CD44 Antibody

CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.1-6

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: ICC/IF, IF/IHC, IHC-Fr, IHC-P, In vitro, WB.

Showing Publications 1 - 10 of 13. Show All 13 Publications. Collapse Publications.

Publications using NBP1-31488	Applications	Species
Yoon C, Lu J, Jun Y et al. KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis Research Square 2022-12-06 (IHC-P, Mouse, Human)	IHC-P	Mouse, Human
Yoon C, Lu J, Jun Y et al. KRAS activation in gastric cancer stem-like cells promotes tumor angiogenesis and metastasis BMC cancer 2023-07-22 [PMID: 37481516] (IHC-P, Human)	IHC-P	Human
Mohanty S, Mohapatra P, Shriwas O et al. CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis bioRxiv 2021-08-20 [PMID: 36182968]
Lubanska D, Alrashed S, Mason GT et al. Impairing proliferation of glioblastoma multiforme with CD44+ selective conjugated polymer nanoparticles Scientific reports 2022-07-15 [PMID: 35840697] (ICC/IF)	ICC/IF
Kainulainen K, Takabe P, Heikkinen S et al. M1 macrophages induce pro-tumor inflammation in melanoma cells via TNFR-NF-kappa The Journal of investigative dermatology 2022-05-14 [PMID: 35580697] (ICC/IF, Human)	ICC/IF	Human
Patel U, Kannan S, Rane SU et al. Prognostic and predictive roles of cancer stem cell markers in head and neck squamous cell carcinoma patients receiving chemoradiotherapy with or without nimotuzumab British journal of cancer 2022-02-09 [PMID: 35140342] (IF/IHC, Human)	IF/IHC	Human
Lu J, Cao LL, Xu Y et al. FOXC1 modulates stem-like cell properties and chemoresistance through Hedgehog and EMT signaling in gastric adenocarcinoma Molecular therapy : the journal of the American Society of Gene Therapy 2021-09-14 [PMID: 34534693]
Mohapatra P, Shriwas O, Mohanty S, et al. CMTM6 drives cisplatin resistance by regulating Wnt signaling through ENO-1/AKT/GSK3 beta axis JCI insight 2021-01-12 [PMID: 33434185] (IF/IHC, Human)	IF/IHC	Human
D'Ascola A, Scuruchi M, Ruggeri RM et al. Hyaluronan oligosaccharides modulate inflammatory response, NIS and thyreoglobulin expression in human thyrocytes Arch. Biochem. Biophys. 2020-09-22 [PMID: 32976824] (WB, In vitro, Human)	WB, In vitro	Human
Shriwas O, Priyadarshini M, Samal SK et al. DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOG Apoptosis 2020-01-23 [PMID: 31974865]
You, K, Parikh, P Et al. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2019-11-01 [PMID: 31411059] (IF/IHC, Mouse)	IF/IHC	Mouse
Liang Y, Gao H, Lin Sy et al. Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model Oncogene et al. 2014-11-03 [PMID: 25362854] (IHC-Fr, Mouse) Details: CD25/IL-2 R alpha antibody used for IHC-Fr on thymus tissues from wild-type (WT) mice and primary lymphomas from Mcph1+/+p53-/-, Mcph1+/-p53-/-, and Mcph1-/-p53-/- mice. The antibody was used as the molecular marker for lymphocyte development and normal thymus was considered as control (Figure S8)	IHC-Fr	Mouse
Alberton P, Dex S, Popov C et al. Loss of tenomodulin results in reduced self-renewal and augmented senescence of tendon stem/progenitor cells. Stem Cells Dev. 2014-10-28 [PMID: 25351164]
Show All 13 Publications. Collapse Publications.

Array NBP1-31488

• CD44 Antibodies
• CD44 Antibody Pair
• CD44 ELISA Kits
• CD44 Lysates
• CD44 Protein
• CD44 ELISA
• CD44 Proteins and Enzymes