CLOCK Products

Description

Circadian Locomotor Output Cycles Kaput (CLOCK) is a bHLH/PAS protein that plays an important role in the molecular clock mechanism. Specifically, CLOCK activates the central circadian loop by stimulating expression of Period and Timeless proteins. CLOCK has also been shown to interact strongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform.

CLOCK levels peak during the late night and the early part of the subjective day. Mutations in CLOCK causes defective transcriptional activity and lengthens the circadian period, leading to abnormal circadian behavior.

CLOCK antibodies are useful tools for research on circadian rythmns, sleep biology and hormonal cycles.

Bioinformatics

Entrez	12753 Mouse 60447 Rat 9575 Human
Uniprot	NP_004889 Human O08785 Mouse O15516 Human
Product By Gene ID	9575
Alternate Names	BHLHE8 circadian locomoter output cycles protein kaput Class E basic helix-loop-helix protein 8 clock (mouse) homolog clock homolog (mouse) EC 2.3.1.48 hCLOCK KAT13D KIAA0334bHLHe8circadian locomoter output cycles kaput protein

Research Areas for CLOCK

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Circadian Rhythm
Hypoxia
Neuroscience
Signal Transduction
Transcription Factors and Regulators
Vision