Cochlin Antibody

The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: WB, Western Blot.

Showing Publications 1 - 2 of 2.

Publications using NBP1-69141	Applications	Species
Oh KS, Walls D, Joo SY et al. COCH-related autosomal dominant nonsyndromic hearing loss: a phenotype-genotype study Human Genetics 2022-04-01 [PMID: 34529116] (Western Blot)	Western Blot
Jung J, Yoo JE, Choe YH et al. Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear Cell Host Microbe 2019-03-20 [PMID: 30905438] (WB, Human)	WB	Human

Array NBP1-69141

• Cochlin Antibodies
• Cochlin Protein
• Cochlin ELISA
• Cochlin Proteins and Enzyme