Cadherin-11 Antibody (667039) [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Cadherin-11, also known as OB-Cadherin, is a 120 kDa member of the classical Cadherin family of calcium-dependent homophilic adhesion proteins. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity (1). Cadherin-11 is expressed in embryonic mesodermal tissues and contributes to the morphogenesis of the nervous and skeletal systems (2-4). It is expressed on osteoblasts in the adult where it promotes the differentiation of both osteoblasts and chondrocytes (5). Cadherin-11 is up‑regulated on breast cancer and prostate cancer cells which preferentially metastasize to bone (6, 7). It facilitates this metastasis via homophilic adhesion to bone marrow stroma and osteoblast-expressed Cadherin-11 (6‑8). In the synovium, Cadherin‑11 supports adhesion between synoviocytes but promotes cell invasion in synovitis and rheumatoid arthritis (9, 10). Its up‑regulation in the vasculature following injury contributes to intimal hyperplasia by inducing smooth muscle cell migration and proliferation (11). In the nervous system, Cadherin-11 interacts with FGF R1 to promote neurite extension from spinal cord explants (12). Mature human Cadherin‑11 consists of a 564 amino acid (aa) extracellular domain (ECD) with five tandem Cadherin repeats, a 23 aa transmembrane segment, and a 156 aa cytoplasmic domain (13, 14). Within the ECD, human Cadherin-11 shares 97% and 98% aa sequence identity with mouse and rat Cadherin‑11, respectively. An 80 kDa portion of the Cadherin‑11 ECD can be shed by proteolytic cleavage, and this fragment competes with the full length molecule for cell adhesion (3, 15). Alternate splicing of human Cadherin-11 generates an 85 kDa isoform with substituted transmembrane and cytoplasmic regions (14, 15).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: Flow Cytometry, Fluorescense Microscopy, ICC, IHC-P, Immunocytochemistry.

Showing Publications 1 - 9 of 9.

Publications using FAB17901G	Applications	Species
M Sun, Z Chen, Y Song, B Zhang, J Yang, H Tan PLXND1-mediated calcium dyshomeostasis impairs endocardial endothelial autophagy in atrial fibrillation Frontiers in Physiology, 2022-08-09;13(0):960480. 2022-08-09 [PMID: 36017337] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
RY Ebright, MA Zachariah, DS Micalizzi, BS Wittner, KL Niederhoff, LT Nieman, B Chirn, DF Wiley, B Wesley, B Shaw, E Nieblas-Be, L Atlas, A Szabolcs, AJ Iafrate, M Toner, DT Ting, PK Brastianos, DA Haber, S Maheswaran HIF1A signaling selectively supports proliferation of breast cancer in the brain Nature Communications, 2020-12-09;11(1):6311. 2020-12-09 [PMID: 33298946] (ICC, Human)	ICC	Human
S Mount, P Kanda, S Parent, S Khan, C Michie, L Davila, V Chan, RA Davies, H Haddad, D Courtman, DJ Stewart, DR Davis Physiologic expansion of human heart-derived cells enhances therapeutic repair of injured myocardium Stem Cell Res Ther, 2019-11-04;10(1):316. 2019-11-04 [PMID: 31685023] (Flow Cytometry, Human)	Flow Cytometry	Human
M Pedroza, S To, J Smith, SK Agarwal Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride PLoS ONE, 2019-07-03;14(7):e0218971. 2019-07-03 [PMID: 31269038] (Fluorescense Microscopy, IHC-P, Mouse, Human)	Fluorescense Microscopy, IHC-P	Mouse, Human
Nicola Aceto, Aditya Bardia, Ben S. Wittner, Maria C. Donaldson, Ryan O'Keefe, Amanda Engstrom et al. AR Expression in Breast Cancer CTCs Associates with Bone Metastases Molecular Cancer Research 4/1/2018 [PMID: 29453314]
M Pedroza, RL Welschhans, SK Agarwal Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model PLoS ONE, 2017-11-07;12(11):e0187109. 2017-11-07 [PMID: 29112946] (IHC-P, Mouse)	IHC-P	Mouse
MH Park, E Reátegui, W Li, SN Tessier, KH Wong, AE Jensen, V Thapar, D Ting, M Toner, SL Stott, PT Hammond Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding and Ligand Exchange in a Microfluidic Chip J. Am. Chem. Soc., 2017-02-09;139(7):2741-2749. 2017-02-09 [PMID: 28133963] (Immunocytochemistry, Human)	Immunocytochemistry	Human
Josephine Shaw Bagnall, Sangwon Byun, David T. Miyamoto, Joon Ho Kang, Shyamala Maheswaran, Shannon L. Stott et al. Deformability-based cell selection with downstream immunofluorescence analysis Integrative Biology 5/16/2016 [PMID: 26999591]
Josephine Shaw Bagnall, Sangwon Byun, Shahinoor Begum, David T. Miyamoto, Vivian C. Hecht, Shyamala Maheswaran et al. Deformability of Tumor Cells versus Blood Cells Scientific Reports 12/18/2015 [PMID: 26679988]

Array FAB17901G

• Cadherin-11 Antibodies
• Cadherin-11 Lysate
• Cadherin-11 Protein
• Cadherin-11 ELISA
• Cadherin-11 Proteins and Enzymes