alpha-L-Iduronidase/IDUA Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

alpha -L-Iduronidase encoded by the IDUA gene is an important enzyme required for the lysosomal degradation of glycosaminoglycans (GAGs). It hydrolyzes the non‑reducing terminal alpha -L-iduronic acid residues in GAGs including dermatan sulfate and heparan sulfate. Mutations in IDUA that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I) (1). MPS I causes progressive cellular, tissue and organ damage, and several clinical studies using enzyme replacement therapy have shown promising benefits (2).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Transgenic Mouse.

We have publications tested in 4 applications: ELISA Capture, ICC, IHC-P, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF4119	Applications	Species
A Luthra, RA Spanjaard, S Cheema, N Veith, L Kober, Y Wang, T Jing, Y Zhao, F Hoeksema, C Yallop, M Havenga, WAM Bakker STEP� vectors for rapid generation of stable transfected CHO cell pools and clones with high expression levels and product quality homogeneity of difficult-to-express proteins Protein Expression and Purification, 2021-05-25;0(0):105920. 2021-05-25 [PMID: 34044134] (ELISA Capture, Human)	ELISA Capture	Human
L Ou, RC DeKelver, M Rohde, S Tom, R Radeke, SJ St Martin, Y Santiago, S Sproul, MJ Przybilla, BL Koniar, KM Podetz-Ped, K Laoharawee, RD Cooksley, KE Meyer, MC Holmes, RS McIvor, T Wechsler, CB Whitley ZFN-Mediated In�Vivo Genome Editing Corrects Murine Hurler Syndrome Mol. Ther., 2018-11-01;0(0):. 2018-11-01 [PMID: 30528089] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
J Hordeaux, C Hinderer, T Goode, N Katz, EL Buza, P Bell, R Calcedo, LK Richman, JM Wilson Toxicology Study of Intra-Cisterna Magna Adeno-Associated Virus 9 Expressing Human Alpha-L-Iduronidase in Rhesus Macaques Mol Ther Methods Clin Dev, 2018-07-14;10(0):79-88. 2018-07-14 [PMID: 30073179] (IHC-P, Human)	IHC-P	Human
Hidehito Kondo Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms Hum. Mol. Genet, 2017-01-01;0(0):. 2017-01-01 [PMID: 28013294] (ICC, Human)	ICC	Human

Array AF4119

• alpha-L-Iduronidase/IDUA Antibodies
• alpha-L-Iduronidase/IDUA ELISA Kits
• alpha-L-Iduronidase/IDUA Proteins
• alpha-L-Iduronidase/IDUA Proteins and Enzymes