Bag-1 Antibody

The BAG (Bcl-2-associated anthanogene) proteins are a family of chaperone regulators that modulate several diverse processes including proliferation, survival, stress responses, tumorigenesis, neuronal differentiation, growth arrest and apoptosis (reviewed Takayama and Reed, 2001; Doong et al, 2002, and Doukhanina et al. 2006). BAG proteins have been characterized as co-chaperones and interact with the chaperone heat shock proteins 70, both constitutive Hsc70 and inducible Hsp70. BAG proteins bind through their BAG domain to the ATPase domain of Hsc70/Hsp70 and can modulate either positively or negatively the functions of the Hsc70/Hsp70 chaperone proteins. The BAG domain has been shown to contribute to the anti-apoptotic activity of BAG- family proteins. The anti-apoptotic activities of BAG-family proteins may be dependent on their interactions with Hsc70/Asp70 and/or binding to Bcl-2. In addition to the conserved BAG domain, BAG-family proteins also contain additional domains which enable them to interact with specific target proteins or to target them to specific locations within cells. The BAG family contains at least six family members, including BAG-1 and its various isoforms [including BAG-1S, BAG-1M (Rap46/Hap46), and BAG-1L, BAG-2, BAG-3 (CAIR-1; Bis,), BAG-4 (SODD), BAG-5 and BAG-6 (Scythe, BAT3). The following amino acids lengths and molecular weights (kDa) have been described for human BAG proteins (reviewed in Takayama et al, 2001 and Doong et al, 2002): BAG-1 (230 amino acid, 34 kDa), BAG-1S (219 amino acid, 29 kDa), BAG-1M (274 amino acid, 46 kDa), BAG-1L (345 amino acid, 52 kDa), BAG-2 [212 amino acid; 24 kDa (Arndt et al. 2005)], BAG-3 (575 amino acid, 74 kDa), BAG-4 (456 amino acid; 60 kDa), BAG-5 ([442 amino acid; 51 kDa (Kalia et al. 2004)], and BAG-6 (1129 amino acid; 150 kDa). Recognizes both BAG-1 and BAG-1 isoforms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NB100-56086

• Bag-1 Antibodies
• Bag-1 Lysate
• Bag-1 Proteins