Clone HIP1 was used by HLDA to establish CD designation.
Immunogen
Peripheral blood mononuclear cells of a patient suffering with CLL.
Specificity
The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d. HLDA IV; WS Code P 40
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
GP1BA
Purity
Protein A purified
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Mouse reactivity reported in scientific literature (PMID: 31467123).
Packaging, Storage & Formulations
Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified
Notes
Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Alternate Names for CD42b/GPIb alpha Antibody (HIP1) [Alexa Fluor® 488]
Antigen CD42b-alpha
BP1BA
BSS
CD42b antigen
CD42b
CD42b-alpha
glycoprotein Ib (platelet), alpha polypeptide
Glycoprotein Ibalpha
GP1B
GP1BA
GPIb alpha
GP-Ib alpha
GPIbA
GPIb-alpha
MGC34595
platelet glycoprotein Ib alpha chain
platelet membrane glycoprotein 1b-alpha subunit
Background
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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