CLOCK Antibody

Circadian Locomotor Output Cycles Kaput (CLOCK) is a bHLH/PAS protein that plays an important role in the molecular clock mechanism. Specifically, CLOCK activates the central circadian loop by stimulating expression of Period and Timeless proteins. CLOCK has also been shown to interact strongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform.

CLOCK levels peak during the late night and the early part of the subjective day. Mutations in CLOCK causes defective transcriptional activity and lengthens the circadian period, leading to abnormal circadian behavior.

CLOCK antibodies are useful tools for research on circadian rythmns, sleep biology and hormonal cycles.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Verified Customer	IHC-Fr	Other	09/11/2023	View Summary Application Immunohistochemistry-Frozen Sample Tested brain section Species Other Lot HD12DE0101 Comments Comments ***Novus Innovators Program - new species or application used on a primary antibody.*** 20um fixed-frozen brain tissue sections from Hyla cinerea. Chromogen target detection using DAB staining, no conclusive immunoreactive cell bodies in hypothalamus.

Array NBP2-97344

• CLOCK Antibodies
• CLOCK ELISA Kits
• CLOCK Lysate
• CLOCK Proteins