Calpain S1 Antibody (3C4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 5 of 5.

Publications using H00000826-M01	Applications	Species
Gao Y, Hall C, MacLeod J, Greer PA et al. Genetic Models of Calpain Deficiency and Ectopic Expression. Methods Mol Biol. 2019-05-01 [PMID: 30617810]
Knuppel L, Heinzelmann K, Lindner M et al. FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis. Respir Res 2018-04-19 [PMID: 29673351]
Iguchi-Hashimoto M, Usui T, Yoshifuji H et al. Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-kB and Increased STAT5 Signals. PLoS One. 2011-10-27 [PMID: 22046434]
Tabata C, Tabata R, Nakano T. The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. Clin Exp Immunol162(3):560-7. doi: 10.1111/j.1365-2249.2010.04257.x. 2010-12-01 [PMID: 20846163]
Barker T, Leonard SW, Hansen J et al. Vitamin E and C supplementation does not ameliorate muscle dysfunction after anterior cruciate ligament surgery. Free Radic Biol Med. 2009-09-11 [PMID: 19751822]

Array H00000826-M01

• Calpain S1 Antibodies
• Calpain S1 ELISA Kits
• Calpain S1 Lysate
• Calpain S1 Proteins