ACAT1 Antibody

Sterol O-acyltransferase 1 (SOAT1), also known as ACAT1, catalyzes the formation of intracellular cholesterol esters in various tissues, such as adult human liver, adrenal glands, macrophages, and kidneys. Specifically, ACAT-1 catalyzes the reversible reaction forming acetoacetyl-CoA from two molecules of acetyl-CoA. Additionaly, the ACAT 1 protein may have a role in lipoprotein assembly and dietary cholesterol absorption, and may also act as a ligase.

Mutations in this gene have been associated with 3-ketothiolase deficiency, an inborn defect of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using NBP1-89284	Applications	Species
Andersson S, Konrad A, Ashok N et al. Antibodies Biotinylated Using a Synthetic Z-domain from Protein A Provide Stringent In Situ Protein Detection. J Histochem Cytochem 2013-11-01 [PMID: 23920108]
Chang HT, Olson LK, Schwartz KA. Ketolytic and glycolytic enzymatic expression profiles in malignant gliomas: implication for ketogenic diet therapy. Nutr Metab (Lond) 2013-07-05 [PMID: 23829383]
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D et al. Ketone body utilization drives tumor growth and metastasis. Cell Cycle 2012-11-01 [PMID: 23082722]
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D et al. Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell Cycle 2012-11-01 [PMID: 23082721]
Stadler C, Hjelmare M, Neumann B et al. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. J Proteomics 2012-04-03 [PMID: 22361696]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Jennifer McGuire	WB	Pig	07/24/2018	View Summary Application Western Blot Sample Tested Brain (cerebral cortex),brain cortical homogenate Species Pig Lot A113800 Comments Comments primary concentration 1:500, Secondary concentration 1:10,000

Array NBP1-89284

• ACAT1 Antibodies
• ACAT1 Proteins
• ACAT1 Proteins and Enzyme