BNIP3 Antibody (670621)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Bcl-2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), also known as 19 kDa interacting protein 3 (NIP3), is a proapoptotic member of Bcl-2 protein family. BNIP3 is a 194 amino acid, 21.5 kDa (predicted) protein that contains a single Bcl-2 homology 3 (BH3) domain and a C-terminal transmembrane domain required for mitochondrial localization, homodimerization, and regulation of its proapoptotic function. BNIP3 was identified as one of several proteins that interact with discrete domains of Bcl-2 and the E1B 19 kDa protein. Under conditions of prolonged oxygen deprivation, the hypoxia-induced protein HIF1-alpha activates expression of BNIP3, which in turn, promotes apoptosis under these conditions. The mechanism of BNIP3-mediated apoptosis is independent of caspase activation and cytochrome c release and is characterized by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation. Human BNIP3 shares 90% amino acid identity with mouse and rat BNIP3. Human BNIP3 shares 56% amino acid sequence identity with human BNIP3L.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 3 of 3.

Publications using MAB4147	Applications	Species
M Vanneste, Q Huang, M Li, D Moose, L Zhao, MA Stamnes, M Schultz, M Wu, MD Henry High content screening identifies monensin as an EMT-selective cytotoxic compound Sci Rep, 2019-02-04;9(1):1200. 2019-02-04 [PMID: 30718715] (Western Blot, Human)	Western Blot	Human
John Hays Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res., 2016-11-02;0(0):. 2016-11-02 [PMID: 27807188] (Western Blot, Human)	Western Blot	Human
Notte A, Ninane N, Arnould T, Michiels C. Hypoxia counteracts taxol-induced apoptosis in MDA-MB-231 breast cancer cells: role of autophagy and JNK activation. Cell Death Dis. 1/1/2013 [PMID: 23681233]

Array MAB4147

• BNIP3 Antibodies
• BNIP3 Lysate
• BNIP3 Proteins