ALK-7/Activin Receptor Type 1C Antibody (810506) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin receptor-like kinase 7 (ALK-7), also known as Activin R1C (gene name ACVR1C), is a glycosylated 58 kDa type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. It associates with type II receptors to form a signaling complex that responds to the ligands Activin AB, and Activin B, GDF3, and Nodal. ALK-7 plays a role in regulating energy balance by inhibiting insulin secretion and inducing pancreatic beta cell apoptosis. It is expressed in adipose tissue but downregulated in obesity. ALK-7 is also expressed in pituitary gonadotropic cells and in pre-eclamptic placenta. It induces the apoptosis of trophoblasts as well as ovarian granulosa and epithelial cells. Within the extracellular domain, human ALK-7 shares 95% and 91% amino acid (aa) sequence identity with mouse and rat ALK-7, respectively. Alternate splicing of human ALK-7 generates additional isoforms with either a 50 aa N-terminal truncation or with deletions of 79 aa or 157 aa that encompass the transmembrane segment.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Flow Cytometry, Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB77491	Applications	Species
T Khan, AM Seddon, AG Dalgleish, S Khelwatty, N Ioannou, S Mudan, H Modjtahedi Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancer Oncol Rep, 2020-10-22;0(0):. 2020-10-22 [PMID: 33125153] (Flow Cytometry, Human)	Flow Cytometry	Human
Helmout Modjtahedi Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs Int. J. Oncol., 2016-09-05;49(5):1825-1838. 2016-09-05 [PMID: 27599579] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human

Array MAB77491

• ALK-7/Activin Receptor Type 1C Antibodies
• ALK-7/Activin Receptor Type 1C Lysates
• ALK-7/Activin Receptor Type 1C Proteins
• ALK-7/Activin Receptor Type 1C Proteins and Enzyme