SH2D1A Antibody (1C9)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 9 of 9.

Publications using H00004068-M01	Applications	Species
Houghton BC, Panchal N, Haas SA et al. Genome Editing With TALEN, CRISPR-Cas9 and CRISPR-Cas12a in Combination With AAV6 Homology Donor Restores T Cell Function for XLP Frontiers in Genome Editing 2022-05-23 [PMID: 35677600]
Khanolkar A, Wilks J, Liu G et al. Detailed Phenotypic and Functional Characterization of a Rare, Antibody-Dependent SLAM-Associated Protein Expression Pattern. Immunohorizons. 2020-04-10 [PMID: 32276922]
Panchal N, Houghton B, Diez B et al. Transfer of gene corrected T cells corrects humoral and cytotoxic defects in X-linked lymphoproliferative disease (XLP1). J Allergy Clin Immunol 2018-04-26 [PMID: 29705247]
Cetica V, Sieni E, Pende D et al. Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry. Journal of Allergy and Clinical Immunology. 2015-09-01 [PMID: 26342526]
Meazza R, Tuberosa C, Cetica V et al. Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis. J Allergy Clin Immunol. 2014-06-27 [PMID: 24985396]
Menard L, Cantaert T, Chamberlain N et al. Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J Allergy Clin Immunol. 2013-12-24 [PMID: 24373350]
Palendira U, Low C, Bell AI et al. Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus. J Exp Med. 2012-04-09 [PMID: 22493517]
Palendira U, Low C, Chan A et al. Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP. PLoS Biol. 2011-11-01 [PMID: 22069374]
Ma CS, Suryani S, Avery DT et al. Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol. 2009-09-01 [PMID: 19721453]

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Amairelys Barroeta	Flow	Human	12/10/2020	View Summary Application Flow Cytometry Sample Tested T cells Species Human Lot K2241-1C9 Comments Comments Intracellular Staining

Array H00004068-M01

• SH2D1A Antibodies
• SH2D1A Antibody Pair
• SH2D1A Lysate
• SH2D1A Protein