatty Acids 2021-11-01 [PMID: 34740034] (WB, Bovine)	WB	Bovine
Chen BR, Wang Y, Tubbs A et al. LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells eLife 2021-09-03 [PMID: 34477552] (WB)	WB
Contractor T, Harris C Loss of copy of MIR1-2 increases CDK4 expression in ileal neuroendocrine tumors. Oncogenesis 2020-03-20 [PMID: 32198354] (FLOW, Human)	FLOW	Human
Fu C, Mao W, Gao R et al. Prostaglandin F2 alpha-PTGFR signaling promotes proliferation of endometrial epithelial cells of cattle through cell cycle regulation Anim. Reprod. Sci. 2020-02-01 [PMID: 31987327] (WB, Bovine)	WB	Bovine
Isohookana J, Haapasaari KM, Soini Y et al. Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma. Pathol Res Pract 2018-06-01 [PMID: 29735403] (Human)		Human
Poncelet L, Garigliany M, Ando K et al. Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus Cell Cycle. 2016-11-09 [PMID: 27830988] (IHC-P, Feline)	IHC-P	Feline
Huang AM, Kao YT, Toh S et al. UBE2M-mediated p27(kip1) degradation in gemcitabine cytotoxicity. Biochem Pharmacol 2011-07-01 [PMID: 21477582] (WB, Human)	WB	Human

Array NBP1-31308

• CDK4 Antibodies
• CDK4 ELISA Kits
• CDK4 Lysate
• CDK4 Proteins