Cathepsin L Antibody (193702)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The pro form of insect cell Cathepsin L is stable at neutral pH, but autoactivates in acidic buffers under reducing conditions. The activated enzyme is similar in substrate specificity to mammalian Cathepsin L, and is very active as a protease, as judged by its ability to degrade azocasein. Cystatins A, B, C, E/M, F, SA, and SN are potent inhibitors of the insect cell Cathepsin L. Like other cysteine proteases related to papain, insect cell Cathepsin L is also inhibited by E-64 and reagents which react with thiols.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Drosophila, Drosophila melanogaster, Insect.

We have publications tested in 3 applications: IHC, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using MAB22591	Applications	Species
Meigen Yu, Hui Ye, Ruth B. De-Paula, Carl Grant Mangleburg, Timothy Wu, Tom V. Lee et al. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity PLOS Genetics 5/18/2023 [PMID: 37200393]
Caitlin E. O’Brien, Susan H. Younger, Lily Yeh Jan, Yuh Nung Jan The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling Journal of Cell Biology 1/2/2023 [PMID: 36239632]
L Wang, G Lin, Z Zuo, Y Li, SK Byeon, A Pandey, HJ Bellen Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia Oncogene, 2022-07-13;8(28):eabn3326. 2022-07-13 [PMID: 35857503] (IHC, Drosophila melanogaster)	IHC	Drosophila melanogaster
X Tao, Y Zhu, Z Diaz-Perez, SH Yu, JR Foley, TM Stewart, RA Casero, R Steet, RG Zhai Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells JCI Insight, 2022-07-08;7(13):. 2022-07-08 [PMID: 35801587] (IHC, Western Blot, Drosophila melanogaster)	IHC, Western Blot	Drosophila melanogaster
JR Florian, SJ DeMatte, DM Sweeder, RW Ordway, F Kawasaki Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis PLoS ONE, 2021-05-06;16(5):e0251184. 5/6/2021 [PMID: 33956855]
Torsten W.B. Götz, Dmytro Puchkov, Veronika Lysiuk, Janine Lützkendorf, Alexander G. Nikonenko, Christine Quentin et al. Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi Journal of Cell Biology 5/3/2021 [PMID: 33822845]
CG Mangleburg, T Wu, HK Yalamanchi, C Guo, YC Hsieh, DM Duong, EB Dammer, PL De Jager, NT Seyfried, Z Liu, JM Shulman Integrated analysis of the aging brain transcriptome and proteome in tauopathy Mol Neurodegener, 2020-09-29;15(1):56. 2020-09-29 [PMID: 32993812] (Western Blot, Drosophila)	Western Blot	Drosophila
Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li et al. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain eLife 4/14/2020 [PMID: 32286230]
AA Mondragon, A Yalonetska, AJ Ortega, Y Zhang, O Naranjo, J Elguero, WS Chung, K McCall Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death Cell Rep, 2019-04-02;27(1):11-19.e3. 2019-04-02 [PMID: 30943394] (IHC)	IHC
M ?entürk, G Lin, Z Zuo, D Mao, E Watson, AG Mikos, HJ Bellen Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification Nat. Cell Biol., 2019-02-25;21(3):384-396. 2019-02-25 [PMID: 30804504] (Western Blot, Insect)	Western Blot	Insect
D Mao, G Lin, B Tepe, Z Zuo, KL Tan, M Senturk, S Zhang, BR Arenkiel, M Sardiello, HJ Bellen VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway Autophagy, 2019-02-20;0(0):. 2019-02-20 [PMID: 30741620] (IHC, Human)	IHC	Human
C Li, JM Brazill, S Liu, C Bello, Y Zhu, M Morimoto, L Cascio, R Pauly, Z Diaz-Perez, MCV Malicdan, H Wang, L Boccuto, CE Schwartz, WA Gahl, CF Boerkoel, RG Zhai Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome Nat Commun, 2017-11-02;8(1):1257. 2017-11-02 [PMID: 29097652] (Western Blot, Drosophila)	Western Blot	Drosophila
Medina Hasanagic, Eline van Meel, Shan Luan, Rajeev Aurora, Stuart Kornfeld, Joel C. Eissenberg The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster Biology Open 10/15/2015 [PMID: 26405051]
Luan S, Ilvarsonn A, Eissenberg J The unique GGA clathrin adaptor of Drosophila melanogaster is not essential. PLoS ONE, 2012-09-20;7(9):e45163. 2012-09-20 [PMID: 23028818] (Western Blot, Drosophila)	Western Blot	Drosophila
Johnson GD, Jiang W Characterization of cathepsin L secreted by Sf21 insect cells. Arch. Biochem. Biophys., 2005-10-21;444(1):7-14. 2005-10-21 [PMID: 16274658] (Immunoprecipitation, Western Blot, Insect)	Immunoprecipitation, Western Blot	Insect
Show All 15 Publications. Collapse Publications.

Array MAB22591

• Cathepsin L Antibodies
• Cathepsin L ELISA Kits
• Cathepsin L Lysates
• Cathepsin L Protein
• Cathepsin L ELISA
• Cathepsin L Proteins and Enzymes