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CD1a Antibody (SPM120) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IHC, CyTOF-ready
Clone
SPM120
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-34731AF350
Alexa Fluor 405
NBP2-34731AF405
Alexa Fluor 488
NBP2-34731AF488
Alexa Fluor 532
NBP2-34731AF532
Alexa Fluor 594
NBP2-34731AF594
Alexa Fluor 647
NBP2-34731AF647
Alexa Fluor 700
NBP2-34731AF700
Alexa Fluor 750
NBP2-34731AF750
Allophycocyanin
NBP2-34731APC
Biotin
NBP2-34731B
CoraFluor 1
NBP2-34731CL1
DyLight 350
NBP2-34731UV
DyLight 405
NBP2-34731V
DyLight 488
NBP2-34731G
DyLight 550
NBP2-34731R
DyLight 594
NBP2-34731DL594
DyLight 650
NBP2-34731C
DyLight 680
NBP2-34731FR
DyLight 755
NBP2-34731IR
FITC
NBP2-34731F
HRP
NBP2-34731H
Janelia Fluor 525
NBP2-34731JF525
Janelia Fluor 646
NBP2-34731JF646
Janelia Fluor 669
NBP2-34731JF669
PE
NBP2-34731PE
PerCP
NBP2-34731PCP
Unconjugated
NBP2-33017-0.1mg
mFluor Violet 450 SE
NBP2-34731MFV450
mFluor Violet 500 SE
NBP2-34731MFV500
mFluor Violet 610 SE
NBP2-34731MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-33017-0.1mg
IHC-Prediluted
NBP2-45342
Azide and BSA Free
NBP2-34731-0.1mg
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CD1a Antibody (SPM120) [Janelia Fluor® 549] Summary

Immunogen
Human thymus cells
Specificity
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa)
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CD1A
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for CD1a Antibody (SPM120) [Janelia Fluor® 549]

  • CD1
  • CD1a antigen
  • CD1A antigen, a polypeptide
  • CD1a molecule
  • CD1a
  • cluster of differentiation 1 A
  • cortical thymocyte antigen CD1A
  • differentiation antigen CD1-alpha-3
  • epidermal dendritic cell marker CD1a
  • FCB6
  • hTa1 thymocyte antigen
  • HTA1
  • R4
  • T6
  • T-cell surface antigen T6/Leu-6
  • T-cell surface glycoprotein CD1a

Background

All CD1 molecules, except CD1e, are cell surface glycoproteins that are structurally related to the MHC molecules, however, in distinction, CD1 proteins are essentially non polymorphic. CD1 has considerable structural homology with both MHC class I and class II molecules, and CD1 molecules are involved in T cell activation. In contrast to MHC, however, CD1 molecules appear to present predominantly non peptide molecules originating from lipids and glycolipids.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NBP2-34731JF549
CD1a Antibody (SPM120) [Janelia Fluor® 549]
Species: Hu
Applications: Flow, ICC/IF, IHC, CyTOF-ready

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Bioinformatics

Gene Symbol CD1A