CD3 epsilon Antibody (145-2C11) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD3 is composed of five different polypeptides ranging from 16‑28 kDa that are associated with the T cell receptor (TCR) complex and serve as its signal transducing element. The CD3/TCR complex is expressed on T cells and thymocytes. Binding of immobilized anti-CD3 can cause T cell activation that leads to any of several consequences, depending on the conditions. Activation by anti-CD3 in the presence of IL 2 has been reported to induce cell death, apparently via apoptosis.⁴ The antibody can be used to induce cytolytic activity against non-specific targets and also to block TCR-mediated cytolytic killing.¹ 145-2C11 has been used in a variety of studies concerned with allograft rejection and graft-vs host reaction in mice.^{6, 7}

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: Bioassay, Functional Assay, Neutralization.

Showing Publications 1 - 10 of 18. Show All 18 Publications. Collapse Publications.

Publications using MAB484	Applications	Species
Gaurav Agrahari, Shyam Kishor Sah, Chul Hwan Bang, Yeong Ho Kim, Tae-Yoon Kim Superoxide Dismutase 3 Controls the Activation and Differentiation of CD4+T Cells Frontiers in Immunology 2/25/2021 [PMID: 33717151]
SJ Sidles, Y Xiong, MRI Young, AC LaRue High-Fat Diet Alters Immunogenic Properties of Circulating and Adipose Tissue-Associated Myeloid-Derived CD45+DDR2+ Cells Mediators Inflamm., 2019-02-28;2019(0):1648614. 2019-02-28 [PMID: 31015794] (Bioassay, Mouse)	Bioassay	Mouse
E Engelowski, NF Modares, S Gorressen, P Bouvain, D Semmler, C Alter, Z Ding, U Flögel, J Schrader, H Xu, PA Lang, J Fischer, DM Floss, J Scheller IL-23R Signaling Plays No Role in Myocardial Infarction Sci Rep, 2018-11-20;8(1):17078. 2018-11-20 [PMID: 30459442] (Bioassay, Mouse)	Bioassay	Mouse
B Caughron, Y Yang, MRI Young Role of IL-23 signaling in the progression of premalignant oral lesions to cancer PLoS ONE, 2018-04-17;13(4):e0196034. 4/17/2018 [PMID: 29664967]
T Savinko, C Guenther, LM Uotila, M Llort Asen, S Yao, S Tojkander, SC Fagerholm Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking J. Immunol., 2018-03-26;0(0):. 2018-03-26 [PMID: 29581355] (Functional Assay, Mouse)	Functional Assay	Mouse
LT McDonald, SD Johnson, DL Russell, MRI Young, AC LaRue Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis PLoS ONE, 2017-07-10;12(7):e0180724. 2017-07-10 [PMID: 28700752] (Bioassay, Mouse)	Bioassay	Mouse
Tan JL, Tan YZ, Muljadi R et al. Amnion Epithelial Cells Promote Lung Repair via Lipoxin A4. Stem Cells Transl Med. 4/1/2017 [PMID: 28371562]
H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao mTORC2 controls Th9 polarization and allergic airway inflammation Allergy, 2017-03-29;0(0):. 2017-03-29 [PMID: 28273354] (Functional Assay, Mouse)	Functional Assay	Mouse
H Kinosada, JI Yasunaga, K Shimura, P Miyazato, C Onishi, T Iyoda, K Inaba, M Matsuoka HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors PLoS Pathog, 2017-01-03;13(1):e1006120. 2017-01-03 [PMID: 28046066]
Jean L Tan, Siow T Chan, Camden Y Lo, James A Deane, Courtney A McDonald, Claude CA Bernard et al. Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response Stem Cell Research & Therapy 2015-12-01 [PMID: 25634246]
Gupta S, Marcel N, Talwar S, Garg M, R I, Perumalsamy L, Sarin A, Shivashankar G Developmental heterogeneity in DNA packaging patterns influences T-cell activation and transmigration. PLoS ONE, 2012-09-05;7(9):e43718. 2012-09-05 [PMID: 22957031] (Functional Assay, Mouse)	Functional Assay	Mouse
Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J., 2010-09-08;25(1):409-19. 2010-09-08 [PMID: 20826539] (Bioassay, Mouse)	Bioassay	Mouse
Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol., 2010-01-18;184(4):2130-9. 2010-01-18 [PMID: 20083667] (Neutralization, Mouse)	Neutralization	Mouse
Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, Okkenhaug K, Hagenbeek TJ, Spits H, Cantrell DA Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat. Immunol., 2008-04-06;9(5):513-21. 2008-04-06 [PMID: 18391955] (Functional Assay, Mouse)	Functional Assay	Mouse
Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H Protection of CD8+ T cells from activation-induced cell death by IL-18. J. Leukoc. Biol., 2007-03-30;82(1):142-51. 2007-03-30 [PMID: 17400610] (Functional Assay, Mouse)	Functional Assay	Mouse
Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells. J. Immunol., 2006-10-15;177(8):5041-50. 2006-10-15 [PMID: 17015687] (Functional Assay, Mouse)	Functional Assay	Mouse
Ogilvie RL, Abelson M, Hau HH, Vlasova I, Blackshear PJ, Bohjanen PR Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J. Immunol., 2005-01-15;174(2):953-61. 2005-01-15 [PMID: 15634918] (Functional Assay, Mouse)	Functional Assay	Mouse
Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J. Neurosci., 2004-07-07;24(27):6133-43. 2004-07-07 [PMID: 15240805] (Functional Assay, Mouse)	Functional Assay	Mouse
Show All 18 Publications. Collapse Publications.

Array MAB484

• CD3 epsilon Antibodies
• CD3 epsilon ELISA Kit
• CD3 epsilon Lysate
• CD3 epsilon Proteins
• CD3 epsilon Proteins and Enzyme