ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type Ireceptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interactdirectly with DNA or in complex with other transcription factors (Bondestam et al., 2001 (PubMed 12063393)).(suppliedby OMIM)