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TIM-1/KIM-1/HAVCR Antibody [Unconjugated]

Name: TIM-1/KIM-1/HAVCR Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF1817
Price: 479 USD

(93 Publications)

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Western blot shows lysates of NIH-3T3 mouse embryonic fibroblast cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse TIM-1/KIM-1/HAVCR Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1817) ...read more

Exogenous biological renal support improved renal IRI and decreased mortality and serum Cr, BUN levels in old IRI mice. (A) Survival curves for the old IRI mice at 72 hours. (B) Cr levels in the old mice. (C) BUN levels ...read more

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	WB
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

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Biotin BAF1817

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Carrier Free AF1817-SP

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Biotin	BAF1817

TIM-1/KIM-1/HAVCR Antibody [Unconjugated] Summary

Immunogen	Mouse myeloma cell line NS0-derived recombinant mouse TIM‑1/KIM-1/HAVCR Tyr22-Thr212 Accession # NP_001160104
Specificity	Detects mouse TIM‑1/KIM-1/HAVCR in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human TIM-1, recombinant mouse (rm) TIM-2, rmTIM-3, rmTIM-4, rmTIM-6, and rmTIM-7 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	HAVCR1
Purity Statement	Antigen Affinity-purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Applications/Dilutions

Dilutions

Western Blot 0.25 ug/mL

Publications

Read Publications using
AF1817 in the following applications:

Flow Cytometry
1 publication
ICC
2 publications
IHC
24 publications
IHC-Fr
2 publications
IHC-P
2 publications
Western Blot
20 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TIM-1/KIM-1/HAVCR Antibody [Unconjugated]

CD365
HAVCR1
HAVCR-1
HAVCRT cell immunoglobin domain and mucin domain protein 1
hepatitis A virus cellular receptor 1
Kidney injury molecule 1
KIM1
KIM-1
T-cell immunoglobulin and mucin domain-containing protein 1
TIM1
TIM-1
TIM-1TIM
TIM1TIMD-1
TIMD1T-cell membrane protein 1

Background

TIM-1 (T cell-immunoglobulin-mucin; also KIM-1 and HAVCR) is a 70-80 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules (1-4). This gene family is involved in the regulation of Th1 and Th2-cell-mediated immunity. In mouse, there are eight known TIM genes (# 1-8) vs. only three genes in human (# 1, 3, and 4) (1, 2). Mouse TIM-1 and -2 are counterparts of human TIM-1 while mouse TIM-5 through 8 have no human counterparts (2). Mouse TIM-1 is synthesized as a 305 amino acid (aa) precursor that contains a 21 aa signal sequence, a 216 aa extracellular domain (ECD), a 21 aa transmembrane segment and a 47 aa cytoplasmic domain (5, 6). The ECD contains one V-type Ig-like domain and a mucin region characterized by multiple T-S-P motifs. The mucin region undergoes extensive O-linked glycosylation. The mouse TIM-1 gene is highly polymorphic and, based on rat, may undergo alternate splicing (4, 6). For instance, HBA mice show a 15 aa deletion in the mucin region that occurs in BALB/c mice (6). This difference is associated with a decreased susceptibility to asthma. Other polymorphisms are also documented (6). In human, TIM-1 is known to circulate as a soluble form. It undergoes constitutive cleavage by an undefined MMP, releasing a 75-85 kDa soluble molecule (5). The same thing might be expected in mouse. The ECD of mouse TIM-1 is 50%, 39%, and 80% aa identical to human, canine and rat TIM-1 ECD, respectively. The only two reported ligands for TIM-1 are TIM-4 and the hepatitis A virus (8, 9). However, others are believed to exist, and based on the ligand for TIM-3, one possibility might be an S-type lectin (10). TIM-1 ligation induces T cell proliferation and promotes cytokine production (1, 10). In particular, it induces IL-4 production, and requires the cytoplasmic tyrosine phosphorylation motif (5).

Meyers, J.H. et al. (2005) Trends Mol. Med. 11:1471.
Kuchroo, V.K. et al. (2003) Nat. Rev. Immunol. 3:454.
Mariat, C. et al. (2005) Phil. Trans. R. Soc. B 360:1681.
Ichimura, T. et al. (1998) J. Biol. Chem. 273:4135.
de Souza, A.J. et al. (2005) Proc. Natl. Acad. Sci. USA 102:17113.
McIntire, J.J. et al. (2001) Nat. Immunol. 2:1109.
Bailly, V. et al. (2002) J. Biol. Chem. 277:39739.
Feigelstock, D. et al. (1998) J. Virol. 72:6621.
Zhu, C. et al. (2005) Nat. Immunol. 6:1245.
Meyers, J.H. et al. (2005) Nat. Immunol. 6:455.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TIM-1/KIM-1/HAVCR Antibody (AF1817)(93)

We have publications tested in 3 confirmed species: Human, Mouse, Transgenic Mouse.

We have publications tested in 6 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Western Blot.

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Flow Cytometry

(1)

ICC

(2)

IHC

(24)

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(2)

IHC-P

(2)

Western Blot

(20)

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Human

(5)

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(40)

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Showing Publications 1 - 10 of 93. Show All 93 Publications.

Publications using AF1817	Applications	Species
Wang, W;Ren, X;Chen, X;Hong, Q;Cai, G; Integrin ?1-rich extracellular vesicles of kidney recruit Fn1+ macrophages to aggravate ischemia-reperfusion-induced inflammation JCI insight 2024-01-23 [PMID: 38258908] (Western Blot, Human, Mouse)	Western Blot	Human, Mouse
Cai, F;Li, D;Xie, Y;Wang, X;Ma, H;Xu, H;Cheng, J;Zhuang, H;Hua, ZC; Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells Redox biology 2023-11-29 [PMID: 38052107] (Western Blot, Human)	Western Blot	Human
Jin, X;He, R;Lin, Y;Liu, J;Wang, Y;Li, Z;Liao, Y;Yang, S; Shenshuaifu Granule Attenuates Acute Kidney Injury by Inhibiting Ferroptosis Mediated by p53/SLC7A11/GPX4 Pathway Drug design, development and therapy 2023-11-14 [PMID: 38024532] (Western Blot, Mouse)	Western Blot	Mouse
Shi, L;Zha, H;Pan, Z;Wang, J;Xia, Y;Li, H;Huang, H;Yue, R;Song, Z;Zhu, J; DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK Cell death & disease 2023-11-07 [PMID: 37935658] (IHC, Mouse)	IHC	Mouse
Yu, B;Jin, L;Yao, X;Zhang, Y;Zhang, G;Wang, F;Su, X;Fang, Q;Xiao, L;Yang, Y;Jiang, LH;Chen, J;Yang, W;Lin, W;Han, F; TRPM2 protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction via modulating autophagy Theranostics 2023-07-31 [PMID: 37649595] (IHC, ICC, Mouse)	IHC, ICC	Mouse
Deng, Z;Wang, Y;Liu, J;Zhang, H;Zhou, L;Zhao, H;Han, Y;Yan, S;Dong, Z;Wang, Y;Dai, Y;Deng, F; WBP2 restrains the lysosomal degradation of GPX4 to inhibit ferroptosis in cisplatin-induced acute kidney injury Redox biology 2023-07-26 [PMID: 37516014] (Western Blot, Mouse)	Western Blot	Mouse
Carlos Rey-Serra, Jessica Tituaña, Terry Lin, J Ignacio Herrero, Verónica Miguel, Coral Barbas et al. Reciprocal regulation between the molecular clock and kidney injury Life Science Alliance 2023-10-01 [PMID: 37487638]
Vlasschaert, C;Robinson-Cohen, C;Kestenbaum, B;Silver, SA;Chen, JC;Akwo, E;Bhatraju, PK;Zhang, MZ;Cao, S;Jiang, M;Wang, Y;Niu, A;Siew, E;Kramer, HJ;Kottgen, A;Franceschini, N;Psaty, BM;Tracy, RP;Alonso, A;Arking, DE;Coresh, J;Ballantyne, CM;Boerwinkle, E;Grams, M;Lanktree, MB;Rauh, MJ;Harris, RC;Bick, AG; Clonal Hematopoiesis of Indeterminate Potential is Associated with Acute Kidney Injury medRxiv : the preprint server for health sciences 2023-05-17 [PMID: 37292692] (Western Blot, Mouse)	Western Blot	Mouse
Hu X, Ma Z, Li S et al. Fibroblast Growth Factor 2 Is Produced By Renal Tubular Cells to Act as a Paracrine Factor in Maladaptive Kidney Repair After Cisplatin Nephrotoxicity Laboratory Investigation 2023-03-01 [PMID: 36925200]
K Hoeft, GJL Schaefer, H Kim, D Schumacher, T Bleckwehl, Q Long, BM Klinkhamme, F Peisker, L Koch, J Nagai, M Halder, S Ziegler, E Liehn, C Kuppe, J Kranz, S Menzel, I Costa, A Wahida, P Boor, RK Schneider, S Hayat, R Kramann Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner Cell Reports, 2023-02-17;42(2):112131. 2023-02-17 [PMID: 36807143] (IHC, Mouse)	IHC	Mouse
Z Zhao, G Li, Y Wang, Y Li, H Xu, W Liu, W Hao, Y Yao, R Zeng Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion International immunopharmacology, 2023-02-01;116(0):109757. 2023-02-01 [PMID: 36731154] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
Kenneth R. Hallows, Hui Li, Biagio Saitta, Saman Sepehr, Polly Huang, Jessica Pham et al. Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice Frontiers in Molecular Biosciences 2022-11-25 [PMID: 36504724]
Kensei Taguchi, Bertha C. Elias, Sho Sugahara, Snehal Sant, Benjamin S. Freedman, Sushrut S. Waikar et al. Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation Journal of Clinical Investigation 2022-12-01 [PMID: 36453545]
X Cao, J Wang, T Zhang, Z Liu, L Liu, Y Chen, Z Li, Y Zhao, Q Yu, T Liu, J Nie, Y Niu, Y Chen, L Yang, L Zhang Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury Nature Communications, 2022-11-28;13(1):7322. 2022-11-28 [PMID: 36443310] (IHC, Mouse)	IHC	Mouse
S Ide, K Ide, K Abe, Y Kobayashi, H Kitai, J McKey, SA Strausser, LL O'Brien, A Tata, PR Tata, T Souma Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair Cell Reports, 2022-11-08;41(6):111610. 2022-11-08 [PMID: 36351395] (IHC, Transgenic Mouse)	IHC	Transgenic Mouse
Banghua Zhang, Shanshan Wan, Hao Liu, Qiangmin Qiu, Hui Chen, Zhiyuan Chen et al. Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway Oxidative Medicine and Cellular Longevity 2022-10-10 [PMID: 36262286]
Lu Wen, Qingqing Wei, Man J. Livingston, Guie Dong, Siyao Li, Xiaoru Hu et al. PFKFB3 mediates tubular cell death in cisplatin nephrotoxicity by activating CDK4 Translational Research 2023-03-01 [PMID: 36243313]
Kayla R. McCullough, Juheb Akhter, Mauhaun J. Taheri, Amie Traylor, Anna A. Zmijewska, Vivek Verma et al. Functional consequence of myeloid ferritin heavy chain on acute and chronic effects of rhabdomyolysis-induced kidney injury Frontiers in Medicine 2022-09-08 [PMID: 36160140]
L Xu, J Guo, DG Moledina, LG Cantley Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition Nature Communications, 2022-08-19;13(1):4892. 8/19/2022 [PMID: 35986026]
Eman Y. Gohar, Rawan N. Almutlaq, Chunlan Fan, Rohan S. Balkawade, Maryam K. Butt, Lisa M. Curtis Does G Protein-Coupled Estrogen Receptor 1 Contribute to Cisplatin-Induced Acute Kidney Injury in Male Mice? International Journal of Molecular Sciences 2022-07-27 [PMID: 35955435]
LS Dalbøge, M Christense, MR Madsen, T Secher, N Endlich, V Drenic', A Manresa-Ar, HH Hansen, I Rune, LN Fink, MV Østergaard Nephroprotective Effects of Semaglutide as Mono- and Combination Treatment with Lisinopril in a Mouse Model of Hypertension-Accelerated Diabetic Kidney Disease Biomedicines, 2022-07-11;10(7):. 2022-07-11 [PMID: 35884965] (IHC, Mouse)	IHC	Mouse
Yizhuo Wang, Shuyun Liu, Lan Li, Ling Li, Xueli Zhou, Meihua Wan et al. Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections Journal of Controlled Release 2022-09-01 [PMID: 35792186]
Haojia Wu, Romer Gonzalez Gonzalez Villalobos, Xiang Yao, Dermot Reilly, Tao Chen, Matthew Rankin et al. Mapping the single-cell transcriptomic response of murine diabetic kidney disease to therapies Cell Metabolism 2022-07-01 [PMID: 35709763]
Albert Pérez-Martí, Suresh Ramakrishnan, Jiayi Li, Aurelien Dugourd, Martijn R Molenaar, Luigi R De La Motte et al. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes eLife 2022-05-12 [PMID: 35550039]
MJ Livingston, S Shu, Y Fan, Z Li, Q Jiao, XM Yin, MA Venkatacha, Z Dong Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis Autophagy, 2022-05-18;0(0):. 2022-05-18 [PMID: 35491858] (IHC, Mouse)	IHC	Mouse
Hanako Kobayashi, Olena Davidoff, Shiuli Pujari‐Palmer, Malin Drevin, Volker H. Haase EPO synthesis induced by HIF‐PHD inhibition is dependent on myofibroblast transdifferentiation and colocalizes with non‐injured nephron segments in murine kidney fibrosis Acta Physiol (Oxf) 2022-08-01 [PMID: 35491502]
Chen XC, Wu D, Wu HL et al. Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway Lupus Science & Medicine 2022-04-11 [PMID: 35414608]
T Eckes, S Patyna, A Koch, A Oftring, S Gauer, N Obermüller, S Schwalm, L Schaefer, J Chun, HJ Gröne, J Pfeilschif Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy International Journal of Molecular Sciences, 2022-04-02;23(7):. 2022-04-02 [PMID: 35409312] (Western Blot, Mouse)	Western Blot	Mouse
Blessy George, John T. Szilagyi, Melanie S. Joy, Lauren M. Aleksunes Regulation of renal calbindin expression during cisplatin‐induced kidney injury Journal of Biochemical and Molecular Toxicology 2022-07-01 [PMID: 35403300]
Kensei Taguchi, Bertha C. Elias, Evan Krystofiak, Subo Qian, Snehal Sant, Haichun Yang et al. Quantitative Super-Resolution Microscopy Reveals Promoting Mitochondrial Interconnectivity Protects against AKI Kidney360 2022-03-28 [PMID: 35342885]
Chen Yuqiang, Zhang Lisha, Wen Jiejun, Xue Qin, Wang Niansong Pifithrin-alpha ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation Renal Failure 2022-12-31 [PMID: 35285384]
TH Shen, J Stauber, K Xu, A Jacunski, N Paragas, M Callahan, R Banlengchi, AD Levitman, B Desanti de, A Beenken, MS Grau, E Mathieu, Q Zhang, Y Li, T Gopal, N Askanase, S Arumugam, S Mohan, PI Good, JS Stevens, F Lin, SK Sia, CS Lin, V D'Agati, K Kiryluk, NP Tatonetti, J Barasch Snapshots of nascent RNA reveal cell- and stimulus- specific responses to acute kidney injury JCI Insight, 2022-03-22;0(0):. 2022-03-22 [PMID: 35230973] (IHC, Mouse)	IHC	Mouse
EA Telford, AJ Sanders, S Owen, F Ruge, GM Harrison, WG Jiang, TA Martin Hepatitis A Virus Cellular Receptor 1 (HAVcr-1) Initiates Prostate Cancer Progression in Human Cells via Hepatocyte Growth Factor (HGF)-Induced Changes in Junctional Integrity Biomolecules, 2022-02-21;12(2):. 2022-02-21 [PMID: 35204839] (Western Blot, Human)	Western Blot	Human
S Wang, K Jing, H Wu, X Li, C Yang, T Li, H Tang, T Zou, Y She, HF Liu Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy Oxidative Medicine and Cellular Longevity, 2022-01-12;2022(0):2812493. 2022-01-12 [PMID: 35082964] (IHC, Mouse)	IHC	Mouse
Kensuke Sasaki, Andrew S. Terker, Jiaqi Tang, Shirong Cao, Juan Pablo Arroyo, Aolei Niu et al. Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis JCI Insight 2022-02-22 [PMID: 35025763]
N An, C Yang, HL Wu, Y Guo, XJ Huang, TS Huang, ZH Wu, J Xue, RH Chen, ZH Li, QJ Pan, HF Liu Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis Arthritis Research & Therapy, 2022-01-03;24(1):6. 2022-01-03 [PMID: 34980245] (IHC, Mouse)	IHC	Mouse
AR Schiazza, EG Considine, M Betcher, BD Shepard Loss of renal olfactory receptor 1393 leads to improved glucose homeostasis in a type 1 diabetic mouse model Physiological Reports, 2021-12-01;9(23):e15007. 2021-12-01 [PMID: 34877823] (Western Blot, Mouse)	Western Blot	Mouse
N Ma, Z Wei, J Hu, W Gu, X Ci Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway Frontiers in Pharmacology, 2021-11-11;12(0):768700. 2021-11-11 [PMID: 34858188] (Western Blot, Mouse, Transgenic Mouse)	Western Blot	Mouse, Transgenic Mouse
L Mulderrig, JI Garaycoech, ZK Tuong, CL Millington, FA Dingler, JR Ferdinand, L Gaul, JA Tadross, MJ Arends, S O'Rahilly, GP Crossan, MR Clatworthy, KJ Patel Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response Nature, 2021-11-24;600(7887):158-163. 2021-11-24 [PMID: 34819667] (IHC, Mouse)	IHC	Mouse
YK You, WF Wu, XR Huang, HD Li, YP Ren, JC Zeng, H Chen, HY Lan Deletion of Smad3 protects against C-reactive protein-induced renal fibrosis and inflammation in obstructive nephropathy International journal of biological sciences, 2021-09-21;17(14):3911-3922. 2021-09-21 [PMID: 34671208] (Western Blot, Mouse)	Western Blot	Mouse
Ranea-Robles P, Portman K, Bender A et al. Peroxisomal L-bifunctional protein (EHHADH) deficiency causes male-specific kidney hypertrophy and proximal tubular injury in mice Kidney360 2021-10-15 [PMID: 34651140]
Ryohei Kaseda, Michihiro Hosojima, Shoji Kuwahara, Hideyuki Kabasawa, Hiroyuki Aoki, Yuki Higuchi et al. Rice Endosperm Protein Improves the Anti-Inflammatory Effects of High-Density Lipoprotein and Produces Lower Atherosclerotic Lesion Accelerated by the Renal Mass Reduction than Casein in a Mouse Model Journal of the American Nutrition Association 2022-10-03 [PMID: 34424818]
Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A Strausser, Koki Abe, Savannah Herbek et al. Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair eLife 2021-07-19 [PMID: 34279220]
JC Lee, DM Yotis, JY Lee, MA Sarabusky, B Shrum, A Champagne, OZ Ismail, E Tutunea-Fa, HS Leong, L Gunaratnam Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma Scientific Reports, 2021-06-04;11(1):11840. 2021-06-04 [PMID: 34088927] (Western Blot, Human)	Western Blot	Human
Danielle E. Soranno, Lara Kirkbride-Romeo, Sara A. Wennersten, Kathy Ding, Maria A. Cavasin, Peter Baker et al. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition JACC: Basic to Translational Science 2021-02-22 [PMID: 33665513]
Verónica Miguel, Jessica Tituaña, J. Ignacio Herrero, Laura Herrero, Dolors Serra, Paula Cuevas et al. Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis Journal of Clinical Investigation 2021-03-01 [PMID: 33465052]
M Arita, S Watanabe, N Aoki, S Kuwahara, R Suzuki, S Goto, Y Abe, M Takahashi, M Sato, S Hokari, A Ohtsubo, S Shoji, K Nozaki, K Ichikawa, R Kondo, M Hayashi, Y Ohshima, H Kabasawa, M Hosojima, T Koya, A Saito, T Kikuchi Combination therapy of cisplatin with cilastatin enables an increased dose of cisplatin, enhancing its antitumor effect by suppression of nephrotoxicity Scientific Reports, 2021-01-12;11(1):750. 2021-01-12 [PMID: 33437029] (IHC, Mouse)	IHC	Mouse
Z Li, M Murakoshi, S Ichikawa, T Koshida, E Adachi, C Suzuki, S Ueda, T Gohda, Y Suzuki The sodium-glucose cotransporter 2 inhibitor tofogliflozin prevents diabetic kidney disease progression in type 2 diabetic mice FEBS Open Bio, 2020-11-10;0(0):. 2020-11-10 [PMID: 33098615] (IHC, Mouse)	IHC	Mouse
David Legouis, Sven-Erick Ricksten, Anna Faivre, Thomas Verissimo, Karim Gariani, Charles Verney et al. Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality Nature Metabolism 2020-07-20 [PMID: 32694833]
R Uni, T Inoue, Y Nakamura, D Fukaya, S Hasegawa, CH Wu, R Fujii, B Suratticha, W Peerapanya, A Ozeki, N Akimitsu, Y Wada, M Nangaku, R Inagi Vagus nerve stimulation even after injury ameliorates cisplatin-induced nephropathy via reducing macrophage infiltration Sci Rep, 2020-06-11;10(1):9472. 2020-06-11 [PMID: 32528023] (IHC, Mouse)	IHC	Mouse
M Zaidan, M Burtin, JD Zhang, T Blanc, P Barre, S Garbay, C Nguyen, F Vasseur, L Yammine, S Germano, L Badi, MC Gubler, M Gallazzini, G Friedlande, M Pontoglio, F Terzi Signaling pathways predisposing to chronic kidney disease progression JCI Insight, 2020-05-07;5(9):. 2020-05-07 [PMID: 32376805] (IHC, Mouse)	IHC	Mouse
MØ Nørgård, M Christense, H A M Mutsae, R Nørregaard Phenformin Attenuates Renal Injury in Unilateral Ureteral Obstructed Mice without Affecting Immune Cell Infiltration Pharmaceutics, 2020-03-26;12(4):. 2020-03-26 [PMID: 32224876] (IHC, Mouse)	IHC	Mouse
Barbara Mara Klinkhammer, Sonja Djudjaj, Uta Kunter, Runolfur Palsson, Vidar Orn Edvardsson, Thorsten Wiech et al. Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy Journal of the American Society of Nephrology 2020-04-01 [PMID: 32086278]
Jing Liu, Sanjeev Kumar, Andreas Heinzel, Michael Gao, Jinjin Guo, Gregory F. Alvarado et al. Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury Journal of the American Society of Nephrology 2020-04-01 [PMID: 32034106]
Shulin Cheng, Tao Wu, Yugen Li, Jing Huang, Tao Cai Romidepsin (FK228) in a Mouse Model of Lipopolysaccharide-Induced Acute Kidney Injury is Associated with Down-Regulation of the CYP2E1 Gene Medical Science Monitor 2020-01-18 [PMID: 31954012]
Suzuki C, Tanida I, Oliva Trejo JA, et al. Autophagy Deficiency in Renal Proximal Tubular Cells Leads to an Increase in Cellular Injury and Apoptosis under Normal Fed Conditions Int J Mol Sci 12/25/2019 [PMID: 31881660]
M Chang-Pane, FF Kadyrov, M Lalli, H Wu, S Ikeda, E Kefaloyian, MM Abdelmagee, A Herrlich, A Kobayashi, BD Humphreys FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury J. Clin. Invest., 2019-12-02;0(0):. 2019-12-02 [PMID: 31710314] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Michael Christensen, Mikkel Ø. Nørgård, Michael S. Jensen, Bjarne K. Møller, Rikke Nørregaard Metformin modulates immune cell infiltration into the kidney during unilateral ureteral obstruction in mice Physiological Reports 2019-07-01 [PMID: 31250538]
WZ Ying, X Li, S Rangarajan, W Feng, LM Curtis, PW Sanders Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury J. Clin. Invest., 2019-06-17;129(7):2792-2806. 2019-06-17 [PMID: 31205024] (IHC, Mouse)	IHC	Mouse
Stephanie L. K. Bowers, Stephanie Davis-Rodriguez, Zachary M. Thomas, Valeria Rudomanova, W. Clark Bacon, Alex Beiersdorfer et al. Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion American Journal of Physiology-Renal Physiology 2019-06-01 [PMID: 31017009]
Josselin Nespoux, Rohit Patel, Kelly L. Hudkins, Winnie Huang, Brent Freeman, Young Chul Kim et al. Gene deletion of the Na+-glucose cotransporter SGLT1 ameliorates kidney recovery in a murine model of acute kidney injury induced by ischemia-reperfusion American Journal of Physiology-Renal Physiology 2019-06-01 [PMID: 30995111]
Dong Liu, Zhiwei Yin, Qi Huang, Yi Ren, Diangeng Li, Linna Wang et al. Exogenous biological renal support ameliorates renal pathology after ischemia reperfusion injury in elderly mice Aging (Albany NY) 2019-04-12 [PMID: 30978173]
C Suzuki, I Tanida, M Ohmuraya, JA Oliva Trej, S Kakuta, T Sunabori, Y Uchiyama Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury Int J Mol Sci, 2019-04-05;20(7):. 2019-04-05 [PMID: 30959855] (ICC, Mouse)	ICC	Mouse
Bing Yang, Shanshan Lan, Mélanie Dieudé, Jean-Paul Sabo-Vatasescu, Annie Karakeussian-Rimbaud, Julie Turgeon et al. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury Journal of the American Society of Nephrology 2018-07-01 [PMID: 29925521]
E Lazzeri, ML Angelotti, A Peired, C Conte, JA Marschner, L Maggi, B Mazzinghi, D Lombardi, ME Melica, S Nardi, E Ronconi, A Sisti, G Antonelli, F Becherucci, L De Chiara, RR Guevara, A Burger, B Schaefer, F Annunziato, HJ Anders, L Lasagni, P Romagnani Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury Nat Commun, 2018-04-09;9(1):1344. 2018-04-09 [PMID: 29632300] (IHC, Mouse)	IHC	Mouse
O Maydan, PG McDade, Y Liu, XR Wu, DG Matsell, AA Eddy Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy Physiol Rep, 2018-03-01;6(6):e13654. 2018-03-01 [PMID: 29595914] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
M Zhao, Y Zhou, S Liu, L Li, Y Chen, J Cheng, Y Lu, J Liu Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury Drug Deliv, 2018-11-01;25(1):546-554. 2018-11-01 [PMID: 29451033] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Y Kim, SJ Park, SR Manson, CA Molina, K Kidd, H Thiessen-P, RJ Perry, H Liapis, S Kmoch, CR Parikh, AJ Bleyer, YM Chen Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease JCI Insight, 2017-12-07;2(23):. 2017-12-07 [PMID: 29212948] (Western Blot, Mouse)	Western Blot	Mouse
C Tang, H Han, M Yan, S Zhu, J Liu, Z Liu, L He, J Tan, Y Liu, H Liu, L Sun, S Duan, Y Peng, F Liu, XM Yin, Z Zhang, Z Dong PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against Renal ischemia-reperfusion injury Autophagy, 2018-02-17;0(0):1-45. 2018-02-17 [PMID: 29172924] (Western Blot, Mouse)	Western Blot	Mouse
Victoria L. Halperin Kuhns, Jennifer L. Pluznick Novel differences in renal gene expression in a diet-induced obesity model American Journal of Physiology-Renal Physiology 2018-04-01 [PMID: 29141937]
J Liu, S Kumar, E Dolzhenko, GF Alvarado, J Guo, C Lu, Y Chen, M Li, MC Dessing, RK Parvez, PE Cippà, AM Krautzberg, G Saribekyan, AD Smith, AP McMahon Molecular characterization of the transition from acute to chronic kidney injury following ischemia/reperfusion JCI Insight, 2017-09-21;2(18):. 2017-09-21 [PMID: 28931758] (IHC-P, Mouse)	IHC-P	Mouse
L Li, R Zviti, C Ha, ZV Wang, JA Hill, F Lin Forkhead Box O3 (FoxO3) Regulates Kidney Tubular Autophagy Following Urinary Tract Obstruction J. Biol. Chem., 2017-07-13;0(0):. 2017-07-13 [PMID: 28705935] (IHC, Mouse)	IHC	Mouse
Ravindra Boddu, Chunlan Fan, Sunil Rangarajan, Bhuvana Sunil, Subhashini Bolisetty, Lisa M. Curtis Unique sex- and age-dependent effects in protective pathways in acute kidney injury American Journal of Physiology-Renal Physiology 2017-09-01 [PMID: 28679590]
Takamasa Iwakura, Yoshihide Fujigaki, Tomoyuki Fujikura, Takayuki Tsuji, Naro Ohashi, Akihiko Kato et al. Cytoresistance after acute kidney injury is limited to the recovery period of proximal tubule integrity and possibly involves Hippo-YAP signaling Physiological Reports 2017-06-14 [PMID: 28611154]
Line Nilsson, Fredrik Palm, Rikke Nørregaard 15-Deoxy-delta 12,14-prostaglandin J2 Exerts Antioxidant Effects While Exacerbating Inflammation in Mice Subjected to Ureteral Obstruction Mediators of Inflammation 2017-04-19 [PMID: 28503033]
Yoshihisa Hori, Nobumasa Aoki, Shoji Kuwahara, Michihiro Hosojima, Ryohei Kaseda, Sawako Goto et al. Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity Journal of the American Society of Nephrology 2017-06-01 [PMID: 28052987]
JB Collier, RM Whitaker, ST Eblen, RG Schnellman Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor ? Coactivator-1? by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions J. Biol. Chem., 2016-11-14;291(52):26850-26859. 2016-11-14 [PMID: 27875304] (Western Blot, Mouse)	Western Blot	Mouse
Rescue therapy with Tanshinone IIA hinders transition of acute kidney injury to chronic kidney disease via targeting GSK3? Sci Rep, 2016-11-18;6(0):36698. 2016-11-18 [PMID: 27857162] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Ying Zhang, Qinggang Li, Dong Liu, Qi Huang, Guangyan Cai, Shaoyuan Cui et al. GDF11 improves tubular regeneration after acute kidney injury in elderly mice Scientific Reports 2016-10-05 [PMID: 27703192]
Rafael Kramann, Janewit Wongboonsin, Monica Chang-Panesso, Flavia G. Machado, Benjamin D. Humphreys Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury Journal of the American Society of Nephrology 2017-03-01 [PMID: 27624490]
Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury Sci Rep, 2016-09-07;6(0):32610. 2016-09-07 [PMID: 27600466] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Prasad R. Konkalmatt, Laureano D. Asico, Yanrong Zhang, Yu Yang, Cinthia Drachenberg, Xiaoxu Zheng et al. Renal rescue of dopamine D2 receptor function reverses renal injury and high blood pressure JCI Insight 2016-06-02 [PMID: 27358912]
Krisztina Fischer, F. Can Meral, Yongzhi Zhang, Mark G. Vangel, Ferenc A. Jolesz, Takaharu Ichimura et al. High-resolution renal perfusion mapping using contrast-enhanced ultrasonography in ischemia-reperfusion injury monitors changes in renal microperfusion Kidney International 2016-06-01 [PMID: 27165821]
Takehiro Suzuki, Hiroaki Yamaguchi, Motoi Kikusato, Osamu Hashizume, Satoru Nagatoishi, Akihiro Matsuo et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage Journal of the American Society of Nephrology 2016-07-01 [PMID: 26609120]
Ishida R, Kami D, Kusaba T, Kirita Y, Kishida T, Mazda O, Adachi T, Gojo S Kidney-specific Sonoporation-mediated Gene Transfer. Mol Ther, 2015-09-30;24(1):125-34. 2015-09-30 [PMID: 26419704] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Xueying Zhao, Chen Jiang, Rebecca Olufade, Dong Liu, Nerimiah Emmett Kidney Injury Molecule-1 Enhances Endocytosis of Albumin in Renal Proximal Tubular Cells Journal of Cellular Physiology 2016-04-01 [PMID: 26332568]
Brooks C, Yeung M, Brooks Y, Chen H, Ichimura T, Henderson J, Bonventre J KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation. EMBO J, 2015-08-17;34(19):2441-64. 8/17/2015 [PMID: 26282792]
Omar H. Maarouf, Anusha Aravamudhan, Deepika Rangarajan, Tetsuro Kusaba, Victor Zhang, Jeremy Welborn et al. Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk Journal of the American Society of Nephrology 2016-03-01 [PMID: 26204899]
Moller-Tank S, Albritton L, Rennert P, Maury W Characterizing functional domains for TIM-mediated enveloped virus entry. J Virol, 2014-04-02;88(12):6702-13. 2014-04-02 [PMID: 24696470] (Flow Cytometry, Human)	Flow Cytometry	Human
Abdul Soofi, Peng Zhang, Gregory R. Dressler Kielin/Chordin-Like Protein Attenuates both Acute and Chronic Renal Injury Journal of the American Society of Nephrology 2013-06-01 [PMID: 23539757]
Long-term rescue of dystrophin expression and improvement in muscle pathology and function in dystrophic mdx mice by peptide-conjugated morpholino. Am. J. Pathol., 2012-06-07;181(2):392-400. 2012-06-07 [PMID: 22683468] (Western Blot, Mouse)	Western Blot	Mouse
Humphreys BD, Czerniak S, DiRocco DP Repair of injured proximal tubule does not involve specialized progenitors. Proc. Natl. Acad. Sci. U.S.A., 2011-05-16;108(22):9226-31. 2011-05-16 [PMID: 21576461] (IHC-P, Mouse)	IHC-P	Mouse
Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, DeKruyff RH, Saito H, Galli SJ TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood, 2007-07-09;110(7):2565-8. 2007-07-09 [PMID: 17620455] (Western Blot, Mouse)	Western Blot	Mouse
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SH-SY5Y human neuroblastoma cell line was stained with Goat Anti-Human/Mouse/RatEphrin-B2 Antigen Affinity-purified Polyclonal Antibody (Catalog #AF496,filled histogram) or Normal Goat IgG Isotype Control Antibody(Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugatedAnti-Goat IgG Secondary Antibody (Catalog #F0107).

Goat IgG Isotype Control [Unconjugated]
AB-108-C

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.

TNF-alpha [Unconjugated]
210-TA-005

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Gene Symbol	HAVCR1
Uniprot	NP_001160104()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

TIM-1/KIM-1/HAVCR Antibody [Unconjugated]

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Publications for TIM-1/KIM-1/HAVCR Antibody (AF1817)(93)

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