Name: CCR5 Antibody (45502)
Brand: Novus Biologicals
SKU: MAB180
Rating: 3 (1 reviews)

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	Flow, CyTOF-ready
Clone	45502
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB180U-100UG

Alexa Fluor 405 FAB180V-100UG

Alexa Fluor 488 FAB180G-100UG

Alexa Fluor 532 FAB180X

Alexa Fluor 594 FAB180T-100UG

Alexa Fluor 647 FAB180R-100UG

Alexa Fluor 700 FAB180N-100UG

Alexa Fluor 750 FAB180S-100UG

Allophycocyanin FAB180A

Allophycocyanin/Cy7 FAB180APCCY7

CoraFluor 1 FAB180CL1

DyLight 350 FAB180D

DyLight 405 FAB180E

DyLight 488 FAB180K

DyLight 550 FAB180L

DyLight 594 FAB180M

DyLight 650 FAB180W

DyLight 680 FAB180Y

DyLight 755 FAB180Z

HRP FAB180H

Janelia Fluor 525 FAB180JF525

Janelia Fluor 549 FAB180I

Janelia Fluor 646 FAB180J

Janelia Fluor 669 FAB180JF669

PE FAB180P

PE/Atto594 FAB180PEATT594

PE/Cy5.5 FAB180PECY55

PE/Cy7 FAB180PECY7

PerCP FAB180C

mFluor Violet 450 SE FAB180MFV450

mFluor Violet 500 SE FAB180MFV500

mFluor Violet 610 SE FAB180MFV610

Catalog# & Formulation	Size	Price
Carrier Free MAB180-SP

Carrier Free FAB180V-100UG

Carrier Free FAB180U-100UG

Carrier Free FAB180T-100UG

Carrier Free FAB180S-100UG

Carrier Free FAB180R-100UG

Carrier Free FAB180N-100UG

Carrier Free FAB180G-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB180U-100UG
Alexa Fluor 405	FAB180V-100UG
Alexa Fluor 488	FAB180G-100UG
Alexa Fluor 532	FAB180X
Alexa Fluor 594	FAB180T-100UG
Alexa Fluor 647	FAB180R-100UG
Alexa Fluor 700	FAB180N-100UG
Alexa Fluor 750	FAB180S-100UG
Allophycocyanin	FAB180A
Allophycocyanin/Cy7	FAB180APCCY7
CoraFluor 1	FAB180CL1
DyLight 350	FAB180D
DyLight 405	FAB180E
DyLight 488	FAB180K
DyLight 550	FAB180L
DyLight 594	FAB180M
DyLight 650	FAB180W
DyLight 680	FAB180Y
DyLight 755	FAB180Z
HRP	FAB180H
Janelia Fluor 525	FAB180JF525
Janelia Fluor 549	FAB180I
Janelia Fluor 646	FAB180J
Janelia Fluor 669	FAB180JF669
PE	FAB180P
PE/Atto594	FAB180PEATT594
PE/Cy5.5	FAB180PECY55
PE/Cy7	FAB180PECY7
PerCP	FAB180C
mFluor Violet 450 SE	FAB180MFV450
mFluor Violet 500 SE	FAB180MFV500
mFluor Violet 610 SE	FAB180MFV610

CCR5 Antibody (45502)

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Publications for CCR5 Antibody (MAB180)(8)

Review for CCR5 Antibody (MAB180) (1) 31

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Immunogen	NS0 mouse myeloma cell line transfected with human CCR5 Met1-Leu352 Accession # P51681
Specificity	Specifically stains human CCR5 transfectants but not the parental cell line as detected by flow cytometry. It has also been shown to react with a CCR5/CCR2 chimera (5222) containing the amino-terminal domain of CCR5. However, this antibody does not react with CCR5 present on unfixed stimulated human PBMCs by flow cytometry. For additional information regarding epitope specificity for this antibody and other R&D Systems anti-human CCR5 antibodies, see Lee, B. et al., 1999, J. Biol. Chem. 274:9617.
Source	N/A
Isotype	IgG2b
Clonality	Monoclonal
Host	Mouse
Gene	CCR5
Purity Statement	Protein A or G purified from ascites
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB180	Applications	Species
RD Macarie, M Vadana, L Ciortan, MM Tucureanu, A Ciobanu, D Vinereanu, I Manduteanu, M Simionescu, E Butoi The expression of MMP-1 and MMP-9 is up-regulated by smooth muscle cells after their cross-talk with macrophages in high glucose conditions J. Cell. Mol. Med., 2018-07-10;0(0):. 2018-07-10 [PMID: 29992758] (Western Blot, Human)	Western Blot	Human
Chain B, Arnold J, Akthar S, Brandt M, Davis D, Noursadeghi M, Lapp T, Ji C, Sankuratri S, Zhang Y, Govada L, Saridakis E, Chayen N A Linear Epitope in the N-Terminal Domain of CCR5 and Its Interaction with Antibody. PLoS ONE, 2015-06-01;10(6):e0128381. 2015-06-01 [PMID: 26030924] (ELISA Development, Human)	ELISA Development	Human
James M. Fox, Richard Kasprowicz, Oliver Hartley, Nathalie Signoret CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells Journal of Leukocyte Biology 2015-07-01 [PMID: 25957306]
Carrega , Paolo, Bonaccorsi , Irene, Di Carlo , Emma, Morandi , Barbara, Paul , Petra, Rizzello , Valeria, Cipollone , Giuseppe, Navarra , Giuseppe, Mingari , Maria Cr, Moretta , Lorenzo, Ferlazzo , Guido CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph. J Immunol, 2014-03-19;192(8):3805-15. 2014-03-19 [PMID: 24646734] (Flow Cytometry, Human)	Flow Cytometry	Human
Ogawa Y, Kawamura T, Kimura T, Ito M, Blauvelt A, Shimada S Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation. Blood, 2009-03-11;113(21):5157-66. 2009-03-11 [PMID: 19279330] (Flow Cytometry, Human)	Flow Cytometry	Human
Ponte AL, Marais E, Gallay N, Langonne A, Delorme B, Herault O, Charbord P, Domenech J The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Stem Cells, 2007-03-29;25(7):1737-45. 2007-03-29 [PMID: 17395768] (Flow Cytometry, Human)	Flow Cytometry	Human
Ottonello L, Montecucco F, Bertolotto M, Arduino N, Mancini M, Corcione A, Pistoia V, Dallegri F CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2. Cell. Signal., 2005-03-01;17(3):355-63. 2005-03-01 [PMID: 15567066] (Flow Cytometry, Human)	Flow Cytometry	Human
Lee B, Sharron M, Blanpain C, Doranz BJ, Vakili J, Setoh P, Berg E, Liu G, Guy HR, Durell SR, Parmentier M, Chang CN, Price K, Tsang M, Doms RW Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function. J. Biol. Chem., 1999-04-02;274(14):9617-26. 1999-04-02 [PMID: 10092648] (Flow Cytometry, Human)	Flow Cytometry	Human

	Verified Customer 02/10/2015
Application:	Flow
Species:	Human

Gene Symbol	CCR5
Uniprot	P51681()