AGER Antibody (175410) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Advanced glycation endproducts (AGE) are adducts formed by the non-enzymatic glycation or oxidation of macromolecules (1). AGE forms during aging and its formation is accelerated under pathophysiologic states such as diabetes, Alzheimer’s disease, renal failure and immune/inflammatory disorders. Receptor for Advanced Glycation Endoproducts (RAGE), named for its ability to bind AGE, is a multiligand receptor belonging the immunoglobulin (Ig) superfamily. Besides AGE, RAGE binds amyloid beta -peptide, S100/calgranulin family proteins, high mobility group B1 (HMGB1, also know as amphoterin) and leukocyte integrins (1, 2). The mouse RAGE gene encodes a 403 amino acid (aa) residue type I transmembrane glycoprotein with a 22 aa signal peptide, a 319 aa extracellular domain containing a Ig-like V‑type domain and two Ig-like Ce-type domains, a 21 aa transmembrane domain and a 41 aa cytoplasmic domain (3). The V‑type domain and the cytoplasmic domain are important for ligand binding and for intracellular signaling, respectively. Two alternative splice variants, lacking the V‑type domain or the cytoplasmic tail, are known (1, 4). RAGE is highly expressed in the embryonic central nervous system (5). In adult tissues, RAGE is expressed at low levels in multiple tissues including endothelial and smooth muscle cells, mononuclear phagocytes, pericytes, microglia, neurons, cardiac myocytes and hepatocytes (6). The expression of RAGE is upregulated upon ligand interaction. Depending on the cellular context and interacting ligand, RAGE activation can trigger differential signaling pathways that affect divergent pathways of gene expression (1, 7). RAGE activation modulates varied essential cellular responses (including inflammation, immunity, proliferation, cellular adhesion and migration) that contribute to cellular dysfunction associated with chronic diseases such as diabetes, cancer, amyloidoses, and immune or inflammatory disorders (1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Mouse, Rat, Hamster.

We have publications tested in 9 applications: Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Immunohistochemistry, Immunoprecipitation, Neutralization, Western Blot.

Showing Publications 1 - 10 of 56. Show All 56 Publications. Collapse Publications.

Publications using MAB1179	Applications	Species
Lv, Z;Liu, Z;Liu, K;Lin, X;Pu, W;Li, Y;Zhao, H;Xi, Y;Sui, P;Vaughan, AE;Gillich, A;Zhou, B; Alveolar regeneration by airway secretory-cell-derived p63+ progenitors Cell stem cell 2024-08-30 [PMID: 39232560] (Immunohistochemistry, Mouse)	Immunohistochemistry	Mouse
Clarke, DM;Curtis, KL;Wendt, RA;Stapley, BM;Clark, ET;Beckett, N;Campbell, KM;Arroyo, JA;Reynolds, PR; Decreased Expression of Pulmonary Homeobox NKX2.1 and Surfactant Protein C in Developing Lungs That Over-Express Receptors for Advanced Glycation End-Products (RAGE) Journal of developmental biology 2023-07-15 [PMID: 37489334] (IHC, Mouse)	IHC	Mouse
Kaiser, AM;Gatto, A;Hanson, KJ;Zhao, RL;Raj, N;Ozawa, MG;Seoane, JA;Bieging-Rolett, KT;Wang, M;Li, I;Trope, WL;Liou, DZ;Shrager, JB;Plevritis, SK;Newman, AM;Van Rechem, C;Attardi, LD; p53 governs an AT1 differentiation programme in lung cancer suppression Nature 2023-07-01 [PMID: 37468633] (IHC, Mouse)	IHC	Mouse
Juul NH, Yoon JK, Martinez MC et al. KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming Nature 7/1/2023 [PMID: 37468622]
Warren, R;Lyu, H;Klinkhammer, K;De Langhe, SP; Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis eLife 2023-05-11 [PMID: 37166104] (IHC, Mouse)	IHC	Mouse
Cardenas-Diaz FL, Liberti DC, Leach JP et al. Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1 Cell reports 4/27/2023 [PMID: 37119134]
Q Li, Y Qiao, F Wang, J Zhao, L Wu, H Ge, S Xu Prenatal triclosan exposure impairs mammalian lung branching morphogenesis through activating Bmp4 signaling Ecotoxicology and environmental safety, 2023-04-12;256(0):114896. 2023-04-12 [PMID: 37054474] (IHC, Mouse)	IHC	Mouse
Han Z, Andr� M, Madhavan BK et al. The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress Nucleic acids research 3/21/2023 [PMID: 36807739]
Han Z, Andr� M, Madhavan BK et al. The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress Nucleic acids research 2023-03-21 [PMID: 36807739]
Larissa Allgäuer, Jan-Harry Cabungcal, Catherine Yzydorczyk, Kim Quang Do, Daniella Dwir Low protein-induced intrauterine growth restriction as a risk factor for schizophrenia phenotype in a rat model: assessing the role of oxidative stress and neuroinflammation interaction Translational Psychiatry 2/1/2023 [PMID: 36720849]
Aaron I. Weiner, Gan Zhao, Hanna M. Zayas, Nicolas P. Holcomb, Stephanie Adams-Tzivelekidis, Joanna Wong et al. delta Np63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury Cell Reports 12/13/2022 [PMID: 36516758]
Kim SH, Kim J, Jang JY et al. Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits Frontiers in Immunology 11/15/2022 [PMID: 36457995]
DG Brownfield, AD de Arce, E Ghelfi, A Gillich, TJ Desai, MA Krasnow Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling Nature Communications, 2022-11-21;13(1):7137. 2022-11-21 [PMID: 36414616] (IHC, Mouse)	IHC	Mouse
H Jeong, YW Lee, IH Park, H Noh, SH Kim, J Kim, D Jeon, HJ Jang, J Oh, D On, C Uhm, K Cho, H Oh, S Yoon, JS Seo, JJ Kim, SH Seok, YJ Lee, SM Hong, SH An, SY Kim, YB Kim, JY Hwang, HJ Lee, HB Kim, DG Jeong, D Song, M Song, MS Park, KS Choi, JW Park, JY Seo, JW Yun, JS Shin, HY Lee, KT Nam, JK Seong Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mice and Syrian golden hamster models Disease Models & Mechanisms, 2022-11-11;0(0):. 2022-11-11 [PMID: 36222118] (IHC, Hamster, Mouse)	IHC	Hamster, Mouse
Arvind Konkimalla, Satoshi Konishi, Yoshihiko Kobayashi, Preetish Kadur Lakshminarasimha Murthy, Lauren Macadlo, Ananya Mukherjee et al. Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration iScience 10/21/2022 [PMID: 36185377]
Ariel Pribluda, Anneleen Daemen, Anthony Nelson Lima, Xi Wang, Marc Hafner, Chungkee Poon et al. EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation eLife 8/19/2022 [PMID: 35983994]
S Chen, X Zhang, C Yang, S Wang, H Shen Essential role of IL-17 in acute exacerbation of pulmonary fibrosis induced by non-typeable Haemophilus influenzae Theranostics, 2022-07-04;12(11):5125-5137. 2022-07-04 [PMID: 35836804] (IHC, Mouse)	IHC	Mouse
Satoshi Konishi, Aleksandra Tata, Purushothama Rao Tata Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures STAR Protocols 6/17/2022 [PMID: 35712012]
YT Shue, AP Drainas, NY Li, SM Pearsall, D Morgan, N Sinnott-Ar, SQ Hipkins, GL Coles, JS Lim, AE Oro, KL Simpson, C Dive, J Sage A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs Nature Communications, 2022-05-16;13(1):2690. 2022-05-16 [PMID: 35577801] (IHC, Mouse)	IHC	Mouse
Jeon HY, Choi J, Kraaier L et al. Airway secretory cell fate conversion via YAP-mTORC1-dependent essential amino acid metabolism The EMBO journal 3/14/2022 [PMID: 35285539]
M Li, CY Ong, CJ Langouët-A, L Tan, A Verma, Y Yang, X Zhang, DK Shah, EP Schmidt, D Xu Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE Elife, 2022-02-09;11(0):. 2022-02-09 [PMID: 35137686] (Western Blot, Mouse)	Western Blot	Mouse
J Liu, S Zhu, L Zeng, J Li, DJ Klionsky, G Kroemer, J Jiang, D Tang, R Kang DCN released from ferroptotic cells ignites AGER-dependent immune responses Autophagy, 2021-12-29;0(0):1-14. 2021-12-29 [PMID: 34964698] (Immunoprecipitation, Neutralization, Western Blot, Mouse)	Immunoprecipitation, Neutralization, Western Blot	Mouse
K Gkatzis, P Panza, S Peruzzo, DY Stainier Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures Elife, 2021-09-29;10(0):. 2021-09-29 [PMID: 34586063] (IHC, Mouse)	IHC	Mouse
CH Lee, KW Kim, DH Lee, SM Lee, SY Kim Overexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss Bmc Neuroscience, 2021-05-21;22(1):38. 2021-05-21 [PMID: 34020590] (IHC, Western Blot, Rat)	IHC, Western Blot	Rat
DC Liberti, MM Kremp, WA Liberti, IJ Penkala, S Li, S Zhou, EE Morrisey Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury Cell Reports, 2021-05-11;35(6):109092. 2021-05-11 [PMID: 33979629] (IHC, Mouse)	IHC	Mouse
Qian Chen, Yuru Liu Isolation and culture of mouse alveolar type II cells to study type II to type I cell differentiation STAR Protocols 3/1/2021 [PMID: 33437966]
CH Lee, KW Kim, SM Lee, SY Kim Dose-Dependent Effects of Resveratrol on Cisplatin-Induced Hearing Loss International Journal of Molecular Sciences, 2020-12-24;22(1):. 2020-12-24 [PMID: 33374326] (Western Blot, Rat)	Western Blot	Rat
Gan Zhao, Aaron I. Weiner, Katherine M. Neupauer, Maria Fernanda de Mello Costa, Gargi Palashikar, Stephanie Adams-Tzivelekidis et al. Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2 Science Advances 2020-11-27 [PMID: 33239293]
Gan Zhao, Aaron I. Weiner, Katherine M. Neupauer, Maria Fernanda de Mello Costa, Gargi Palashikar, Stephanie Adams-Tzivelekidis et al. Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2 Science Advances 11/27/2020 [PMID: 33239293]
H Katsura, V Sontake, A Tata, Y Kobayashi, CE Edwards, BE Heaton, A Konkimalla, T Asakura, Y Mikami, EJ Fritch, PJ Lee, NS Heaton, RC Boucher, SH Randell, RS Baric, PR Tata Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction Cell Stem Cell, 2020-10-21;0(0):. 2020-10-21 [PMID: 33128895] (IHC, Mouse)	IHC	Mouse
M Cassandras, C Wang, J Kathiriya, T Tsukui, P Matatia, M Matthay, P Wolters, A Molofsky, D Sheppard, H Chapman, T Peng Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung Nat Cell Biol, 2020-10-12;0(0):. 2020-10-12 [PMID: 33046884] (IHC, Mouse)	IHC	Mouse
Kobayashi, Y, Tata, A Et al. Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. Nat Cell Biol 8/1/2020 [PMID: 32661339]
Q Chen, J Rehman, M Chan, P Fu, SM Dudek, V Natarajan, AB Malik, Y Liu Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair Cell Rep, 2020-06-30;31(13):107828. 2020-06-30 [PMID: 32610129] (IHC, Mouse)	IHC	Mouse
Lisandra Vila Ellis, Margo P. Cain, Vera Hutchison, Per Flodby, Edward D. Crandall, Zea Borok et al. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung Developmental Cell 3/1/2020 [PMID: 32059772]
JJ Kathiriya, AN Brumwell, JR Jackson, X Tang, HA Chapman Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration Cell Stem Cell, 2020-01-23;0(0):. 1/23/2020 [PMID: 31978363]
T Sun, Z Huang, H Zhang, C Posner, G Jia, TR Ramalingam, M Xu, HD Brightbill, JG Egen, A Dey, JR Arron TAZ is required for lung alveolar epithelial cell differentiation after injury JCI Insight, 2019-06-18;5(0):. 2019-06-18 [PMID: 31211697] (IHC, Mouse)	IHC	Mouse
H Katsura, Y Kobayashi, PR Tata, BLM Hogan IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration Stem Cell Reports, 2019-03-28;0(0):. 2019-03-28 [PMID: 30930244] (IHC-P, Mouse)	IHC-P	Mouse
Daniella Dwir, Basilio Giangreco, Lijing Xin, Liliane Tenenbaum, Jan-Harry Cabungcal, Pascal Steullet et al. MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients Molecular Psychiatry 11/1/2020 [PMID: 30911107]
Wenguang Yin, Hyun-Taek Kim, ShengPeng Wang, Felix Gunawan, Rui Li, Carmen Buettner et al. Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis European Respiratory Journal 3/1/2019 [PMID: 30578393]
Mei-I Chung, Brigid L. M. Hogan Ager-CreERT2: A New Genetic Tool for Studying Lung Alveolar Development, Homeostasis, and Repair American Journal of Respiratory Cell and Molecular Biology 12/1/2018 [PMID: 30011373]
K Kato, R Diéguez-Hu, DY Park, SP Hong, S Kato-Azuma, S Adams, M Stehling, B Trappmann, JL Wrana, GY Koh, RH Adams Pulmonary pericytes regulate lung morphogenesis Nat Commun, 2018-06-22;9(1):2448. 2018-06-22 [PMID: 29934496] (IHC-P, Mouse)	IHC-P	Mouse
HY Kim, X Wang, R Kang, D Tang, BA Boone, HJ Zeh, MT Lotze, WB Edwards RAGE-specific single chain Fv for PET imaging of pancreatic cancer PLoS ONE, 2018-03-12;13(3):e0192821. 2018-03-12 [PMID: 29529089] (Flow Cytometry, ICC, IHC, Mouse)	Flow Cytometry, ICC, IHC	Mouse
Monica Nagendran, Daniel P Riordan, Pehr B Harbury, Tushar J Desai Automated cell-type classification in intact tissues by single-cell molecular profiling eLife 1/10/2018 [PMID: 29319504]
Xianhua Li, Zhaoli Gao, Haiqing Gao, Baoying Li, Tao Peng, Bei Jiang et al. Nephrin loss is reduced by grape seed proanthocyanidins in the experimental diabetic nephropathy rat model Molecular Medicine Reports 12/1/2017 [PMID: 29152654]
H Matsumoto, N Matsumoto, J Shimazaki, J Nakagawa, Y Imamura, K Yamakawa, T Yamada, M Ikeda, H Hiraike, H Ogura, T Shimazu Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury Sci Rep, 2017-09-25;7(1):12255. 2017-09-25 [PMID: 28947744] (IHC, Rat)	IHC	Rat
AJ Lechner, IH Driver, J Lee, CM Conroy, A Nagle, RM Locksley, JR Rock Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy Cell Stem Cell, 2017-05-11;0(0):. 2017-05-11 [PMID: 28506464] (IHC, Mouse)	IHC	Mouse
Cindy M. Kanegai, Ying Xi, Matthew L. Donne, Jeffrey E. Gotts, Ian H. Driver, Gorica Amidzic et al. Persistent Pathology in Influenza-Infected Mouse Lungs American Journal of Respiratory Cell and Molecular Biology 10/1/2016 [PMID: 27689795]
J Yang, BJ Hernandez, D Martinez A, O Narvaez de, L Vila-Ellis, H Akiyama, SE Evans, EJ Ostrin, J Chen The development and plasticity of alveolar type 1 cells Development, 2015-11-19;143(1):54-65. 2015-11-19 [PMID: 26586225] (ICC, Mouse)	ICC	Mouse
Alanis , Denise M, Chang , Daniel R, Akiyama , Haruhiko, Krasnow , Mark A, Chen , Jichao Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nat Commun, 2014-05-29;5(0):3923. 2014-05-29 [PMID: 24879355] (IHC, Mouse)	IHC	Mouse
Desai , Tushar J, Brownfield , Douglas, Krasnow , Mark A Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature, 2014-02-05;507(7491):190-4. 2014-02-05 [PMID: 24499815] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Chang DR et al. Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A 11/1/2013 [PMID: 24058167]
Verena V. Metz, Elzbieta Kojro, Dorothea Rat, Rolf Postina Induction of RAGE Shedding by Activation of G Protein-Coupled Receptors PLoS ONE 7/30/2012 [PMID: 22860017]
Mizumoto S, Takahashi J, Sugahara K Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells. J. Biol. Chem., 2012-04-09;287(23):18985-94. 2012-04-09 [PMID: 22493510] (Neutralization, Mouse)	Neutralization	Mouse
Hallam KM, Li Q, Ananthakrishnan R, Kalea A, Zou YS, Vedantham S, Schmidt AM, Yan SF, Ramasamy R Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats. Aging Cell, 2010-08-15;9(5):776-84. 2010-08-15 [PMID: 20670350] (Western Blot, Rat)	Western Blot	Rat
Zhang H, Tasaka S, Shiraishi Y, Fukunaga K, Yamada W, Seki H, Ogawa Y, Miyamoto K, Nakano Y, Hasegawa N, Miyasho T, Maruyama I, Ishizaka A Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury. Am. J. Respir. Crit. Care Med., 2008-06-05;178(4):356-62. 2008-06-05 [PMID: 18535257] (Western Blot, Mouse)	Western Blot	Mouse
Parmley LA, Elkins ND, Fini MA, Liu YE, Repine JE, Wright RM Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury. Br. J. Pharmacol., 2007-09-10;152(6):915-29. 2007-09-10 [PMID: 17828290] (Western Blot, Rat)	Western Blot	Rat
Show All 56 Publications. Collapse Publications.

Array MAB1179

• AGER Antibodies
• AGER ELISA Kit
• AGER Lysate
• AGER Proteins
• AGER Proteins and Enzymes
• AGER ELISAs