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CCR6 Antibody (140706) [Unconjugated]

 (13 Publications)
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Mouse splenocytes were stained with (A) Rat Anti-Mouse CCR6 Monoclonal Antibody (Catalog # MAB590) or (B) Rat IgG2A control antibody (Catalog # MAB006) followed by Goat anti-Rat IgG APC-conjugated Secondary Antibody (Catalog # F0113) and Rat Anti-Mouse B220/CD45R Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1217F). View our protocol for Staining Membrane-associated Proteins.
Mouse splenocytes were stained with (A) Rat Anti-Mouse CCR6 Monoclonal Antibody (Catalog # MAB590) or (B) Rat IgG2A control antibody (Catalog # MAB006) followed by Goat anti-Rat IgG APC-conjugated Secondary Antibody ...read more
CCR6 was detected in perfusion fixed frozen sections of mouse thymus using Mouse CCR6 Monoclonal Antibody (Catalog # MAB590) at 8 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell & ...read more
CCR6 was detected in immersion fixed frozen sections of mouse spleen using Rat Anti-Mouse CCR6 Monoclonal Antibody (Catalog # MAB590) at 0.3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat HRP-DAB Cell ...read more
Priming of pik3cg−/− CD4+ T cells is reduced during EAE.(A) Frequencies of CD4+ cells in draining LN that are CD69+ on day 9 post-immunisation for EAE as determined by flow cytometry. A representative histogram ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
140706
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB590U-100UG
Alexa Fluor 405
FAB590V-100UG
Alexa Fluor 488
FAB590G-025
Alexa Fluor 488
FAB590G-100
Alexa Fluor 532
FAB590X
Alexa Fluor 594
FAB590T-100UG
Alexa Fluor 647
FAB590R-100UG
Alexa Fluor 700
FAB590N-100UG
Alexa Fluor 750
FAB590S-100UG
Allophycocyanin
FAB590A-025
Allophycocyanin
FAB590A-100
Allophycocyanin/Cy7
FAB590APCCY7
Biotin
FAB590B
CoraFluor 1
FAB590CL1
DyLight 350
FAB590D
DyLight 405
FAB590E
DyLight 488
FAB590K
DyLight 550
FAB590L
DyLight 594
FAB590M
DyLight 650
FAB590W
DyLight 680
FAB590Y
DyLight 755
FAB590Z
HRP
FAB590H
Janelia Fluor 525
FAB590JF525
Janelia Fluor 549
FAB590I
Janelia Fluor 585
FAB590JF585
Janelia Fluor 635
FAB590JF635
Janelia Fluor 646
FAB590J
Janelia Fluor 669
FAB590JF669
PE/Atto594
FAB590PEATT594
PE/Cy5.5
FAB590PECY55
PE/Cy7
FAB590PECY7
PerCP
FAB590C
Phycoerythrin
FAB590P-100
Phycoerythrin
FAB590P-025
mFluor Violet 450 SE
FAB590MFV450
mFluor Violet 500 SE
FAB590MFV500
mFluor Violet 610 SE
FAB590MFV610
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
FAB590P-025
Carrier Free
FAB590P-100
Carrier Free
FAB590A-025
Carrier Free
FAB590A-100
Carrier Free
FAB590G-025
Carrier Free
FAB590G-100
Carrier Free
MAB590-SP
Carrier Free
FAB590V-100UG
Carrier Free
FAB590U-100UG
Carrier Free
FAB590T-100UG
Carrier Free
FAB590S-100UG
Carrier Free
FAB590R-100UG
Carrier Free
FAB590N-100UG
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CCR6 Antibody (140706) [Unconjugated] Summary

Immunogen
RBL-1 rat basophilic leukemia cell line transfected with mouse CCR6
Met1-Met367
Accession # O54689
Specificity
Detects mouse CCR6-transfected rat RBL cells but not the parent cell line or cells transfected with mouse CCR5.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Rat
Gene
CCR6
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publications using
MAB590 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CCR6 Antibody (140706) [Unconjugated]

  • BN-1
  • CC-CKR-6
  • CCR6
  • CCR-6
  • CD196 antigen
  • CD196
  • chemokine (C-C motif) receptor 6
  • CKRL3
  • CKR-L3
  • CKR-L3G-protein coupled receptor 29
  • CKRL3LARC receptor
  • CMKBR6
  • CMKBR6STRL22
  • DRY6
  • GPR29
  • GPR29C-C CKR-6
  • GPRCY4
  • GPR-CY4
  • GPRCY4DRY-6
  • lymphocyte, 22
  • STRL22

Background

CCR6 is a seven transmembrane-spanning G protein-coupled receptor that binds the chemokine MIP-3 alpha and mediates the chemoattraction of B and T lymphocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CCR6 Antibody
(140706) [Unconjugate
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CCR6 Antibody (140706) [Unconjugated]
Species: Mu
Applications: Flow, IHC, CyTOF-ready

Publications for CCR6 Antibody (MAB590)(13)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 5 applications: ELISA Development (Capture), Flow Cytometry, IHC, IHC-Fr, Neutralization.


Filter By Application
ELISA Development (Capture)
(1)
Flow Cytometry
(5)
IHC
(1)
IHC-Fr
(1)
Neutralization
(1)
All Applications
Filter By Species
Mouse
(9)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using MAB590 Applications Species
Lavoisier Akoolo, Vitomir Djokic, Sandra C. Rocha, Luis Ulloa, Nikhat Parveen Sciatic–Vagal Nerve Stimulation by Electroacupuncture Alleviates Inflammatory Arthritis in Lyme Disease-Susceptible C3H Mice Frontiers in Immunology 2022-07-18 [PMID: 35924250]
A Muschaweck, F Petermann, T Korn IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855314] (Flow Cytometry, Mouse) Flow Cytometry Mouse
SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin J. Immunol, 2016-02-05;196(6):2514-25. 2016-02-05 [PMID: 26851219] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Boyle S, Faulkner J, McColl S, Kochetkova M The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages. Mol Cancer, 2015-06-06;14(0):115. 2015-06-06 [PMID: 26047945] (ELISA Development (Capture), Mouse) ELISA Development (Capture) Mouse
Liu , Jinlin, Ke , Fang, Xu , Zhenyao, Liu , Zhaoyuan, Zhang , Lingyun, Yan , Sha, Wang , Zhe, Wang , Hong, Wang , Honglin CCR6 is a prognostic marker for overall survival in patients with colorectal cancer, and its overexpression enhances metastasis in vivo. PLoS ONE, 2014-06-30;9(6):e101137. 2014-06-30 [PMID: 24979261] (Neutralization, Mouse) Neutralization Mouse
Zhao P, Hou L, Farley K, Sundrud M, Remold-O'Donnell E SerpinB1 regulates homeostatic expansion of IL-17+ gammadelta and CD4+ Th17 cells. J Leukoc Biol, 2013-11-18;95(3):521-30. 2013-11-18 [PMID: 24249741] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Pedro Caballero-Campo, Mariano G. Buffone, Fabian Benencia, José R. Conejo-García, Paolo F. Rinaudo, George L. Gerton A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis Journal of Cellular Physiology 2013-08-02 [PMID: 23765988]
Hu S, Xiong N Programmed downregulation of CCR6 is important for establishment of epidermal gammadeltaT cells by regulating their thymic egress and epidermal location. J Immunol, 2013-02-18;190(7):3267-75. 2013-02-18 [PMID: 23420888] (Flow Cytometry, Mouse) Flow Cytometry Mouse
Iain Comerford, Wendel Litchfield, Ervin Kara, Shaun R. McColl PI3K gamma drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis PLoS ONE 2012-09-13 [PMID: 23028778]
Baptista A, Olivier B, Goverse G, Greuter M, Knippenberg M, Kusser K, Domingues R, Veiga-Fernandes H, Luster A, Lugering A, Randall T, Cupedo T, Mebius R Colonic patch and colonic SILT development are independent and differentially regulated events. Mucosal Immunol, 2012-09-19;6(3):511-21. 2012-09-19 [PMID: 22990625] (IHC, Mouse) IHC Mouse
Show All 13 Publications.

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Bioinformatics

Gene Symbol CCR6
Uniprot