Amylin Antibody (R10/99)

Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 7 of 7.

Publications using NB600-713	Applications	Species
Burillo J, Fernández-Rhodes M, Piquero M, et al. Human amylin aggregates release within exosomes as a protective mechanism in pancreatic beta cells: Pancreatic beta -hippocampal cell communication Biochimica et biophysica acta. Molecular cell research 2021-01-27 [PMID: 33515645]
Zhao H, Guan J, Lee HM et al. Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition. Pancreas. 2010-08-01 [PMID: 20467341]
Gurlo T, Ryazantsev S, Huang CJ et al. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010-02-01 [PMID: 20042670]
Zhao HL, Sui Y, Guan J et al. Amyloid oligomers in diabetic and nondiabetic human pancreas. Transl Res. 2009-01-01 [PMID: 19100955]
Nakamura S, Okabayashi S, Ageyama N et al. Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey. Vet Pathol. 2008-01-01 [PMID: 18192580]
Gong W, Liu ZH, Zeng CH et al. Amylin deposition in the kidney of patients with diabetic nephropathy. Kidney Int. 2007-07-01 [PMID: 17495860]
Bhattacharya S, Latha JN, Kumresan R et al. Cloning and expression of human islet amyloid polypeptide in cultured cells. Biochem Biophys Res Commun. 2007-05-01 [PMID: 17374526]

Array NB600-713

• Amylin Antibodies
• Amylin ELISA Kits
• Amylin Lysate
• Amylin Protein