Name: CCL11/Eotaxin Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF-420-NA
Price: 489 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	MuSpecies Glossary
Applications	WB, IHC, B/N, ELISA(Cap)
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF420

Immunogen	E. coli-derived recombinant mouse CCL11/Eotaxin His24-Pro97 Accession # P48298
Specificity	Detects mouse CCL11/Eotaxin in ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant human CCL11/Eotaxin is observed, and less than 5% cross-reactivity with recombinant mouse JE is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	CCL11
Purity Statement	Antigen Affinity-purified
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

CCL11/Eotaxin Antibody [Unconjugated]

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CCL11/Eotaxin Antibody [Unconjugated] Summary

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Publications for CCL11/Eotaxin Antibody (AF-420-NA)(23)

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Bioinformatics

Publications using AF-420-NA	Applications	Species
Emilie J. Cosway, Andrea J. White, Sonia M. Parnell, Edina Schweighoffer, Helen E. Jolin, Andrea Bacon et al. Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration Science Immunology 3/11/2022 [PMID: 35275754]
HS Choi, T Won, X Hou, G Chen, W Bracamonte, MV Talor, I Jur?ová, O Szárszoi, L ?urnova, I St?íž, JE Hooper, V Melenovský, D ?iháková Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis Cell Rep, 2020-03-03;30(9):2989-3003.e6. 2020-03-03 [PMID: 32130902] (IHC, Mouse)	IHC	Mouse
M Boström, M Kalm, Y Eriksson, C Bull, A Ståhlberg, T Björk-Erik, N Hellström, K Blomgren A role for endothelial cells in radiation-induced inflammation Int. J. Radiat. Biol., 2018-02-07;0(0):1-36. 2018-02-07 [PMID: 29359989] (IHC, Mouse)	IHC	Mouse
AM Henschel, SM Cabrera, ML Kaldunski, S Jia, R Geoffrey, MF Roethle, V Lam, YG Chen, X Wang, NH Salzman, MJ Hessner Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and ?-cell chemokine expression associated with autoimmune diabetes susceptibility PLoS ONE, 2018-01-02;13(1):e0190351. 2018-01-02 [PMID: 29293587] (IHC, Rat)	IHC	Rat
E Kindstedt, CK Holm, R Sulniute, I Martinez-C, R Lundmark, P Lundberg CCL11, a novel mediator of inflammatory bone resorption Sci Rep, 2017-07-13;7(1):5334. 2017-07-13 [PMID: 28706221] (IHC, Mouse)	IHC	Mouse
Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart Eur J Immunol, 2016-10-25;0(0):. 2016-10-25 [PMID: 27621211] (IHC-P, Mouse)	IHC-P	Mouse
Chao G, Wallis R, Marandi L, Ning T, Sarmiento J, Paterson A, Poussier P Iddm30 controls pancreatic expression of Ccl11 (Eotaxin) and the Th1/Th2 balance within the insulitic lesions. J Immunol, 2014-03-19;192(8):3645-53. 2014-03-19 [PMID: 24646746] (IHC-Fr, Western Blot, Rat)	IHC-Fr, Western Blot	Rat
Oh Sasaki, Mitsuru Imamura, Yusuke Yamazumi, Hiroaki Harada, Taku Matsumoto, Katsuhide Okunishi et al. Alendronate Attenuates Eosinophilic Airway Inflammation Associated with Suppression of Th2 Cytokines, Th17 Cytokines, and Eotaxin-2 The Journal of Immunology 9/15/2013 [PMID: 23935198]
Mizutani , Takeshi, Ashikari , Masayuki, Tokoro , Mayumi, Nozaki , Miho, Ogura , Yuichiro Suppression of laser-induced choroidal neovascularization by a CCR3 antagonist. Invest Ophthalmol Vis Sci, 2013-02-28;54(2):1564-72. 2013-02-28 [PMID: 23404125] (IHC, Mouse)	IHC	Mouse
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, Salzman P, Wang W, Liu C, Vidyasagar S, Zhang L, Ju S, Okunieff P, Zhang L Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine, 2012-01-25;58(2):169-77. 2012-01-25 [PMID: 22277799] (Luminex Development, Mouse)	Luminex Development	Mouse
Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Despres S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 2011-08-31;477(7362):90-4. 2011-08-31 [PMID: 21886162] (Neutralization, Mouse)	Neutralization	Mouse
Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D Comprehensive assessment of chemokine expression profiles by flow cytometry. J. Clin. Invest., 2010-02-08;120(3):907-23. 2010-02-08 [PMID: 20197626] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Wendy T. Watford, Chun-Chi Wang, Christos Tsatsanis, Lisa A. Mielke, Aristides G. Eliopoulos, Constantine Daskalakis et al. Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice The Journal of Immunology 1/1/2010 [PMID: 19955521]
De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA House dust mite induces direct airway inflammation in vivo: implications for future disease therapy? Eur. Respir. J., 2009-10-19;35(6):1377-87. 2009-10-19 [PMID: 19840954] (IHC-P, Rat)	IHC-P	Rat
Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature, 2009-06-14;460(7252):225-30. 2009-06-14 [PMID: 19525930] (Neutralization, Mouse)	Neutralization	Mouse
Kearley J, Buckland KF, Mathie SA, Lloyd CM Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am. J. Respir. Crit. Care Med., 2009-01-29;179(9):772-81. 2009-01-29 [PMID: 19179489] (ELISA Development, Mouse)	ELISA Development	Mouse
Wilson MS, Elnekave E, Mentink-Kane MM, Hodges MG, Pesce JT, Ramalingam TR, Thompson RW, Kamanaka M, Flavell RA, Keane-Myers A, Cheever AW, Wynn TA IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J. Clin. Invest., 2007-10-01;117(10):2941-51. 2007-10-01 [PMID: 17885690] (Mouse)		Mouse
D&apos;Avila H, Almeida PE, Roque NR, Castro-Faria-Neto HC, Bozza PT Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by Mycobacterium bovis BCG pleurisy. Infect. Immun., 2006-12-11;75(3):1507-11. 2006-12-11 [PMID: 17158890] (Neutralization, Mouse)	Neutralization	Mouse
Osuchowski MF, Welch K, Siddiqui J, Remick DG Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol., 2006-08-01;177(3):1967-74. 2006-08-01 [PMID: 16849510] (ELISA Development, Mouse)	ELISA Development	Mouse
Osuchowski MF, Siddiqui J, Copeland S, Remick DG Sequential ELISA to profile multiple cytokines from small volumes. J. Immunol. Methods, 2005-07-01;302(1):172-81. 2005-07-01 [PMID: 16023134] (ELISA Development, Mouse)	ELISA Development	Mouse
Reading PC, Symons JA, Smith GL A soluble chemokine-binding protein from vaccinia virus reduces virus virulence and the inflammatory response to infection. J. Immunol., 2003-02-01;170(3):1435-42. 2003-02-01 [PMID: 12538705] (ELISA Development, Human)	ELISA Development	Human
Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J. Leukoc. Biol., 2003-01-01;73(1):65-73. 2003-01-01 [PMID: 12525563] (ELISA Development, Mouse)	ELISA Development	Mouse
Lukacs NW, Berlin A, Schols D, Skerlj RT, Bridger GJ AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am. J. Pathol., 2002-04-01;160(4):1353-60. 2002-04-01 [PMID: 11943720] (ELISA Development, Human)	ELISA Development	Human
Show All 23 Publications. Collapse Publications.

Catalog# & Formulation	Size	Price
Carrier Free AF-420-SP

Gene Symbol	CCL11
Uniprot	P48298()