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ALK-7/Activin Receptor Type 1C Antibody (810506) [Allophycocyanin]

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PC-3 human prostate cancer cell line was stained with Mouse Anti-Human ALK-7 APC-conjugated Monoclonal Antibody (Catalog # FAB77491A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
PC-3 human prostate cancer cell line was stained with Mouse Anti-Human ALK-7 APC-conjugated Monoclonal Antibody (Catalog # FAB77491A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
810506
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB77491U-100UG
Alexa Fluor 405
FAB77491V-100UG
Alexa Fluor 488
FAB77491G-100UG
Alexa Fluor 532
FAB77491X
Alexa Fluor 594
FAB77491T-100UG
Alexa Fluor 647
FAB77491R-100UG
Alexa Fluor 700
FAB77491N-100UG
Alexa Fluor 750
FAB77491S-100UG
Allophycocyanin/Cy7
FAB77491APCCY7
Biotin
FAB77491B
CoraFluor 1
FAB77491CL1
DyLight 350
FAB77491D
DyLight 405
FAB77491E
DyLight 488
FAB77491K
DyLight 550
FAB77491L
DyLight 594
FAB77491M
DyLight 650
FAB77491W
DyLight 680
FAB77491Y
DyLight 755
FAB77491Z
FITC
FAB77491F
HRP
FAB77491H
Janelia Fluor 525
FAB77491JF525
Janelia Fluor 549
FAB77491I
Janelia Fluor 585
FAB77491JF585
Janelia Fluor 635
FAB77491JF635
Janelia Fluor 646
FAB77491J
Janelia Fluor 669
FAB77491JF669
PE
FAB77491P
PE/Atto594
FAB77491PEATT594
PE/Cy5.5
FAB77491PECY55
PE/Cy7
FAB77491PECY7
PerCP
FAB77491C
Unconjugated
MAB77491
mFluor Violet 450 SE
FAB77491MFV450
mFluor Violet 500 SE
FAB77491MFV500
mFluor Violet 610 SE
FAB77491MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB77491
Carrier Free
MAB77491
Carrier Free
MAB77491-SP
Carrier Free
FAB77491T-100UG
Carrier Free
FAB77491S-100UG
Carrier Free
FAB77491R-100UG
Carrier Free
FAB77491N-100UG
Carrier Free
FAB77491G-100UG
Carrier Free
FAB77491V-100UG
Carrier Free
FAB77491U-100UG
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ALK-7/Activin Receptor Type 1C Antibody (810506) [Allophycocyanin] Summary

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human ALK‑7
Leu26-Glu113
Accession # Q8NER5
Specificity
Detects human ALK‑7 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant rat ALK-7 is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
ACVR1C
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells
Publications
Read Publications using
FAB77491A in the following applications:

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ALK-7/Activin Receptor Type 1C Antibody (810506) [Allophycocyanin]

  • activin A receptor, type IC
  • Activin receptor type IC
  • activin receptor type-1C
  • Activin receptor-like kinase 7
  • Activin RIC
  • ACTR-IC
  • ACVR1C
  • ACVRLK7
  • ALK7
  • ALK-7
  • ALK7ALK-7
  • EC 2.7.11
  • EC 2.7.11.30

Background

Activin Receptor-like Kinase 7 (ALK-7), also known as Activin R1C (gene name ACVR1C), is a glycosylated 58 kDa type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. It associates with type II receptors to form a signaling complex that responds to the ligands Activin AB, and Activin B, GDF3, and Nodal. ALK-7 plays a role in regulating energy balance by inhibiting insulin secretion and inducing pancreatic beta cell apoptosis. It is expressed in adipose tissue but downregulated in obesity. ALK-7 is also expressed in pituitary gonadotropic cells and in pre-eclamptic placenta. It induces the apoptosis of trophoblasts as well as ovarian granulosa and epithelial cells. Within the extracellular domain, human ALK-7 shares 95% and 91% amino acid (aa) sequence identity with mouse and rat ALK-7, respectively. Alternate splicing of human ALK-7 generates additional isoforms with either a 50 aa N-terminal truncation or with deletions of 79 aa or 157 aa that encompass the transmembrane segment.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for ALK-7/Activin Receptor Type 1C Antibody (FAB77491A)(2)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.


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Flow Cytometry
(2)
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(2)
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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ACVR1C
Uniprot