Reactivity | Hu, Rt, Pm-Cm, RbSpecies Glossary |
Applications | WB, ICC/IF, IHC |
Clone | C31.3 + C31.7 + C31.10 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | Janelia Fluor 549 |
Immunogen | Recombinant full-length human CD31/PECAM-1 protein (Uniprot: P16284) |
Localization | Cell surface and cytoplasm of endothelial cells |
Marker | Endothelial Cell Marker |
Specificity | CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 monoclonal antibody reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence. |
Isotype | IgG1 Kappa/IgG1 Kappa/IgG1 Kappa |
Clonality | Monoclonal |
Host | Mouse |
Gene | PECAM1 |
Purity | Protein A or G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Storage | Store at 4C in the dark. |
Buffer | 50mM Sodium Borate |
Preservative | 0.05% Sodium Azide |
Purity | Protein A or G purified |
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Gene Symbol | PECAM1 |